Compositions for increasing nitrogen sources life span in plant growth mediums and methods of making

ABSTRACT

The present invention relates to compositions for increasing a nitrogen source life span in plant growth mediums as well as methods of making these compositions. The invention also relates to compositions and methods of reacting a nitrogen source with one or more nitrification inhibitors using standard equipment for producing nitrogen sourced particles.

The present invention claims priority under 35 USC 120 and is a continuation in part of U.S. application Ser. No. 16/154,640 filed Oct. 8, 2018, which is a continuation in part of U.S. application Ser. No. 15/985,656 filed May 21, 2018, which is a continuation in part of U.S. application Ser. No. 15/967,575 filed Apr. 30, 2018, which is a continuation in part of U.S. application Ser. No. 15/854,319 filed Dec. 26, 2017, which in turn claims priority under 35 USC 120 to U.S. application Ser. No. 15/641,264 filed Jul. 4, 2017, which in turn claims priority under 35 USC 119 to U.S. Provisional Application No. 62/358,116 filed Jul. 4, 2016, the entire contents of all of which are incorporated by reference in their entireties.

FIELD OF THE INVENTION

In embodiments, the present invention relates to liquid formulations comprising nitrification inhibitors chemically bound within a polymer/oligomer, dispersed within a Non-aqueous Organic Solvent Delivery System (abbreviated as NOSDS) for application to nitrogen sources. The method of making these polymeric and/or oligomeric nitrification inhibitors comprise a non-aqueous polar, aprotic organo liquid (abbreviated as NAPAOL) that is utilized as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols and wherein the process parameters are optimized for conserving the cyano group. A non-aqueous solvent delivery system (NOSDS) can be utilized to improve the physical properties of the liquid formulation wherein the NOSDS comprises the reaction medium, NAPAOL, aprotic solvents and protic solvents which are environmentally friendly, have flashpoints above 145° F. and are inherently rated safe for contact with humans and animals.

In embodiments, the present invention relates to liquid formulations containing hydrophobic, biodegradable polymers dispersed within a Non-aqueous Organic Solvent Delivery System (NOSDS) and is designed to coat fertilizer granules with a hydrophobic film utilizing simple application equipment such as mixers, blenders and tumblers. This film can impede the dissolution of fertilizer components by water improving fertilizer efficiency. The NOSDS can be aprotic solvents, protic solvents and mixtures of protic and aprotic solvents which are environmentally friendly, have flashpoints above 145° F., and are inherently rated safe for contact with humans and animals. The hydrophobic polymers are the reaction product of aldehyde(s) and nitrogen containing compounds.

BACKGROUND OF THE INVENTION

Fertilizer efficiency has become a major issue in the world. The major element of fertilizer is nitrogen (N). In one study, using data from over 800 experiments, it was estimated that only 51% of the N applied was recovered by cereals plant (Dobermann and Cassman 2005). In another study, it was reported that average N recovery in cereals in China was 30-35% (Fan 2004). Phosphorous is the second largest element in fertilizer compositions and its efficiency is even lower. It was estimated to be around 10-25% (Linsay 1979). Potassium is the third largest fertilizer composition and its efficiency is around 40% (Baligar V C 1986).

One of the main factors for the low efficiency of fertilizers is due to the excellent water solubility of many of its components. In practice, fertilizers are often just applied once at the beginning of the growing season. After the application, nutrients from fertilizers are dissolved in water and released to soil in amounts that are too much for plants to absorb. The unabsorbed nutrients can be leached to the environment, and find their way to surface water such as ponds, lakes and rivers or continue to leach into the sub-surface water table contaminating many of the rural community water supplies. Low efficiency of fertilizer not only increases the cost of fertilization, but also contributes significantly to environmental pollution. In the case of nitrogen based fertilizers, one of the major mechanisms for its poor efficiency is the impact of biologically driven processes on water solubilized sources of nitrogen. Urea is the main component of most nitrogen fertilizers. In the presence of soil moisture, natural or synthetic ureas are dissolved and are converted to ammonium ion by bacterial activity, making the nitrogen available for plant uptake. Ammonium can be further converted by bacteria in soil to nitrate through a process called nitrification. Nitrate is also available for plant uptake. Excess ammonia not absorbed by plants can leach into water which can be toxic to water creatures (US EPA822-R-13-001). Excess nitrates can also leach into water, causing the increasing of nitrate concentration in the ground water. Consumption of nitrate contaminated water by human can cause methemoglobinemia (blue baby syndrome) (Kross, Hallberg et al. 1993). Moreover, excessive nitrate can be converted into nitric oxide or nitrous oxide by certain types of bacteria in the soil, through a biological process called denitrification. Nitrous oxide is a potent greenhouse gas, whose potency on global warming is 300 times stronger than carbon dioxide (http://epa.gov/climatechange/ghgemissions/gases/n2o.html). In the case of phosphate fertilizer, phosphate fertilizer in the soil can be eroded into the river causing eutrophication, which can pose severe damage to the whole water body (Bennett E M 2001). Over usage of potassium fertilizer has been associated with deterioration of soil structure, The other problem associated with the over usage of potassium fertilizer is the disruption of the balance of nutrients in the soil such as Ca, Fe and Zn, that are in a plant available form (S 2012).

The goal of the worldwide agricultural industry is to increase the efficiency and decrease the environmental impact of fertilizer. One method is to apply the fertilizer in small doses but with more frequency. However, this approach will incur increased labor cost and is not economically practical, especially in developed countries, where the labor cost tends to be higher. A preferred method is to slow down the dissolution of water soluble fertilizer components and extend the period of time for release of nutrients in a plant available form. The current technological trend for slowing dissolution of fertilizer is focused on inventions that utilize various types of coatings which control water's access to the fertilizer's water soluble components. While many inventions claim the ability to coat any of the fertilizer components, the major commercialized coating-based products are centered around urea. To implement these inventions usually require separate process steps, heat and specialized application equipment for application of coatings to fertilizer. The choice of coating urea is based on (1) Urea is usually produced through a synthetic process making the additional steps of coating conveniently part of the overall urea preparation process, (2) urea is one of the more costly as well as one of the largest components in a fertilizer formulation and (3) urea bonds well with most organic coatings versus the inorganic nature of the other components of fertilizer. The core of the technology is that coating urea prills (granules) with a water-insoluble, semipermeable, or impermeable (with pores) material delays the release of N from the urea. Urea is highly soluble in water, but the solubility of coated urea is dependent on the coating material, its thickness, and the coverage and uniformity of the coating on the granule.

The first widely used urea coating technology is a sulfur coating in U.S. Pat. No. 3,342,577 (Blauin) which demonstrates a process of sulfur coating of urea particles to slow dissolution. It was developed in the late 1960's by the Tennessee Valley Authority (TVA) as an economical system for reducing the rate of dissolution when urea particles are applied to the soil as fertilizer. The release of nutrients from sulfur-coated fertilizers occurs by diffusion of water through imperfections in the sulfur coating and through coating breakdown. In this technology, urea is coated with molten sulfur. It is sometimes topped with a coating of wax to overcome the numerous granule surface imperfections as well as to mitigate damage to the coating through processing, packaging, storage and transport of the coated urea. Sulfur is water impermeable, but the cracks on the surface allow water to penetrate in the beginning. Overtime, sulfur is degraded by bacteria in the soil and urea is totally released (Christians 2004).

U.S. Pat. No. 4,551,166—(Behnke) discloses that the addition of dicyandiamide (DCD) can be carried out at several points in the urea-formaldehyde condensation reaction and utilize water as the reaction medium. DCD can either be added right at the beginning of the reaction, together with the urea and the formalin, or later during the reaction or at the end of the reaction, before or after cooling. Benke also discloses that the methylene bisurea analogue, methylene bisdicyandiamide, is not formed during the reaction.

Attempts to seal the sulfur coating have been described in U.S. Pat. No. 5,219,465 (Goertz), by utilizing a polymethylene poly(phenyl-isocyanate), a catalyst to promote polyurethane curing with polyester polyols to topcoat the sulfur on the surface. U.S. Pat. No. 5,599,374 (Detrick) relates to a process for producing sulfur-coated, slow release fertilizers having a uniform, durable polymeric coating over the sulfur-coating which improves impact and abrasion resistance properties. This polymer coating is formed by the direct in situ co-polymerization of diethylene glycol-triethanolamine polyol and a diisocyanate on the surface of the sulfur-coated urea granule.

U.S. Pat. No. 5,653,782 (Stern et. al.) describes a process by which fertilizer particles are preheated to a temperature in excess of the melting point of sulfur (115° C.), prior to being mixed with solid sulfur prills. The resulting fertilizer is comprised of fertilizer particles contained in a sulfur matrix.

U.S. Pat. No. 6,338,746 (Detrick et al.) describes a process of first coating a fertilizer with a polymer, then coating the polymer with sulfur and thereafter applying a polymer coating.

U.S. Pat. Application, 20100011825 (Ogle, et al.) teaches that multiple layers of coating for urea granules in which the urea is coated with a polymeric layer, an intermediate layer and sulfur layer outside.

While sulfur represents a low cost coating, it still required separate manufacturing steps, high temperatures (>120C) and is not attrition resistant during processing, packaging, storage and transporting without the addition of other additives.

Urethane polymer technologies have also been developed to coat urea fertilizer, which allows more precise rate of nitrogen release than sulfur coated urea. U.S. Pat. No. 3,264,089 (Hansen) and U.S. Pat. No. 3,475,154 (Kato) inventions involve preformed polymers in quick drying solvents. As these solvents are flashed off, their fumes create a low flash point hazard and can result in pinhole imperfections on the coated fertilizer. Isocyanate based polymers are utilized in a number of inventions which are based on a plurality of coatings in which a urethane polymer is formed on the surface of a fertilizer particle through separate coating of an isocyanate capable of crosslinking with compounds having multiple active hydrogens such as polyols or polyamine. Most inventions also include a final coating that is hard but not brittle to improve resistance to damage to the coatings during processing, packaging, storage and transport.

U.S. Pat. No. 5,538,531 (Hudson et al.) describes controlled release fertilizers and a method for their production. These controlled release fertilizers have a central mass of particulate fertilizer which contains at least one water soluble plant nutrient surrounded by a plurality of coatings. The inner coating comprises the reaction product of an aromatic, a polyol having from 2 to 6 hydroxyl units and at least one alkyl moiety containing from about 10 to 22 carbon atoms. An outer coating of a wax is also necessary.

U.S. Pat. No. 5,803,946 (Petcavich, et al.), teaches a urea particulate plant nutrient having on its surface an interpenetrating polymer network comprising a biuret, a urethane and tung oil.

U.S. Pat. No. 6,663,686 (Geiger et al.) teaches a process in which wax is used as a component of the polyurethane coating, not as a separate over-coat. The invention describes controlled release can be achieved with less coating materials and by a relatively simple procedure which in turn, permits the reduction of coat thickness. U.S. Pat. Application, 20040016276 (Wynnyk, et al.), utilizes an isocyanate and castor oil to build a urethane polymer for control release of the water soluble components of fertilizer and incorporates an inorganic and/or an organic particulate filler and, optionally, a wax in a one-step coating process. The addition of the particulate filler is touted as improving processing, handling, packaging and transport.

While many of these inventions have been shown to slow down the dissolution of urea, the processes, equipment and chemistries result in a coated urea that is very expensive when compared to uncoated urea and is mainly used for expensive crops and turf industry (LAL 1998). Many of these coatings also provide no nutritional value for plants.

Although the listed inventions claim to provide a coating to limit dissolution of other fertilizers components such as phosphorus, potassium and micronutrients, the cost of the application of such technologies has impaired their entry into the agricultural marketplace. While many of the coating technologies have strategies to overcome the attrition of coverage of the urea particle, the inorganic nature of the other fertilizer components causes difficulties in the adhesion of the coatings to the inorganic particles.

Natural based fertilizers such as manure are also not coated due to the cost of the coating operations, the quick loss of nitrogen value due to existing bacteria population and manure's amorphous physical nature.

Patent CN104803807 (Yuan) teaches us that urea, ammonium phosphate, potassium chloride, diammonium phosphate, monoammonium phosphate, potassium nitrate, potassium dihydrogen phosphate, magnesium humate, zinc humate, urea ion humate or nitro humic acid granules can be coated with dicyclopentadiene, glycerol ester copolymer, polyvinyl alc., and PMSM (p-methylstryrene-maleic anhydride copolymer).

Patent CN 104609983 (Li, et al.) teaches us that a hydrophobic film is formed on the surface of fertilizer granules by in situ reaction of polymethylene polyphenyl polyisocyanate and polyether polyol.

Patent CN 104446875 (Chen, et al.) teaches us that polycondensation reaction of citric acid, polyglycolic acid and potassium carbonate can form a slow releasing potassium fertilizer.

While all these technologies can slow down the dissolution of water soluble inorganic fertilizer components, the cost of the specialized equipment, chemistries and processing to produce the coated particle and the attrition of the coating coverage during processing, packaging, storage and transport has severely limited their utility for agriculture. Moreover, all these fertilizer must be made according to certain specifications in large volume and cannot be tailored to customer's specific needs. In light of the above, it is desirable to develop a slow release fertilizer coating technology which is environmental-friendly, low cost and can be applied with simple application equipment such as mixers blenders or tumblers. Moreover, this technology should be flexible enough to prepare small batches according to the customer's needs.

U.S. Pat. No. 9,440,890 (Gabrielson) teaches reaction products may be formed from the reaction of formaldehyde, DCD, urea, and an ammonia source in water which may be included in agricultural products, including fertilizer compositions and nitrification inhibitor systems. Gabrielson also states that fertilizer compositions that include the reaction product can be beneficial for reducing leaching of nitrification inhibitors applied to soil. However, the reactions are performed in an aqueous medium which limits their applications to systems or processes not negatively impacted by the presence of water. Gabrielson's invention also requires other formaldehyde reactive constituents such as urea and ammonia which have excellent water solubility to assist with the dissolution of dicyandiamide (DCD) since DCD has a limited solubility in water of approximately 32 grams/liter at 20° C. resulting in slower reactivity and low concentrations of DCD incorporated into the resulting polymers and/or oligomers. The resulting composition of the reaction product is reported to be a mixture of a triazonyl-formaldehyde-DCD adduct, a urea-formaldehyde-DCD adduct, and a DCD-formaldehyde-oligomer adduct.

In fact, the reported composition of the formaldehyde reaction product comprises only about 0.1 to 10 wt. % of a DCD-formaldehyde-oligomer adduct based upon the weight of the nitrification inhibitor system. Since the described invention requires water as a reaction medium and due to research reports that the presence of water is essential in driving the degradation of dicyandiamide to diaminomethylene ureas as shown in the following reaction,

(Ebisuno, Takimoto, Takahashi, Shiba, (1993))

the loss of the cyano-group would diminish the product's nitrification inhibition capabilities either directly or in a slow release mechanism that is dependent on microbial activity to break down the polymer/oligomer releasing dicyandiamide over time.

Gabrielson presents analytical data in Table 7 that utilizes the ionized mass results from a LCMS (liquid chromatograph mass spec) examination of example 2 to derive a few structures of example 2's composition. Example 2 is the reaction products of ammonia, dicyandiamide and urea with formaldehyde, wherein the reaction medium is water. Below in Table 1 is a complete listing of the potential structures for the remaining ionized mass results that were not identified:

TABLE 1 LCMS Spectral Peak Identification Peak Ionized Mass + # Na (23 Da) Proposed Structure 1 148

2 DCD 3 Urea 4 220

5 Unknown/Appears in Nitamin 30 L 6 Unknown/Appears in Nitamin 30 L 7 179

8 251.1

9 261.1

10 244.1

11 155.0 Unknown/Appears in Nitamin 30 L

12 220

13 292.1

14 220

15 196.0 Unknown/Appears in Nitamin 30 L

Upon examination, the data lacks the ionized mass results for methylene bis dicyandiamide (180+23 (Na)=203) and the dicyandiamide-formaldehyde trimer (276 +23(Na)=299). It also shows the presence of unreacted DCD. Gabrielson discloses a composition of the formaldehyde reaction product comprises 0.1 to 10 wt. % of a DCD-formaldehyde-oligomer adduct based upon the weight of the nitrification inhibitor system but the analytical data does not indicate the compound to be present. Gabrielson tests the performance of his innovations as nitrification inhibitors wherein the application levels with urea are based on the DCD content of his examples 1-3. Table 2 show the weight of DCD required for each experiment. Table 2 also translates the weight of DCD utilized in the evaluation into pounds DCD/ton of urea (Standard terminology for Ag Industry).

TABLE 2 *Level of Weight of Weight of Weight of Lbs DCD/ DCD Urea nitrogen DCD ton of urea 0.75% 2.15 0.989 0.00742 6.90 1.50% 2.15 0.989 0.01484 13.80 3.00% 2.15 0.989 0.02967 27.60 *based on nitrogen content of urea **urea is approximately 46% nitrogen The expected % DCD content of each example based on the given weights in each examples including the distillation loss of Example 2 was calculated. Table 3 shows the expected weights of each example in the performance experiments as well as translating these weights into pounds/ton of urea (Standard terminology for the Ag Industry)

TABLE 3 0.75% DCD on N 1.5% DCD on N 3.0% DCD on N value of urea value of urea value of urea Expected grams of Lbs of grams of Lbs of grams of Lbs of % DCD Example Example/ Example Example/ Example Example/ Example (Bound in 500 ml ton of in 500 ml ton of in 500 ml ton of # and free) solution urea solution urea solution urea 1 38.36% 0.0193 17.987 0.039 35.97 0.077 71.95 2 7.98% 0.0930 86.466 0.186 172.93 0.372 345.86 3 18.58% 0.0399 37.137 0.080 74.27 0.160 148.55 The resulting evaluation on the effectiveness of the nitrification inhibition by the experimental samples showed that example 2 was more effective versus examples 1 and 3 and example #2 was equivalent to C2 (DCD & Urea) but only at the application level of 3% DCD based on the nitrogen content of urea. Example 2 performed poorer versus DCD at lower levels. Earlier work in U.S. Non-Provisional application Ser. No. 15/641,264 (McKnight) filed Jul. 4, 2017 (to which the present invention claims priority) discussed the use of an aprotic non-aqueous ogano solvent delivery system NOSDS comprising one or more aprotic solvents that can serve as the reaction medium for the formation of biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds. McKnight also detailed a process wherein said biodegradable, hydrophobic polymer involves 1) dissolving the nitrogen containing compound into an aprotic NOSDS at temperatures of 10-140° C. wherein the composition is cooled to 30-60° C. 2) the aldehydes are charged at a rate that controls the exotherm with 5-20° C. of the reaction temperature that is 30-90° C. in a molar ratio of aldehyde to aldehyde reactive sites on the nitrogen containing compound of (0.10 −0.90)/1.0. 3) The reaction is held at 30−70° C. and at a pH of 7.5-10.0 for 5 to 12 hours until the free formaldehyde is 40,000 to 5,000 ppm's. 4) The reaction is heated to 70-100° C., the pH is adjusted to 4.0-8.0 and held until free formaldehyde is <700 ppm, wherein the composition is cooled to less than 40° C. and packaged. McKnight also stated that the resulting biodegradable, hydrophobic polymer dispersed within the aprotic NOSDS imparted good water resistant properties to urea. However, it has been determined that the reaction conditions to produce these biodegradable polymers/oligomers were too aggressive for cyano-containing nitrification inhibitors resulting in the conversion of the cyano-group to a carbamide function impacting solubility and most importantly, nitrification inhibition. Also McKnight demonstrated urea-formaldehyde reactions utilizing dimethyl sulfoxide as the reaction medium in Examples 17 and 18.

Thus, there is a need to for compositions and an improved method of making liquid fertilizer additives of biodegradable polymers and/or oligomers comprised of the reaction products of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups.

Although the concept of creating a larger molecular weight nitrification inhibitor would assist in slowing its migration through the soil, the industry needs a product that is economical, effective at lower application levels and utilizes a liquid delivery system that is non-aqueous in order to be utilized in all nitrogen source application techniques. It would also be beneficial to have a method to make a modified urea in situ during the urea manufacturing/particle formation processes wherein a liquid fertilizer additive comprising partially reacted/unreacted nitrification inhibitors—aldehyde compositions is added to the molten urea utilizing a non-aqueous polar, aprotic solvent system. Moreover it is beneficial to have urea and ammonia have good solubility in the delivery vehicle. In a variation, the liquid fertilizer additive is added to anhydrous ammonia, a molten pool of urea and/or a molten pool of urea that is either in an ammonia atmosphere, has ammonia dissolved within the molten pool or that has ammonia added during the charge of the liquid fertilizer additive.

SUMMARY OF THE INVENTION

In embodiments, the present invention relates to liquid formulations containing hydrophobic, biodegradable polymers dispersed within a Non-aqueous Organic Solvent Delivery System (NOSDS) and is designed to coat fertilizer granules with a hydrophobic film utilizing simple application equipment such as mixers, blenders and tumblers. This film can impede the dissolution of fertilizer components by water improving fertilizer efficiency. The NOSDS can be aprotic solvents, protic solvents and mixtures of protic and aprotic solvents which are environmentally friendly, have flashpoints above 145° F., and are inherently rated safe for contact with humans and animals. The hydrophobic polymers are the reaction product of aldehyde(s) and nitrogen containing compounds.

In an embodiment, the present invention relates to compositions and an improved method of making liquid fertilizer additives of biodegradable polymers and/or oligomers comprised of the reaction products of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, wherein the cyano-group is conserved.

The present invention also relates to a method of making non-aqueous liquid fertilizer additives that are comprised of high levels of biodegradable polymers and/or oligomers, especially methylene bus nitrification inhibitor (NI) oligomers as shown below: (2 moles) NI+(1 mole) formaldehyde unit→NI-CH₂—NI+H₂O wherein the reaction of aldehyde(s) with non-cyano- and/or cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols utilizing a non-aqueous polar, aprotic organo liquid (abbreviated as NAPAOL) as the reaction medium to produce compounds overcoming performance deficiencies related to atmospheric volatility or migration through the soil due to water solubility and low molecular weight. It is thought that these methylene bis NIs as well as polymeric NIs have nitrification inhibition properties as well as providing nitrification inhibition through a slow release mechanism of biodegradation of the oligomer and/or polymer that releases the polymer bound nitrification inhibitor. The utility of a NAPAOL as the reaction medium allows aldehyde reactions with non-cyano-containing nitrification inhibitors that have been previously unavailable due to the poor water solubility of the non-cyano-containing nitrification inhibitors.

The capability of the NAPAOL to also serve as a non-aqueous organo solvent delivery system (abbreviated as NOSDS) allows the application of the liquid composition to nitrogen sources that utilize moisture sensitive application methods. It has been learned that liquid fertilizer additives of biodegradable polymers and/or oligomers comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary and secondary amines, b) amides, c) thiols, d) hydroxyls and e) phenols assist to conserve the cyano-group. It has also unexpectedly learned that the liquid fertilizer additives of biodegradable polymers and/or oligomers comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary and secondary amines, b) amides, c) thiols, d) hydroxyls and e) phenols, wherein the resulting product can possesses higher levels of polymer bound and free nitrification inhibitors versus products utilizing a NAPAOL to make solutions of free nitrification inhibitors. In a variation, it has been learned that utilizing a NAPAOL as the reaction medium results in higher compositional weight percent of said biodegradable polymers and/or oligomers versus those produced in an aqueous medium.

In embodiments, the present invention relates to liquid formulations comprising nitrification inhibitors chemically bound within a polymer/oligomer, dispersed within a Non-aqueous Organic Solvent Delivery System (abbreviated as NOSDS) for application to nitrogen sources. The method of making these polymeric and/or oligomeric nitrification inhibitors comprise a non-aqueous polar, aprotic organo liquid (abbreviated as NAPAOL) that is utilized as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols and wherein the process parameters are optimized for conserving the cyano group. A non-aqueous solvent delivery system (NOSDS) can be utilized to improve the physical properties of the liquid formulation wherein the NOSDS comprises the reaction medium, NAPAOL, aprotic solvents and protic solvents which are environmentally friendly, have flashpoints above 145° F. and are inherently rated safe for contact with humans and animals.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

FIG. 1 is the plot of DCD concentration in samples of the present invention versus UV absorbance @ 211-216 nm.

FIG. 2 is an FTIR scan of Example 76.

FIG. 3 is an FTIR scan of Example 74.

FIG. 4 is an FTIR scan of Example 79

FIG. 5 is an FTIR scan of a 34% solution of Dicyandiamide in DMSO

FIG. 6 is a graph of nitrification inhibition properties of Examples 73 and 76 versus dicyandiamide

FIG. 7 is a graph on the impact of the presence of the cyano group on nitrification inhibition properties

FIG. 8 is the nitrification inhibition property of Example 75 versus dicyandiamide.

FIG. 9 is the chromatogram of Example 76.

FIG. 10 is the mass spectra of Example 76.

FIG. 11 is the chromatogram of Example 78.

FIG. 12 is the mass spectra of Example 78.

DETAILED DESCRIPTION OF THE INVENTION Definitions

cyano-containing nitrification inhibitor: nitrogen containing compounds that have nitrification inhibition properties and contain one or more cyano-groups.

non-cyano-containing nitrification inhibitor: nitrogen containing compounds that have nitrification inhibition properties and contain no cyano-groups.

NAPAOL (non-aqueous polar, aprotic organo liquid): an aprotic NOSDS (non-aqueous organo solvent delivery system) that is used specifically as the reaction medium.

biologics: although utilized as bio-active agents are specified as a different category due to their definition as naturally occurring substances, substances produced by natural processes such as fermentation and/or extracts of naturally occurring substances. nitrogen sources: one or more compounds and/or substances selected from the group consisting of: urea, urea formaldehyde reaction products, ammonia, urea formaldehyde and ammonia reaction products, ammonium nitrate, ammonium sulfate, manure and compost. treated nitrogen source: a composition comprising a nitrogen source and biologically active agents and/or biologics added either through a coating application or added to the nitrogen source during the nitrogen source's production process either in the melt portion or applied to the nitrogen source during the formation of the nitrogen source's granule. Polymer weight or polymer composition weight refers to the nitrification inhibitor weight. Dimethylene ether: is a chemical structure represented by —CH₂—O—CH₂— formed by the reaction of two methylol functionalities and is a term used to describe crosslinks between individual biodegradable polymeric and/or oligomeric nitrification inhibitors. It exhibits low formaldehyde properties and is a high temperature reactive crosslink that is reactive to organo compounds that contain one or more aldehyde reactive groups selected from the group consisting of a) primary amines b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols at temperatures ranges of about 80-140° C. BPONI: is an acronym for liquid additive compositions for fertilizers comprised of one or more biodegradable polymeric and/or oligomeric nitrification inhibitors wherein the aldehyde-nitrification inhibitor adduct formation utilizes a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols.

In one embodiment, the present invention relates to liquid formulations comprised of hydrophobic, biodegradable polymers and a Non-aqueous Organic Solvent Delivery System (NOSDS) and is designed to coat fertilizer granules with a hydrophobic film utilizing simple application equipment such as mixers, blenders and tumblers A NOSDS is comprised of a) one or more protic solvents from the group consisting of: 1) an alcohol from the family of C₁₋₁₀ alkanols, 2) one or more polyols from the group consisting of trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol and sorbitan, glucose, fructose, galactose, and glycerin, 3) poly(C₁₋₁₀ alkylene) glycols, 4) one or more alkylene glycols from the group consisting of ethylene glycol, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, 5) isopropylidene glycerol 6) one or more alkylene glycol alkyl ethers represented by the structure:

-   -   where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉     -   where R² is: H or

-   -   where R³ is: H or CH₃     -   where R⁴ is H and/or CH₃     -   and f is an integer between 1 and 15         7) one or more alkyl lactates from the group consisting of         ethyl, propyl and butyl lactate,         8) one or more alkanolamines represented by the structure:

-   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH     -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH     -   where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH     -   where R⁸ is: (C₂H₄O)_(g)H     -   and g is an integer between 1-10         and 9) glycerol carbonate.         b) and/or one or more aprotic solvents from the group consisting         of 1) dimethyl sulfoxide and/or 2) dialkyl, diaryl, or alkylaryl         sulfoxide(s) having the formula:         R₉S(O)_(x)R₁₀     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ with the         sulfur to which they are attached form a 4 to 8 membered ring         wherein R₉ and R₁₀ together are a C₁₋₆ alkylene group which         optionally contains one or more atoms selected from the group         consisting of O, S, Se, Te, N, and Pin the ring and x is 1 or 2.         3) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, 4) one or more polyols capped with acetate         or formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 5) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and/or tripropylene         glycol butyl ether acetate and, 6) isophorone, 7) one or more         diesters consisting of dimethylsuccinate, dimethyl adipate,         diethyl glutarate, and dimethyl glutarate, 8)         dimethylacetamide, 9) dimethylformamide, 10)         dimethyl-2-imidazolidinone, 11) 1-Methyl-2-pyrrolidone, 12)         hexamethylphosphoramide, 13) 1,2-dimethyloxyethane, 14)         2-methoxyethyl ether, 15)cyclohexylpyrrolidone and 16) limonene.

In one embodiment, the biodegradable, hydrophobic polymers are the reaction product of aldehyde(s) and nitrogen containing compounds. In an embodiment, the aldehyde(s) comprising one or more of the group consisting of:

-   -   Q is: O, S     -   Where R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —CH═CH₂,         —C₄H₃O, —C₇H₇, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O, C₃H₅O, C₄H₇O, C₇H₅O or         —R¹²O₂R¹³,     -   Where R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₈, —C₆H₁₀     -   Where R¹³ is: —H, CH₃, C₂H₃, C₃H₇, C₄H₉         In one embodiment, the nitrogen containing compounds comprising         one or more of the group consisting of.

-   -   A is: O, S     -   where R¹⁴ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(a) NH₂         -   Where a is an integer: 1-10     -   where R¹⁵ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(b) NH₂         -   Where b is an integer: 1-10     -   where R¹⁶ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(c) NH₂         -   Where c is an integer: 1-10     -   where R¹⁷ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(d) NH₂         -   Where d is an integer: 1-10             and

and their tautomeric forms and

Where X₁ is: —NHR¹⁸, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃

-   -   Where R¹⁸ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,     -   C₂H₄OC₂H₄NH₂,     -   C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         Where X₂ is: —NHR¹⁹, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R¹⁹ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂,     -   —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         Where X₃ is: —NHR²⁰, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R²⁰ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂,     -   —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         and         NH₂CO—R²¹         where R²¹ is an alkyl radical CH3 to —C17H35

In a variation, an aldehyde can be reacted with a nitrogen containing compound to form a new monomer. A non-limiting example would be the chemical Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione from the reaction of 2 moles of urea and one mole of ethandial and represented by the structure:

In another variation, the monomeric reaction product of an aldehyde and a nitrogen containing compound can be capped with a C alkanol group creating a low temperature crosslinking product.

Non-limiting examples would be

1,3,4,6-Tetrakis(methoxymethyl)glycoluril from the reaction of one mole of Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione with four moles of methanal and then capping with four moles of methanol.

N,N,N′,N′,N″,N″-Hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triamine from the reaction of one mole of 1,3,5-triazine-2,4,6-triamine with 6 moles of methanal and then capping with six moles of methanol.

Tetra(methoxymethyl) urea from the reaction of 1 mole of urea with four mole of methanal and then capped with four moles of methanol.

In one embodiment, the biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds contain polyamines such as but not limited to ethylenediamine, diethylenetriamine, triethylenetetramine tetraethylenepentamine and aminoethylethanolamine and/or polyol compounds such as but not limited to one or more polyols from the group consisting of trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol and sorbitan, glucose, fructose, galactose, and glycerin, 3) poly(C₁₋₁₀ alkylene) glycols, 4) one or more alkylene glycols from the group consisting of ethylene, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, 5) isopropylidene glycerol 6) one or more alkylene glycol alkyl ethers from the group consisting of tripropylene glycol methyl ether, tripropylene glycol butyl ether, dipropylene glycol butyl ether and tripropylene glycol butyl ether constituting 0.1-5% of its polymer weight in order to modify the coatings' properties such as hydrophobicity, coverage, flexibility of the formed film. The polymer weight means the nitrification inhibitor weight.

In one embodiment, the biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds contain secondary amines such as diethanolamine, diethylamine, cyclohexylamine, methylethanolamine, diisopropanolamine, methylispropylamine and small molecular weight alcohols such as but not limited to methanol, ethanol, butanol, and hexanol to assist in controlling the molecular weight build of the biodegradable, hydrophobic polymer through chain termination

In one embodiment, the biodegradable, hydrophobic polymers are the reaction product of aldehyde(s) and nitrogen containing compounds in which the aldehyde(s) comprising one or more of the group consisting of:

-   -   methanal, ethanal, propanal, butanal, pentanal, hexanal,         methylethanal, methylpropanal, methylbutanal,         phenylacetaldehyde, benzaldehyde, 2-propenal, 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid, 6-oxohexanoic acid, 2-oxopropanal,         cyclohexanal, furfural     -   methyl esters of 3-oxopropanoic, 2-methyl-3-oxopropanoic acid,         4-oxobutanoic acid, oxoacetic acid, 5-oxopentanoic acid and         6-oxohexanoic acid, ethandial, 1,3-propanedial, butanedial,         pentanedial, phthalaldehyde and methanethial         and nitrogen containing compounds comprising one or more of the         group consisting of:     -   urea, biuret, polyurea, thiourea, methylurea, dimethylurea,         ethylurea, diethylurea, propylurea, dipropylurea, butylurea,         dibutylurea, phenylurea, diphenyl urea, pentylurea,         dipentylurea, hexyl urea, dihexyl urea, methylthiourea,         dimethylthiourea, ethylthiourea, diethylthiourea,         propylthiourea, diporpylthiourea, butylthiourea,         dibutylthiourea, pentylthiourea, dipentylthiourea,         hexylthiourea, dihexylthiourea, phenylthiourea,         diphenylthiourea, cyanamide, dicyandiamide, tricyantriamide,         melamine, hydroxy oxypentyl melamine, methylaminomelamine,         dimethylaminopropylmelamine, 1,3,5-Triazine-2,4,6 triamine, 2,         4-diamino-1, 3, 5-triazine, 2,4-diol-6-Amino-1,3,5-triazine,         2,4-Diamino-6-hydroxy-1,3,5-triazine,         2-Butylamino-4,6-diamino-1,3,5-triazine,         2,4-Diamino-6-methyl-1,3,5-triazine,         2,4-Diamino-6-dimethylamino-1,3,5-triazine,         2-Amino-1,3,5-triazine, ethanamide, propanamide, butanamide,         pentanamide, hexanamide, heptanamide, octanamide, nonanamide,         decanamide, dodecanamide, tetradecanamide, hexadecanamide, and         octadecanamide, ammonia, monoethanolamine, diglycolamine,         ethylamine,

In one embodiment, the NOSDS of the present invention meet one or more of the following criteria: They are:

-   -   environmentally safe;     -   thermally safe because they have flashpoints above 145° F.;     -   inherently rated safe for contact with humans and animals;     -   able to maintain biodegradable, hydrophobic polymers that are         the reaction product of aldehyde(s) and nitrogen containing         compounds at levels of 1-50% in solution to temperatures down to         at least 10° C. This property means that these compositions have         improved shelf storage lives.     -   able to provide improved and even application to fertilizer         granules of biodegradable, hydrophobic polymers that are the         reaction product of aldehyde(s) and nitrogen containing         compounds while not causing clumping of the granules.

In an embodiment, low molecular weight biodegradable, hydrophobic oligomers (LMWBHO) with a molecular weight range of 50-1000 daltons from the reaction of aldehyde(s) and nitrogen containing compounds can be produced utilizing an aprotic NOSDS as the reaction medium. In a variation, the molar ratios of aldehyde groups to aldehyde reactive nitrogens are 0.1-1.5/0.5-1.5. In another variation, these LMWBHOs can be blended with one or more monomeric reaction products of an aldehyde and a nitrogen containing compound that have been alkoxy capped at a weight ratio of 99.9-90%/0.1-10% of LMWBHO/alkoxy capped monomers. This blend can be applied to the surface of fertilizer granules, then exposed to temperatures 25-100° C. causing crosslinking reaction to occur between the alkoxy capped monomers and the LMWBHO. In a variation, those skilled in the art can add a catalyst such as

-   -   methane sulfonic acid, sulfuric acid, para-toluene sulfonic         acid. phosphoric acid and methane phosphonic acid         to the coating formulation to improve reactivity and conversion.         In a variation, the alkoxy capped monomers comprise one or more         of the group consisting of         1,3,4,6-tetrakis(methoxymethyl)glycoluril,         N,N,N′,N′,N″,N″-hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triamine,         tetra(methoxymethyl) urea and di(methoxymethyl) urea. In another         variation, an aprotic NOSDS is chosen such as but not limited to         DMSO that also solubilizes the surface of urea granules allowing         the crosslinking action to include the surface of urea allowing         the coating to be chemical bonded to the surface of the urea         granule. In a variation, a protic NOSDS can be added to improve         the coating properties such as but not limited to viscosity and         hydrophobicity.

Additionally, the delivery formulations of the present invention may contain one or more of the following:

-   -   a food coloring or dye that may be used to improve the visual         evidence of complete coverage and serve as a visual marker;     -   scents or masking agents to improve the odor of the         formulations;     -   Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   Buffering agents.     -   Catalyst(s) to improve reaction completion

In an embodiment, an aprotic NOSDS comprising of one or more aprotic solvents from the group consisting of 1) Dimethyl Sulfoxide and/or 2) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the formula: R₁S(O)xR₂

-   -   wherein R₁ and R₂ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₁ and R₂ with the         sulfur to which they are attached form a 4 to 8 membered ring         wherein R₁ and R₂ together are a C₁₋₆ alkylene group which         optionally contains one or more atoms selected from the group         consisting of O, S, Se, Te, N, and Pin the ring and x is 1 or 2.         3) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, 4) one or more polyols capped with acetate         or formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 5) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and/or tripropylene         glycol butyl ether acetate and, 6) isophorone, 7) one or more         diesters consisting of dimethylsuccinate, dimethyl adipate,         diethyl glutarate, and dimethyl glutarate, 8)         dimethylacetamide, 9) dimethylformamide, 10)         dimethyl-2-imidazolidinone, 11) 1-Methyl-2-pyrrolidone, 12)         hexamethylphosphoramide, 13) 1,2-dimethyloxyethane, 14)         2-methoxyethyl ether, 15)cyclohexylpyrrolidone and 16) limonene         can serve as the reaction medium for the formation of         biodegradable, hydrophobic polymers that are the reaction         product of aldehyde(s) and nitrogen containing compounds In an         embodiment the aldehyde(s) comprise one or more of the group         consisting of:

-   -   Q is: O, S     -   Where R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —CH═CH₂,         —C₄H₃O, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O, C₃H₅O, C₄H₇O, C₇H₅O or         —R¹²O₂R¹³,     -   Where R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₈, —C₆H₁₀     -   Where R¹³ is: —H, CH₃, C₂H₃, C₃H₇, C₄H₉         and nitrogen containing compounds comprising one or more of the         group consisting of:

-   -   A is: O, S     -   where R¹⁴ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(a) NH₂         -   Where a is an integer: 1-10     -   where R¹⁵ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(b) NH₂         -   Where b is an integer: 1-10     -   where R¹⁶ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(c) NH₂         -   Where c is an integer: 1-10     -   where R¹⁷ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(d) NH₂         -   Where d is an integer: 1-10             and

and their tautomeric forms and

where X₁ is: —NHR¹⁸, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃

-   -   Where R¹⁸ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂,     -   —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         where X₂ is: —NHR¹⁹, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R¹⁹ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂,     -   —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         where X₃ is: —NHR²⁰, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R²⁰ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂,     -   —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         and         NH₂CO—R²¹         Where R²¹ is an alkyl radical CH3 to —C17H35

In a variation, those skilled in the art can add a catalyst such as;

-   -   methane sulfonic acid, sulfuric acid, para-toluene sulfonic         acid. phosphoric acid and methane phosphonic acid         to the coating formulation to improve reactivity and conversion.         In a variation an aldehyde can be reacted with a nitrogen         containing compound within an aprotic NOSDS to form a new         monomer. A non-limiting example would be the chemical         Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione from the         reaction of 2 moles of urea and one mole of ethandialal and         represented by the structure:

In another variation, the monomeric reaction product of an aldehyde and a nitrogen containing compound can be capped with an C₁-C₄ alkanol group utilizing an aprotic NOSDS as a reaction medium creating a low temperature crosslinking product. Non-limiting examples would be

1,3,4,6-Tetrakis(methoxymethyl)glycoluril from the reaction of one mole of Tetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione with four moles of methanal and then capping with four moles of methanol.

N,N,N′,N′,N″,N″-Hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triamine from the reaction of one mole of 1,3,5-triazine-2,4,6-triamine with 6 moles of methanal and then capping with six moles of methanol.

Tetra(methoxymethyl) urea from the reaction of 1 mole of urea with four mole of methanal and then capped with four moles of methanol.

In one embodiment, the biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds formed within an aprotic NOSDS that serves as the reaction medium contains polyamines compounds such as but not limited to ethylenediamine, diethylenetriamine, triethylenetetramine tetraethylenepentamine and aminoethylethanolamine and/or polyol compounds such as but not limited to one or more polyols from the group consisting of trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol and sorbitan, glucose, fructose, galactose, and glycerin, 3) poly(C₁₋₁₀ alkylene) glycols, 4) one or more alkylene glycols from the group consisting of ethylene, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, 5) isopropylidene glycerol 6) one or more alkylene glycol alkyl ethers from the group consisting of tripropylene glycol methyl ether, tripropylene glycol butyl ether, dipropylene glycol butyl ether and tripropylene glycol butyl ether constituting 0.1-5% of its polymer weight in order to modify the coatings' properties such as hydrophobicity, coverage, flexibility of the formed film.

In one embodiment, the biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds formed within an aprotic NOSDS that serves as the reaction medium contains secondary amines such as diethylamine, diethanolamine, methylethanolamine, diisopropanolamine, Methylispropylamine and cyclohexylamine and small molecular weight alcohols such as but not limited to methanol, ethanol, butanol hexanol to assist in controlling the molecular weight build of the biodegradable, hydrophobic polymer through chain termination.

In a variation, a protic NOSDS can be added to improve the coating properties such as but not limited to viscosity and hydrophobicity.

Additionally, the delivery formulations of the present invention may contain one or more of the following:

-   -   a food coloring or dye that may be used to improve the visual         evidence of complete coverage and serve as a visual marker;     -   scents or masking agents to improve the odor of the         formulations;     -   Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   Buffering agents.     -   Catalyst(s) to improve reaction completion.

In an embodiment, an aprotic NOSDS comprising of one or more aprotic solvents from the group consisting of 1) Dimethyl Sulfoxide and/or 2) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the formula: R₁S(O)xR₂

-   -   wherein R₁ and R₂ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₁ and R₂ with the         sulfur to which they are attached form a 4 to 8 membered ring         wherein R₁ and R₂ together are a C₁₋₆ alkylene group which         optionally contains one or more atoms selected from the group         consisting of O, S, Se, Te, N, and P in the ring and x is 1 or         2,         3) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, 4) one or more polyols capped with acetate         or formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 5) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and/or tripropylene         glycol butyl ether acetate and, 6) isophorone, 7) one or more         diesters consisting of dimethylsuccinate, dimethyl adipate,         diethyl glutarate, and dimethyl glutarate, 8)         dimethylacetamide, 9) dimethylformamide, 10)         dimethyl-2-imidazolidinone, 11) 1-Methyl-2-pyrrolidone, 12)         hexamethylphosphoramide, 13) 1,2-dimethyloxyethane, 14)         2-methoxyethyl ether, 15)cyclohexylpyrrolidone and 16) limonene.

These can serve as the reaction medium for the formation of biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds with a molecular weight range of 1000-200,000 daltons in a molar ratio of aldehyde groups to aldehyde reactive nitrogens on the nitrogen containing compound of (0.10-0.90)/1.0. The process to make said biodegradable, hydrophobic polymer involves (1) dissolving the nitrogen containing compound into an aprotic NOSDS at temperatures of 10-140° C. wherein the composition is cooled to 30-60° C. 2) the aldehydes are charged at a rate that controls the exotherm with 5-20° C. of the reaction temperature that is 30-90° C. in a molar ratio of aldehyde to aldehyde reactive sites on the nitrogen containing compound of (0.10-0.90)/1.0. 3) The reaction is held at 30-70° C. and at a pH of 7.5-10.0 for 5 to 12 hours until the free formaldehyde is 40,000 to 5,000 ppm's. 4) The reaction is heated to 70-100° C., the pH is adjusted to 4.0-8.0 and held until free formaldehyde is <700 ppm, wherein the composition is cooled to less than 40 C and packaged.

In an embodiment the aldehyde(s) comprise one or more of the group consisting of:

-   -   methanal, ethanal, propanal, butanal, pentanal, hexanal,         methylethanal, methylpropanal, methylbutanal,         phenylacetaldehyde, benzaldehyde, 2-propenal, 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid, 6-oxohexanoic acid, 2-oxopropanal,         cyclohexanal, furfural,     -   methyl esters of 3-oxopropanoic, 2-methyl-3-oxopropanoic acid,         4-oxobutanoic acid, oxoacetic acid, 5-oxopentanoic acid and         6-oxohexanoic acid, ethandial, 1,3-propanedial, butanedial,         pentanedial, phthalaldehyde and methanethial

In a variation the aldehydes comprise one or more from the group consisting of the structure:

-   -   Where Q is: O, S     -   Where R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —CH═CH₂,         —C₄H₃O, —C₇H₇, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O, C₃H₅O, C₄H₇O, C₇H₅O or         —R¹²O₂R¹³,     -   Where R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₈, —C₆H₁₀     -   Where R¹³ is: —H, CH₃, C₂H₃, C₃₁₁₇, C₄H₉         and nitrogen containing compounds comprising one or more of the         group consisting of:     -   urea, biuret, polyurea, thiourea, methylurea, dimethylurea,         ethylurea, diethylurea, propylurea, dipropylurea, butylurea,         dibutylurea, phenylurea, diphenyl urea, pentylurea,         dipentylurea, hexyl urea, dihexyl urea, methylthiourea,         dimethylthiourea, ethylthiourea, diethylthiourea,         propylthiourea, diporpylthiourea, butylthiourea,         dibutylthiourea, pentylthiourea, dipentylthiourea,         hexylthiourea, dihexylthiourea, phenylthiourea,         diphenylthiourea, cyanamide, dicyandiamide, tricyantriamide,         melamine, hydroxy oxypentyl melamine, methylaminomelamine,         dimethylaminopropylmelamine, 1,3,5-Triazine-2,4,6 triamine, 2,         4-diamino-1, 3, 5-triazine, 2,4-diol-6-Amino-1,3,5-triazine,         2,4-Diamino-6-hydroxy-1,3,5-triazine,         2-Butylamino-4,6-diamino-1,3,5-triazine,         2,4-Diamino-6-methyl-1,3,5-triazine,         2,4-Diamino-6-dimethylamino-1,3,5-triazine,         2-Amino-1,3,5-triazine, ethanamide, propanamide, butanamide,         pentanamide, hexanamide, heptanamide, octanamide, nonanamide,         decanamide, dodecanamide, tetradecanamide, hexadecanamide, and         octadecanamide

In a variation, the nitrogen containing compounds comprising one or more of the group consisting of the structures:

a)

-   -   Where A is: O, S     -   Where R¹⁴ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(a) NH₂     -   Where a is an integer: 1-10     -   Where R¹⁵ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(b) NH₂     -   Where b is an integer: 1-10     -   Where R¹⁶ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(c) NH₂     -   Where c is an integer: 1-10     -   Where R¹⁷ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(d) NH₂     -   Where d is an integer: 1-10,         b)

and their tautomeric forms,

c)

-   -   Where X₁ is: —NHR¹⁸, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R¹⁸ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅     -   Where X₂ is: —NHR¹⁹, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R¹⁹ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅     -   Where X₃ is: —NHR²⁰, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   Where R²⁰ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         and d)     -   NH₂CO—R²¹     -   Where R²¹ is an alkyl radical CH₃ to —C₁₇H₃₅         In a variation, a protic NOSDS can be added to improve the         coating properties such as but not limited to viscosity and         hydrophobicity.

Additionally, the delivery formulations of the present invention may contain one or more of the following:

-   -   a food coloring or dye that may be used to improve the visual         evidence of complete coverage and serve as a visual marker;     -   scents or masking agents to improve the odor of the         formulations;     -   Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   Buffering agents.     -   Catalyst(s) to improve reaction completion.

In one embodiment, hydrophobic, biodegradable polymers powders are added to the NOSDS under agitation, In a variation, one can aid in the dissolution of the polymer into the NOSDS by using temperatures of 15-140° C.

In another variation one can add a small amount of a surfactant to improve wetting and dispersion of the polymer into the NOSDS. In another variation one can use high shear devices such but not limited to a cowles dissolver, rotor/stator high shear units or a homogenizer to improve the polymer dispersion into NOSDS as well as its physical properties such as viscosity. In another variation one can use any combination of such methods.

In one embodiment one can add a hydrophobic, biodegradable polymer that is dispersed in a liquid into a NOSDS. In a variation if the liquid system does not meet the criteria of NOSDS, it can be displaced with a suitable NOSDS through differential boiling points by temperature and/or reduced pressure.

In one embodiment one skilled in the art can produce a hydrophobic, biodegradable polymer within an aprotic NOSDS. In a variation, the resulting product can be further diluted with a protic NOSDS. In another variation, the resulting product can be further diluted with an aprotic NOSDS. In another variation, the resulting product can be further diluted with a protic and an aprotic NOSDS

In an embodiment the NOSDS not only provide the solvating property for the hydrophobic, biodegradable polymer but is also the delivery system for the hydrophobic, biodegradable polymers to the surface of fertilizer granules.

In one embodiment, the liquid formulation containing biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds and NOSDS is used to coat a dry granular fertilizer, which is then applied to cropland and turf. The hydrophobic coating makes the fertilizer more effective in providing nutrients for plant growth over an extended period of time. In a variation, flow modifiers such as but not limited to silicas, powdered lime or a powdered micronutrient salt can be added to the coated fertilizer to improve granules' flow properties.

In one embodiment, coated granular fertilizer products containing additional plant nutrients can be prepared from granular fertilizer, a source or sources of the additional nutrients in powdered form described below. Granular fertilizer can be mixed to distribute the liquid mixture over the granular fertilizer surface using any commonly used equipment to co-mingle a liquid with a granular solid. After distribution of mixture over the granular surface, the additional nutrients in powdered form can be added to the dampened mixture and the resulting combined ingredients can be further mixed to distribute the powdered materials. In an alternate embodiment, the powdered materials may be first mixed with the granular urea and then the solution can be sprayed onto a tumbling bed of the dry ingredients to agglomerate the dry materials. This latter method may be particularly suited to continuous processing. In an embodiment, the formulations use combinations of polar aprotic solvents (sulfoxides, sulfones, dialkyl carbonates) with protic solvents (glycols, triols, and alkanolamines) to produce formulations having acceptable viscosity levels, hydrophobicity and be relatively non-toxic.

In one embodiment, formulations are used to fluidize the biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds and coat the fertilizer granules with a water-resistance layer, which can impede to dissolution of the water soluble components of fertilizer and slow down the leaching of nutrients into soil.

In one embodiment, biodegradable, hydrophobic polymers that are the reaction product of aldehyde(s) and nitrogen containing compounds will degrade in the soil and the degradation product becomes a source of nitrogen fertilizer over time.

The mixing of the materials may be accomplished in a simple mixing tank mixing materials prior to use, using a metering system to inject materials simultaneously, or mixing via a spray injection system.

The mixture can be mixed in any common mixing tank, blenders and tumblers or on a conveyer belt. Although the metering of all ingredients can be based on a weight, it may also be based on a volumetric basis.

A dye or colorant can be added to the mixture to aid in visual assessment of uniform coating during the coating of granular urea. Alternatively, a dye or colorant can be added to the mixture to aid in visual assessment of uniform coating during the coating of urea in aqueous mixtures just prior to application. In one embodiment, the colorant can include any nontoxic common food dye.

In an embodiment, the method to make liquid additives compositions for fertilizers comprises utilizing a NAPAOL as the reaction medium for the formation of cyano-containing nitrification inhibitors—aldehydes adducts. In a variation, the reaction of one or more aldehyde(s) with one or more cyano-containing nitrification inhibitors that contain one or more aldehyde reactive groups selected from the group consisting of a) primary amines b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, comprises that the one or more aldehydes is selected from the group consisting of paraformaldehyde, formaldehyde and 1,3,5-trioxane, and the cyano-containing nitrification inhibitors comprises dicyandiamide (DCD). In an embodiment, the formaldehyde reaction with DCD is a two-step process wherein the first step is the formation of methylol functionalities.

The second step is the reaction of the methylol functionalities with the nitrogens represented by H₂N—C—NH₂ on the DCD that is catalyzed by adjusting the pH (10%) of the contents to 7.0-8.5 with the addition of an acidic compound.

Without being bound by theory, the formation of the dimethylene ether functionalities is a side reaction that occurs within this pH range between two DCD-formaldehyde adducts wherein each adduct contains methylol functionalities.

In an embodiment, dimethylene ethers, in the presence of liquid/molten nitrogen sources that are at temperatures ranges of about 80-140° C., 90-140° C., 90-130° C., 90-120° C., 90-110° C., 90-100° C., 100-140° C., 110-140° C., 120-140° C., or 130-140° C., can react with the nitrogen sources if the nitrogen sources have one or more aldehyde reactive groups selected from the group consisting of a) primary amines b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a variation, nitrogen sources comprised of two or more of said reactive groups can crosslink the biodegradable polymeric and/or oligomeric nitrification inhibitors that contain dimethylene ether functionalities within their structures. In an embodiment, the liquid additive compositions for fertilizers comprised of biodegradable polymeric and/or oligomeric nitrification inhibitors (BPONI) which contain within in their structure one or more methylol functionalities and/or one or more dimethylene ether functionalities are selected from the structure:

is added to molten urea wherein the methylol and dimethylene ether functionalities react with urea.

In an embodiment, Example 17 demonstrates that the reaction of urea with paraformaldehyde can occur utilizing DMSO as the reaction medium without the addition of water to aide in the urea and paraformaldehyde's dissolution. In a variation, BPONIs containing methylol/dimethylene ether functionalities dispersed in DMSO can be added to the surface of hot particles of nitrogen sources wherein the nitrogen sources comprised of one or more aldehyde reactive groups selected from the group consisting of a) primary amines b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols and has some degree of solubility in DMSO, wherein said BPONI containing methylol and/or dimethylene ether functionalities reacts with nitrogen sources forming a nitrogen source-methylene-nitrification inhibitor oligomer structure. In another variation, said BPONIs containing methylol and dimethylene ether functionalities and is dispersed within DMSO are added to a molten urea wherein the said BPONIs for fertilizers containing methylol and dimethylene ether functionalities chemically bonds to urea forming an urea-methylene-nitrification inhibitor oligomer. In a variation, BPONIs containing methylol and dimethylene ether functionalities are then sprayed onto the surface of a hot urea particle forming a chemically modified urea granule.

In an embodiment, the liquid additives compositions for fertilizers comprised of a) BPONIs containing methylol and dimethylene ether functionalities and b) a NOSDS are added to a molten urea wherein the said liquid additives for fertilizers are added during the urea granule manufacturing process. In an embodiment, chemically incorporating said BPONIs containing methylol and dimethylene ether functionalities into urea granule manufacturing processes requires sufficient mixing and time, high enough temperature and low moisture content to insure homogeneous dispersion of said BPONIs containing methylol and dimethylene ether functionalities, complete reaction of said BPONIs containing methylol and dimethylene ether functionalities with urea and to insure minimum degradation of the nitrification inhibitors' cyano-function maintaining their inhibition performance. In an embodiment, methods to make a modified nitrogen sources particles comprises one or more nitrogen source particle formation processes selected from the group consisting of:

1. nitrogen sources drum granulation process:

-   -   a. a rotating drum and molten nitrogen sources with less than 1%         moisture,     -   b. said BPONIs containing methylol and dimethylene ether         functionalities are charged and mixed into the molten nitrogen         sources wherein the BPONIs containing methylol and dimethylene         ether functionalities reacts with the molten nitrogen sources         forming BPONI-modified nitrogen sources,     -   c. the nitrogen sources and BPONI-modified nitrogen sources         mixture is pumped to the spraying nozzles wherein the mixture         continues to react,     -   d. the mixture is then sprayed onto a bed of small nitrogen         sources particles (nitrogen sources particle seed) inside a         rotating drum coating these small nitrogen sources particles         with a thin layer of molten nitrogen sources and BPONI-modified         nitrogen sources,     -   e. forced air is passed over the nitrogen sources particles         removing heat and allowing the thin layer of molten nitrogen         sources/BPONI-modified nitrogen sources to solidify,     -   f. the process is repeated until the desired size of the         nitrogen sources particle is achieved wherein the nitrogen         sources/BPONI-modified nitrogen sources particles are cooled to         ambient temperature and packaged,

2. nitrogen sources fluidized bed granulation process:

-   -   a. utilizes a fluidized bed and molten nitrogen sources with         less than 1% moisture.     -   b. said BPONIs containing methylol and dimethylene ether         functionalities are charged and mixed into the molten nitrogen         sources wherein BPONIs containing methylol and dimethylene ether         functionalities reacts with the molten nitrogen sources forming         BPONI-modified nitrogen sources,     -   c. the nitrogen sources and BPONI-modified nitrogen sources         mixture is pumped to the spraying nozzles wherein the mixture         continues to react,     -   d. the mixture is then sprayed onto a bed of small nitrogen         sources particles (nitrogen sources particle seed) inside a         fluid bed granulator coating these small nitrogen sources         particles with a thin layer of molten nitrogen sources and         BPONI-modified nitrogen sources,     -   e. the rotating or rolling of the small nitrogen sources         particles is accomplished by the use of large volumes of air         blown up through a bed of removing heat and allowing the thin         layer of molten nitrogen sources/BPONI-modified nitrogen sources         to solidify,     -   f. the process is repeated until the desired size of the         nitrogen sources particle is achieved wherein the nitrogen         sources/BPONI-modified nitrogen sources particles are cooled to         ambient temperature and packaged, 3. nitrogen sources prilling         process     -   a. utilizes a prilling tower and molten nitrogen sources with         less than 1% moisture,     -   b. said BPONIs containing methylol and dimethylene ether         functionalities are charged and mixed into the molten nitrogen         sources wherein BPONIs containing methylol and dimethylene ether         functionalities reacts with the molten nitrogen sources forming         BPONI-modified nitrogen sources,     -   c. the nitrogen sources and BPONI-modified nitrogen sources         mixture is pumped to shower generating heads at the top of the         prilling tower wherein the mixture continues to react,     -   d. droplets of the molten nitrogen sources/BPONI-modified         nitrogen sources mixture forms as it passes through the shower         head into the tower     -   e. counter current air flows up the tower cooling the droplets         below the freezing point and thus form small, round, solid         pellets called prills. The nitrogen sources/BPONI-modified         nitrogen sources prills are then cooled and then packaged,     -   wherein the nitrogen sources comprise one or more members         selected from the group consisting of i) urea, ii) ammonia, iii)         ammonium hydroxide, iv) urea formaldehyde reaction products, v)         urea, formaldehyde and ammonia reaction products, vi) ammonium         nitrate, vii) ammonium sulfate, viii) manure ix) monoammonium         phosphate x) diammonium phosphate and xi) compost.         In a variation, the compositional percentages, based on parts by         weight, of the NOSDS of the liquid additives for fertilizers is         in the range of about 10%-40%, 10%-30%, 10-20%, 20-30%, 20-40%         and 30-40%. In a variation, low NOSDS results in nitrogen         sources granules with good physical properties necessary for         efficient and economical distribution of the nitrogen sources         over wide areas. In another variation, a catalyst can be         incorporated with the liquid composition to improve conversion         to a nitrogen source—BPONI adduct,         In an embodiment the general structure of the reaction product         of BPONIs containing methylol and dimethylene ether         functionalities and urea comprises one or more members selected         from the structures consisting of:

In a variation, the composition of BPONIs further comprise unreacted nitrification inhibitors, non-polymeric and/or non-oligomeric nitrification inhibitors that contain methylol and/or dimethylene ether functionalities, formaldehyde, paraformaldehyde and 1,3,5-trioxane. In another variation, the composition of the BPONI can further comprise one or more members selected from the group consisting of:

-   -   1) a food coloring or dye that may be used to improve the visual         evidence of complete coverage and serve as a visual marker;     -   2) scents or masking agents to improve the odor of the         formulations;     -   3) Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   4) Buffering agents.     -   5) Catalyst(s) to improve reaction completion         In an embodiment, the composition BPONIs comprises the reaction         product of paraformaldehyde and dicyandiamide utilizing a NAPAOL         as the reaction medium. In a variation, the composition of         BPONIs further comprise dicyandiamide, dicyandiamide that         contain methylol and dimethylene ether functionalities,         formaldehyde, paraformaldehyde, 1,3,5-trioxane. In another         variation, the composition of BPONIs further comprise         by-products and products of degradation such as formic acid,         formic acid amides, ether bis-methylene structures and         diaminomethylene ureas.         In an embodiment, a method to make BPONIs further comprises a         NOSDS wherein the NOSDS is partially or completely composed of a         NAPAOL wherein the NAPAOL is utilized as the reaction medium for         the reaction of aldehyde(s) with cyano-containing nitrification         inhibitors and/or non-cyano-containing nitrification inhibitors         that have one or more aldehyde reactive functionalities selected         from the group consisting of a) primary amines, b) secondary         amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a         variation, BPONIs containing methylol and dimethylene ether         functionalities are further reacted with organo compounds that         have one or more aldehyde reactive groups selected from the         group consisting of a) primary amines b) secondary amines, c)         amides, c) thiols, e) hydroxyls and f) phenols. In a variation,         said BPONIs containing methylol and dimethylene ether         functionalities is further reacted with a nitrogen containing         compound comprised of one or more members selected from the         group consisting of a) ammonia, b) ammonium hydroxide, c)         primary amines d) secondary amines and e) amides. In another         variation, said BPONIs containing methylol and dimethylene ether         functionalities are further reacted with nitrification         inhibitors that have one or more aldehyde reactive groups         selected from the group consisting of i) primary amines, ii)         secondary amines, iii) amides, iv) thiols, v) hydroxyls and vi)         phenols.         In another variation, said BPONIs containing methylol and         dimethylene ether functionalities are reacted with one or more         monoprotic organo compound selected from the group consisting         of:     -   diethylamine, diethanolamine, methylethanolamine,         diisopropanolamine, methylispropylamine, cyclohexalamine,         methanol, ethanol, butanol, hexanol, isopropylidene glycerol,         tripropylene glycol methyl ether, tripropylene glycol butyl         ether, dipropylene glycol butyl ether and tripropylene glycol         butyl ether, wherein the monoprotic organo compounds does not         promote the extension of the BPONIs molecular weight.         In an embodiment, said BPONIs containing methylol and         dimethylene ether functionalities are contacted with ammonia         and/or ammonium hydroxide at temperatures between 50-120° C.,         wherein the ammonia and or ammonium hydroxide reacts with         methylol functionalities and/or dimethylene ether resulting in a         methylene amino group:         NI-CH₂OH+NH₃→NI-CH₂NH₂+HOH         and/or with a dimethylene ether structure resulting in a         dimethylene amine:         NI-CH₂O—CH₂—NI+NH₃→NI-CH₂—NH—CH₂—NI+HOH         or         NI—CH₂O—CH₂—NI+NH₃→NI—CH₂NH₂+NI—CH₂OH         wherein NI is understood to mean Nitrification inhibitor.         In an embodiment, the molar percent of ammonia and/or ammonium         hydroxide charged is less than the molar percent of         methylol/ether functionalities present within structures of said         BPONIs. In a variation, the reaction product wherein the ratio         of moles of ammonia and/or ammonium hydroxide is less than the         moles of methylol functionalities and/or dimethylene ether         present within the structures of said BPONIs resulting in an         further increase in molecular weight of said BPONI.         In an embodiment, the molar percent of ammonia and/or ammonium         hydroxide charged is greater than the molar percent of         methylol/ether functionality present in the structures of said         BPONIs. In a variation, the reaction product wherein the ratio         of moles of ammonia and/or ammonium hydroxide is greater than         the moles of methylol/ether functionalities present within the         structures of said BPONIs resulting in aminating the BPONIS with         limited increase in molecular weight of said BPONIs.         In an embodiment, the method of use of the composition of said         BPONIs comprising methylene-bis-dicyandiamide, methylene         di-dicyandiamide, di-methylene tri-dicyandiamide, tri-methylene         tetra-dicyandiamide, reaction products of paraformaldehyde and         dicyandiamide, dicyandiamide and dimethyl sulfoxide and no         residual methylol/ether functionalities or unreacted         paraformaldehyde comprises a) application as a coating onto         fertilizer granules b) addition to anhydrous ammonia for direct         injection into the soil c) injection, spraying or metering into         molten urea d) spraying or metering onto hot nitrogen source         particles and injection, spraying or metering into hot molten         urea that is then sprayed or metered onto a urea particle         wherein there is no further reaction adducts formed between the         BPONI and the nitrogen sources. In another variation, addition         of said BPONIS that do not contain methylol and/or dimethylene         ether functionalities is added to a molten nitrogen source         and/or to a gaseous nitrogen source and/or to a liquid nitrogen         source without reacting with the nitrogen source resulting in no         chemical modifications of the nitrogen source's molecular         structure.         In an embodiment, inclusion of said BPONIs containing methylol         and dimethylene ether functionalities with nitrogen sources         increases the length of time for availability of nutrients from         nitrogen sources utilized for plant growth by imparting to         nitrogen sources the inhibition of the microbial conversion of         ammonia to nitrate and lower mobility through the soil by         decreasing the nitrogen sources' solubility in water.         In an embodiment, a method to make fertilizer compositions         comprised of a) liquid additives and b) nitrogen sources wherein         the one or more nitrogen sources are selected from the group         consisting of molten urea, molten urea/ammonia and ammonia and         the liquid additive comprises i) BPONIs containing methylol and         dimethylene ether functionalities and ii) NOSDS wherein said         BPONIs are dispersed into heated nitrogen sources wherein said         BPONI reacts with these nitrogen sources resulting in the         incorporation of nitrification inhibition with nitrogen sources.         In a variation, the fertilizer composition comprises weight         range of about 85-99.5%, 85-98%, 85-97%, 85-96%, 85-95%, 85-94%,         85-93%, 85-92%, 85-91%, 85-90%, 90-99.5%, and 95-99.5% of         nitrogen sources and weight ranges of about 15-0.5%, 15-1%,         15-2%, 15-3%, 15-4%, 15-5%, 15-6%, 15-7%, 15-8%, 15-9%, 15-10%,         10-0.5%, 7-0.5%, and 5-0.5% of liquid additive. In another         variation the composition of the liquid additive comprises         weight ranges of about 40-80%, 45-80%, 50-80%, 55-80%, 60-80%,         65-80%, 70-80%, 40-70%, 40-60%, 50-80%, 50-70%, 60-80%, 60-70%,         and 70-80% BPONIs and weight ranges of about 20-60%, 20-55%,         20-50%, 20-45%, 20-40%, 20-35%, 20-30%, 25-60%, 30-60%, 35-60%,         45-60%, 50-60% of a NOSDS. In another variation, the NOSDS is         the NAPAOL that is utilized as the reaction medium.         In another variation, NOSDS is added to said BPONI to impact one         or more properties of treated nitrogen sources selected from the         group consisting of a) water resistance/repellency, b) clumping         of solid nitrogen sources c) longer availability of nitrogen         within the soil for the life and growth of plants, d) coating         the surface of fertilizer granules/prills e) dispersing said         BPONIs into an aqueous nitrogen source such as UAN f) dispersing         the liquid invention into ammonical sub-surface injections, g)         homogeneity of the dispersion within liquid/molten nitrogen         sources and h) increasing nitrogen sources granules crush         strength.

In an embodiment, method to make a water resistant/repellent fertilizer granule compositions comprise

-   1) utilizing one or more granulation processes selected from the     group consisting of a) drum granulation process and b) fluid bed     granulation process, -   2) fertilizer composition comprised of BPONIs and nitrogen sources     wherein the BPONI is comprised of:     -   a) one or more structures selected from the group consisting of         -   i)

-   -   -   ii) and

-   -   -   -   wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are                 one or more members independently selected from the                 group consisting of: H and —CH₂OH and wherein x=2-20

    -   b) NOSDS comprised of one or more aprotic solvents and protic         solvents wherein the one or more aprotic solvents are selected         from the group consisting of:         -   i) dimethyl sulfoxide,         -   ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the             formula:             R₉S(O)_(x)R₁₀,             -   wherein R₉ and R₁₀ are each independently a C₁₋₆                 alkylene group, an aryl group, or C₁₋₃alkylenearyl group                 or R₉ and R₁₀ together with the sulfur to which they are                 attached form a 4 to 8 membered ring wherein R₉ and R₁₀                 together are a C₁₋₆ alkylene group which optionally                 contains one or more atoms selected from the group                 consisting of O, S, Se, Te, N, and P in the ring and x                 is 1 or 2,         -   iii) one or more alkylene carbonates selected from the group             consisting of ethylene carbonate, propylene carbonate and             butylene carbonate, iv) one or more alkyl pyrrolidones             selected from the group consisting of 1-Methyl-2-pyrrolidone             and butyl pyrrolidone, v) one or more organo phosphorous             liquids selected from the group consisting of             hexamethylphosphoramide and one or more trialkylphosphates             selected from the group represented by the formula:

-   -   -   -   wherein:                 -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃                 -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃                 -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

        -   vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether             and viii) cyclohexylpyrrolidone, and

    -   wherein the one or more protic solvents are selected from the         group consisting of: i) an alcohol from the family of C₁₋₁₀         alkanols, ii) one or more polyols from the group consisting of         trimethylol propane, trimethylol ethane, pentaerythritol,         sorbitol and sorbitan, glucose, fructose, galactose, and         glycerin, iii) poly(C₁₋₁₀ alkylene) glycols, iv) one or more         alkylene glycols from the group consisting of ethylene glycol,         1,3 propylene glycol, 1,2 propylene glycol, and butylene         glycol, v) isopropylidene glycerol vi) one or more alkylene         glycol alkyl ethers represented by the structure:

-   -   -   where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉         -   where R² is: H or

-   -   -   where R³ is: H or CH₃         -   where R⁴ is H and/or CH₃         -   and f is an integer between 1 and 15         -   vii) one or more alkyl lactates from the group consisting of             ethyl, propyl and butyl lactate, vii) one or more             alkanolamines represented by the structure:

-   -   -   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH             -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH             -   where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH             -   where R⁸ is: (C₂H₄O)_(g)H             -   and g is an integer between 1-10,

        -   and ix) glycerol carbonate,

    -   c) and wherein the one or more nitrogen sources are selected         from the group consisting of: i) urea, ii) ammonia, iii)         ammonium hydroxide, iv) urea formaldehyde reaction products, v)         urea, formaldehyde and ammonia reaction products, vi) ammonium         nitrate, vii) ammonium sulfate, viii) manure ix) monoammonium         phosphate x) diammonium phosphate and xi) compost, wherein the         nitrogen sources comprise less than 1% water.

-   3) one or more nitrogen sources granulation processes selected from     the group consisting of drum granulation process and fluidized bed     granulation process wherein     -   a) said BPONIs containing methylol and dimethylene ether         functionalities are charged and mixed into the molten nitrogen         sources wherein the BPONIs containing methylol and dimethylene         ether functionalities reacts with the molten nitrogen sources         forming BPONI-modified nitrogen sources,     -   b) the nitrogen sources and BPONI-modified nitrogen sources         mixture is pumped to the spraying nozzles wherein the mixture         continues to react,     -   c) the mixture is then sprayed onto a bed of small nitrogen         sources particles (nitrogen sources particle seed) coating these         small nitrogen sources particles with a thin layer of molten         nitrogen sources and BPONI-modified nitrogen sources,     -   d) forced air is passed over the nitrogen sources particles         removing heat and allowing the thin layer of molten nitrogen         sources/BPONI-modified nitrogen sources to solidify,     -   e) the process is repeated until the desired size of the         nitrogen sources particle is achieved wherein the nitrogen         sources/BPONI-modified nitrogen sources particles are cooled to         ambient temperature and packaged,

In a variation, the compositional percentages, based on parts by weight, of the NOSDS of the liquid additives for fertilizers is in the range of about 10%-60%, 30%-60%, 40%-60%, 30%-50%, 30-40%, 20-30%, 20-40%, 20-50% and 20-60%. In a variation, low NOSDS results in nitrogen sources granules with good physical properties necessary for efficient and economical distribution of the nitrogen sources over wide areas.

In another variation, the degree water resistance/repellency can be varied by the percentage based on parts by weight of BPONI is of the fertilizer composition and by the molecular weight of the aldehyde-nitrification inhibitors adducts. In another variation, the percentage based on parts by weight of aldehyde-nitrification inhibitors adducts can be increased in the last few spray applications to insure a more hydrophobic final coating.

In another embodiment, a method to make fertilizer compositions comprising adding BPONI at elevated temperatures to molten nitrogen sources to lower said BPONI to lower viscosity and aide in ensuring a homogeneous distribution within the molten nitrogen source wherein the temperature ranges or the BPONI is about 80-140° C., 90-140° C., 90-130° C., 90-120° C., 90-110° C., 90-100° C., 100-140° C., 110-140° C., 120-140° C., or 130-140° C. In a variation, said BPONI can contain methylol and dimethylene ether functionalities within their structures which react with said nitrogen sources.

In another variation, said non-aqueous organo liquid solvents can be added to impact the properties of the treated nitrogen source such as but not limited to water resistance, clumping of solid nitrogen sources and homogeneity of the dispersion within liquid/molten nitrogen sources. In an embodiment, the composition of the BPONI can further comprise one or more members selected from the group consisting of:

-   -   1) a colorant that does not contain water and/or an alcohol may         be used to improve the visual evidence of complete coverage and         serve as a visual marker;     -   2) scents or masking agents to improve the odor of the         formulations;     -   3) Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   4) Buffering agents.     -   5) Catalyst(s) to improve reaction completion

In an embodiment, the liquid fertilizer composition can added to molten urea and/or ammonia resulting in an in situ modification of urea within the urea manufacturing process and/or an in situ modification of ammonia and wherein the NAPAOL would have urea solubilizing properties ensuring a more homogeneous distribution of nitrification inhibitors within the urea.

In another variation, the polymeric/oligomeric nitrification inhibitors comprise dicyandiamide wherein when added to a molten nitrogen source can form hydrophobic DCD blocks creating zones of water resistance within the resulting urea particle,

In an embodiment, the nitrogen source particles formed from the urea and/or urea-ammonia molten liquid containing the in situ reaction of the urea and urea/ammonia with the liquid additives for fertilizers comprised of:

-   -   1) an aprotic NOSDS wherein one or more of the aprotic solvents         contained in the NOSDS is the reaction medium for aldehydes         reaction with nitrification inhibitors,     -   2) one or more aldehydes selected from the group consisting of         formaldehyde, paraformaldehyde and 1,3,5-trioxane,     -   3) one or more nitrification inhibitors selected from the group         consisting of 2-chloro-6-trichloromethyl)pyridine,         4-amino-1,2,4-6-triazole-HCl,         2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide         (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium         thiosulfate, dimethylpyrazole and/or its organic and inorganic         salts and 2-amino-4-chloro-6-methylpyrimidine,     -   4) one or more dicyandiamide-formaldehyde adducts selected from         the group consisting of the following structures:         -   i)

-   -   -   -   wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members                 independently selected from the group consisting of: H                 and CH₂OH with the proviso that at least one of R₄₃ and                 R₄₄, R₄₅ and R₄₆ is a CH₂OH,

        -   ii)

-   -   -   iii)

-   -   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more                 members independently selected from the group consisting                 of: H, and —CH₂OH

        -   iv)

-   -   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are                 one or more members independently selected from the                 group consisting of: H and —CH₂OH

        -   v)

-   -   -   -   wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are                 one or more members independently selected from the                 group consisting of: H and —CH₂OH and x=2-20

        -   vi)

-   -   -   wherein the aprotic NOSDS comprises one or more members             selected from the group consisting of:

    -   i) dimethyl sulfoxide,

    -   ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,

    -   iii) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, iv) one or more alkyl pyrrolidones selected         from the group consisting of 1-Methyl-2-pyrrolidone and butyl         pyrrolidone, v) one or more organo phosphorous liquids selected         from the group consisting of hexamethylphosphoramide and one or         more trialkylphosphates selected from the group represented by         the formula:

-   -   -   wherein:             -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether and viii)         cyclohexylpyrrolidone,

    -   wherein the said BPONI can added to molten urea and/or ammonia         resulting in an in situ modification of urea and/or ammonia         within the urea manufacturing process and wherein the NOSDS         would have urea solubilizing properties ensuring a more         homogeneous distribution of biodegradable polymeric and/or         oligomeric nitrification inhibitors within the urea.

In an embodiment, the composition of the BPONI can further comprise one or more members selected from the group consisting of:

-   -   1) a food coloring or dye that may be used to improve the visual         evidence of complete coverage and serve as a visual marker;     -   2) scents or masking agents to improve the odor of the         formulations;     -   3) Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   4) Buffering agents.     -   5) Catalyst(s) to improve reaction completion

In an embodiment, the NOSDS and/or the NAPAOL are dimethyl sulfoxide.

In an embodiment, it is beneficial for urea and/or ammonia to have good solubility in the delivery vehicle, NOSDS. In a variation, the liquid additives for fertilizers are added to anhydrous ammonia, a molten pool of urea and/or a molten pool of urea that is either in an ammonia atmosphere, has ammonia dissolved within the molten pool or that has ammonia added before, during or after the charge of the liquid fertilizer additive.

In an embodiment, the composition of the BPONIs further comprise one or more alkoxy capped monomers selected from the group consisting of 1,3,4,6-tetrakis(methoxymethyl)glycoluril, N,N,N′,N′,N″,N″-hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triamine, tetra(methoxymethyl) urea and di(methoxymethyl) urea to increase crosslinking of compounds containing aldehyde reactive groups and reaction with the nitrogen sources. In a variation, if the application technique is the addition of the BPONIs to a liquid/molten nitrogen source, the usage rate will be dependent on the desired solubility and impact of the desired granule/prill properties.

In an embodiment, the method to make a fertilizer composition comprised of:

-   -   1) one or more nitrogen sources selected from the group         consisting of: i) urea, ii) ammonia, iii) ammonium         hydroxide, iv) urea formaldehyde reaction products, v) urea,         formaldehyde and ammonia reaction products, vi) ammonium         nitrate, vii) ammonium sulfate, viii) manure ix) monoammonium         phosphate x) diammonium phosphate and xi) compost,     -   2) NOSDS wherein the NOSDS is comprised partially or completely         of a NAPAOL,     -   3) one or more BPONIs selected from the group consisting of         -   i) BPONI that contain methylol and/or dimethylene ether             functionalities that reacts with nitrogen sources and,         -   ii) BPONI that do not contain methylol and/or dimethylene             ether functionalities and therefore have no further             reactions with nitrogen sources,             comprises the addition of BPONIs that optionally can contain             methylol and/or dimethylene ether functionalities to             nitrogen sources at or heated to elevated temperatures in             the range of about 80-140° C., 90-140° C., 90-130° C.,             90-120° C., 90-110° C., 90-100° C., 100-140° C., 110-140°             C., 120-140° C., or 130-140° C.

In an embodiment, a method to make liquid additive compositions for fertilizers comprised of a) biodegradable polymeric and/or oligomeric nitrification inhibitors and b) a NOSDS wherein the NOSDS is a NAPAOL which is utilized as the reaction medium for the reaction of one or more aldehyde(s) with one or more cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols wherein said liquid additives for fertilizers comprised of biodegradable polymeric and/or oligomeric nitrification inhibitors which contains no methylol functionalities and/or no dimethylene ether functionalities comprise: a) dissolve said nitrification inhibitors in a NAPAOL at temperatures in the range of about 30-110° C., 40-100° C., 40-90° C., 40-80° C., 40-70° C., 50-70° C., 60-70° C., 50-80° C., 50-90° C., 60-90° C., and 70-90° C., b) optional cool to 40-60° C., c) adjust pH, if necessary, to the range of about 7.5-11, 8.0-10.5, 8.5-10.5, 9.0-11, 9.5-11, 10-11, 9.0-10.0, 9.5-10.5, 8.5-10, and 8.5-10,d) slowly add the aldehyde and allow the exothermic to be controlled either through charge rate or removing the heat of reaction through a cooling median, e) slowly heat the composition to a temperature range of about 60-90° C., 70-90° C., 75-90° C., 80-90° C., 70-80° C., 60-80° C., and 60-70° C., f) hold at temperature for about 0.5-1 hours, 1-2 hours, 1-3 hours, 2-3 hours, 3-4 hours, 4-5 hours, 4-6 hours, 4-7 hours, 4-8 hours, 4-9 hours, 5-6 hours, 5-7 hours, and 6-7 hours, g) optionally, cool the composition to 40-70° C., h) adjust pH to about 9.5-11.5, 9.5-11.0, 9.5-10.5, 9.5-10.0, 10-11.5, and 10.5-11.5 by slowly adding one or more alkalis selected from the group consisting of i) elemental metals ii) metal oxides iii) metal hydroxides, iv) metal alkylates and v) metal carbonates wherein the cation of the alkalis comprise one or more metals selected from the group consisting of Na, K, Mg, and Ca i) react composition a temperature range 80-90° C., 70-90° C., 70-80° C., 80-100° C., 80-110° C., 80-120° C., 90-120° C., 90-110° C., 90-100° C., 100-120° C., and 110-120° C., j) hold at temperature for about 0.5-1 hours, 1-2 hours, 1-3 hours, 2-3 hours, 3-4 hours, 4-5 hours, 4-6 hours, 4-7 hours, 4-8 hours, 4-9 hours, 5-6 hours, 5-7 hours, and 6-7 hours, and optionally, one can elect to place the batch under a vacuum to assist in removing water by-products, driving the reaction to more completion and removing any unreacted aldehyde and then cooling the batch. In a variation, the pH is adjusted after completion of the reaction to 7.0-10.0 with organic and/or inorganic acids, or neutralized polycarboxylic acids and/or imides.

In an embodiment, fertilizer compositions comprise a) one or more nitrogen sources and b) one or more biodegradable polymeric and/or oligomeric nitrification inhibitors.

In an embodiment, fertilizer compositions comprises a) one or more nitrogen sources, b) one or more biodegradable polymeric and/or oligomeric nitrification inhibitors and c) one or more reaction products of biodegradable polymeric and/or oligomeric nitrification inhibitors with methylol and/or dimethylene ether functionalities and one or more nitrogen sources.

In an embodiment, fertilizer compositions comprising a) one or more nitrogen sources selected from the group consisting of i) urea, ii) ammonia, iii) ammonium hydroxide, iv) urea formaldehyde reaction products, v) urea, formaldehyde and ammonia reaction products, vi) ammonium nitrate, vii) ammonium sulfate, viii) manure ix) monoammonium phosphate x) diammonium phosphate and xi) compost, b) one or more formaldehyde-dicyandiamide adducts selected from the structures consisting of:

-   -   i)

-   -   -   wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members             independently selected from the group consisting of: H and             CH₂OH with the proviso that at least one of R₄₃ and R₄₄, R₄₅             and R₄₆ is a CH₂OH,

    -   ii)

-   -   iii)

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂OH

    -   iv)

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂OH

    -   v)

-   -   -   wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂OH and x=2-20

    -   vi)

In a variation, fertilizer compositions further comprise a) unreacted dicyandiamide and b) one or more reaction products of biodegradable polymeric and/or oligomeric nitrification inhibitors with methylol and/or dimethylene ether functionalities and one or more nitrogen sources.

In another variation, fertilizer composition further comprise a NOSDS wherein the NOSDS comprises a) a NAPAOL and one or more solvents selected from the group consisting a) an aprotic NOSDS and b) a protic NOSDS

wherein the NAPAOL comprises one or more member selected from the group consisting of:

-   -   i) dimethyl sulfoxide,     -   ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,     -   iii) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate         wherein the aprotic NOSDS comprises one or more members selected         from the group consisting of     -   i) dimethyl sulfoxide,     -   ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,     -   iii) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, iv) one or more alkyl pyrrolidones selected         from the group consisting of 1-Methyl-2-pyrrolidone and butyl         pyrrolidone, v) one or more organo phosphorous liquids selected         from the group consisting of hexamethylphosphoramide and one or         more trialkylphosphates selected from the group represented by         the formula:

-   -   -   wherein:             -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether and viii)         cyclohexylpyrrolidone,

    -   wherein the one or more protic solvents are selected from the         group consisting of: i) an alcohol from the family of C₁₋₁₀         alkanols, ii) one or more polyols from the group consisting of         trimethylol propane, trimethylol ethane, pentaerythritol,         sorbitol and sorbitan, glucose, fructose, galactose, and         glycerin, iii) poly(C₁₋₁₀ alkylene) glycols, iv) one or more         alkylene glycols from the group consisting of ethylene glycol,         1,3 propylene glycol, 1,2 propylene glycol, and butylene         glycol, v) isopropylidene glycerol vi) one or more alkylene         glycol alkyl ethers represented by the structure:

-   -   -   where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉

-   -   -   where R² is: H or         -   where R³ is: H or CH₃         -   where R⁴ is H and/or CH₃         -   and f is an integer between 1 and 15

    -   vii) one or more alkyl lactates from the group consisting of         ethyl, propyl and butyl lactate, vii) one or more alkanolamines         represented by the structure:

-   -   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH         -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁸ is: (C₂H₄O)_(g)H         -   and g is an integer between 1-10,

    -   and ix) glycerol carbonate,

In an embodiment, fertilizer compositions comprise a) urea and b) one or more formaldehyde-dicyandiamide adducts selected from the structures consisting of:

-   -   i) one or more structures

-   -   -   wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members             independently selected from the group consisting of: H and             —CH₂—NH—CO—NH₂ with the proviso that at least one of R₄₃ and             R₄₄, R₄₅ and R₄₆ is —CH₂—NH—CO—NH₂,

    -   ii) one or more of the structures:

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂—NH—CO—NH₂

    -   iii) one or more of the structures

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂—NH—CO—NH₂

    -   iv) one or more of the structures

-   -   -   wherein R₆₁ R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂—NH—CO—NH₂ and x=2-20             wherein the urea is a temperature ranges of 80-140° C.,             90-140° C., 90-130° C., 90-120° C., 90-110° C., 90-100° C.,             100-140° C., 110-140° C., 120-140° C., or 130-140° C.,             wherein a portion of the one or more             formaldehyde-dicyandiamide adducts optionally contained no             methylol and/or dimethylene ether functionalities and             wherein a portion of the one or more             formaldehyde-dicyandiamide adducts optionally contain             methylol and/or dimethylene ether functionalities that have             reacted with urea.

In a variation, fertilizer compositions further comprise unreacted dicyandiamide, said NAPAOL and optionally said aprotic NOSDS and said protic NOSDS

In an embodiment, fertilizer compositions comprise a) liquid ammonia and b) one or more formaldehyde-dicyandiamide adducts selected from the structures consisting of:

-   -   i) one or more structures

-   -   -   wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members             independently selected from the group consisting of: H and             —CH₂—NH—CO—NH₂ with the proviso that at least one of R₄₃ and             R₄₄, R₄₅ and R₄₆ is —CH₂NH₂,

    -   ii) one or more of the structures:

-   -   -   wherein R₄₇ R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂NH₂

    -   iii) one or more of the structures

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂NH₂

    -   iv) one or more of the structures

-   -   -   wherein R₆₁ R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂NH₂ and x=2-20             wherein the ammonia gas is sparged through the one or more             formaldehyde-dicyandiamide adducts at a temperature ranges             of 25-120° C., 30-100° C., 40-100° C., 50-100° C., 60-100°             C., 70-100° C., 90-100° C., 60-90° C., 70-90° C., 80-90° C.,             60-80° C., 70-80° C., or 70-120° C., wherein a portion of             the one or more formaldehyde-dicyandiamide adducts             optionally contained no methylol and/or dimethylene ether             functionalities and wherein a portion of the one or more             formaldehyde-dicyandiamide adducts optionally contain             methylol and/or dimethylene ether functionalities that have             reacted with NH₃.

In a variation, fertilizer compositions further comprise unreacted dicyandiamide, said NAPAOL and optionally said aprotic NOSDS and said protic NOSDS.

In an embodiment, inclusion of said BPONIs, optionally containing methylol and dimethylene ether functionalities and optionally containing the reaction products of the nitrogen sources and the BPONIs methylol and dimethylene ether functionalities with nitrogen sources increases the length of time for the availability of nitrogen to plants. The application of BPONI treated nitrogen sources to plant growth mediums imparts the inhibition of the microbial conversion of ammonia to nitrate and lowers mobility of nutrients through the plant growth medium by decreasing the nitrogen sources' and nitrification inhibitors' solubility in water.

In an embodiment, a method of making fertilizer compositions wherein the fertilizer composition comprises a) urea and b) one or more biodegradable polymeric and/or oligomeric nitrification inhibitors (BPONI) selected from the structures consisting of:

-   -   v) one or more structures

-   -   -   wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members             independently selected from the group consisting of: H and             —NH—CO—NH₂ with the proviso that at least one of R₄₃ and             R₄₄, R₄₅ and R₄₆ is —NH—CO—NH₂,

    -   vi) one or more of the structures:

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —NH—CO—NH₂

    -   vii) one or more of the structures

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —NH—CO—NH₂

    -   viii) one or more of the structures

-   -   -   wherein R₆₁ R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —NH—CO—NH₂ and x=2-20         -   wherein the urea is at a temperature ranges of 80-140° C.,             90-140° C., 90-130° C., 90-120° C., 90-110° C., 90-100° C.,             100-140° C., 110-140° C., 120-140° C., or 130-140° C.,             wherein a portion of the one or more BPONI optionally             contained no methylol and/or dimethylene ether             functionalities and wherein a portion of the one or more             BPONI optionally contain methylol and/or dimethylene ether             functionalities that have reacted with urea.

In an embodiment, a method of making fertilizer compositions wherein the fertilizer composition further comprise a) unreacted dicyandiamide and b) a NOSDS wherein the NOSDS comprises a) a NAPAOL and one or more solvents selected from the group consisting a) an aprotic NOSDS and b) a protic NOSDS

-   -   wherein the NAPAOL comprises one or more member selected from         the group consisting of:     -   iv) dimethyl sulfoxide,     -   v) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,     -   vi) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate     -   wherein the aprotic NOSDS comprises one or more members selected         from the group consisting of:     -   iv) dimethyl sulfoxide,     -   v) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,     -   vi) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, iv) one or more alkyl pyrrolidones selected         from the group consisting of 1-Methyl-2-pyrrolidone and butyl         pyrrolidone, v) one or more organo phosphorous liquids selected         from the group consisting of hexamethylphosphoramide and one or         more trialkylphosphates selected from the group represented by         the formula:

-   -   -   wherein:             -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether and viii)         cyclohexylpyrrolidone, wherein the one or more protic solvents         are selected from the group consisting of: i) an alcohol from         the family of C₁₋₁₀ alkanols, ii) one or more polyols from the         group consisting of trimethylol propane, trimethylol ethane,         pentaerythritol, sorbitol and sorbitan, glucose, fructose,         galactose, and glycerin, iii) poly(C₁₋₁₀ alkylene) glycols, iv)         one or more alkylene glycols from the group consisting of         ethylene glycol, 1,3 propylene glycol, 1,2 propylene glycol, and         butylene glycol, v) isopropylidene glycerol vi) one or more         alkylene glycol alkyl ethers represented by the structure:

-   -   -   where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉

-   -   -   where R² is: H or         -   where R³ is: H or CH₃         -   where R⁴ is H and/or CH₃         -   and f is an integer between 1 and 15

    -   vii) one or more alkyl lactates from the group consisting of         ethyl, propyl and butyl lactate,

    -   viii) one or more alkanolamines represented by the structure:

-   -   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH         -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where IV is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁸ is: (C₂H₄O)_(g)H         -   and g is an integer between 1-10, and

    -   ix) glycerol carbonate.

In a variation, a method of making fertilizer compositions wherein the fertilizer composition further comprises one or more members selected from the group consisting of:

-   -   a. a colorant that does not contain water and/or an alcohol may         be used to improve the visual evidence of complete coverage and         serve as a visual marker;     -   b. scents or masking agents to improve the odor of the         formulations;     -   c. Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   d. Buffering agents.     -   e. Catalyst(s) to improve reaction completion

In an embodiment, a method of making fertilizer composition comprises that the urea is chemically modified in its molten state by the addition of BPONI containing one or more functionalities selected from the group consisting of methylol and dimethylene ether functionalities wherein the chemically modified urea particles formation comprise one or more processes selected from the group consisting of a) urea rotating drum granulation, b) urea fluidized bed granulation and c) urea prilling tower comprises process.

In an embodiment, a method of making fertilizer compositions utilizes the urea rotating drum granulation process comprised of one or more steps selected from the group consisting of

-   -   a. formaldehyde-dicyandiamide containing methylol and         dimethylene ether functionalities are charged and mixed into the         molten urea wherein the BPONI containing methylol and         dimethylene ether functionalities reacts with the molten urea         forming BPONI-modified urea,     -   b. the urea and the BPONI-modified urea mixture is pumped to the         spraying nozzles wherein the mixture continues to react,     -   c. the mixture is then sprayed onto a bed of small urea         particles (urea particle seed) inside a rotating drum coating         these small urea particles with a thin layer of molten urea and         BPONI-modified urea,     -   d. forced air is passed over the nitrogen sources particles         removing heat and allowing the thin layer of molten         urea/BPONI-modified urea to solidify,     -   e. the process is repeated until the desired size of the urea         particle is achieved wherein the urea/BPONI-modified urea         particles are cooled to ambient temperature and packaged.

A variation, the making of a fertilizer composition utilizes the urea fluidized bed granulation process comprised of one or more steps selected from the group consisting of

-   -   a. formaldehyde-dicyandiamide containing methylol and         dimethylene ether functionalities are charged and mixed into the         molten urea wherein the BPONI containing methylol and         dimethylene ether functionalities reacts with the molten urea         forming BPONI-modified urea,     -   b. the urea and the BPONI-modified urea mixture is pumped to the         spraying nozzles wherein the mixture continues to react,     -   c. the mixture is then sprayed onto a bed of small urea         particles (urea particle seed) inside a fluid bed granulator         coating these small urea particles with a thin layer of molten         urea and BPONI-modified urea,     -   d. the rotating or rolling of the small urea particles is         accomplished by the use of large volumes of air blown up through         a bed of small urea particles removing heat and allowing the         thin layer of molten urea/BPONI-modified urea to solidify,     -   e. the process is repeated until the desired size of the urea         particle is achieved wherein the urea/BPONI-modified urea         particles are cooled to ambient temperature and packaged.

A variation, the making of a fertilizer composition utilizes the urea prilling process comprised one or more steps selected from the group consisting of

-   -   a. formaldehyde-dicyandiamide containing methylol and         dimethylene ether functionalities are charged and mixed into the         molten urea wherein the BPONI containing methylol and         dimethylene ether functionalities reacts with the molten urea         forming BPONI-modified urea,     -   b. the urea and the BPONI-modified urea mixture is pumped to         shower generating heads at the top of the prilling tower wherein         the mixture continues to react,     -   c. droplets of the molten urea and BPONI-modified urea mixture         forms as it passes through the shower head into the tower     -   d. counter current air flows up the tower cooling the droplets         below the freezing point and thus form small, round, solid         pellets called prills. The urea and BPONI-modified urea prills         are then cooled and then packaged.

In a variation, a method of making a fertilizer composition wherein the composition further comprises one or more member selected from the group consisting of a) unreacted DCD, b) formaldehyde-DCD adduct that do not contain methylol and/or dimethylene ether functionalities c) a NAPAOL and d) one or more members selected from the group consisting of:

-   -   i. a colorant that does not contain water and/or an alcohol may         be used to improve the visual evidence of complete coverage and         serve as a visual marker;     -   ii. scents or masking agents to improve the odor of the         formulations;     -   iii. Nonionic, anionic, cationic, zwitterionic, and/or         amphoteric surfactants to improve formula application         performance of fertilizer granules; and     -   iv. Buffering agents.     -   v. Catalyst(s) to improve reaction completion

In an embodiment, a method of making fertilizer compositions wherein the fertilizer composition is comprised of a) urea and b) one or more BPONI with no methylol and/or dimethylene ethers, c) one or more BPONI with methylol and/or dimethylene ethers and d) a NAPAOL as the reaction medium wherein the urea is at a temperature ranges of 80-140° C., 90-140° C., 90-130° C., 90-120° C., 90-110° C., 90-100° C., 100-140° C., 110-140° C., 120-140° C., or 130-140° C., and is contacted by the one or more BPONI containing methylol and/or dimethylene ether functionalities and wherein the urea and the BPONI containing methylol and/or dimethylene ether functionalities have solubility in the NAPAOL wherein the NAPOAL is the reaction medium for the urea and the BPONI containing methylol and/or dimethylene ether functionalities resulting in one or more BPONI-modified ureas,

In a variation the compositional weight ratios BPONIs to NAPAOL is in the ranges of about 40-80%, 45-80%, 50-80%, 55-80%, 60-80%, 65-80%, 70-80%, 40-70%, 40-60%, 50-80%, 50-70%, 60-80%, 60-70%, and 70-80% of BPONIs and to about 20-60%, 20-55%, 20-50%, 20-45%, 20-40%, 20-35%, 20-30%, 25-60%, 30-60%, 35-60%, 45-60%, 50-60% of a NAPAOL, and wherein the compositional weight ratios of BPONIs and NAPAOL to urea is in the ranges of about 15-0.5%, 15-1%, 15-2%, 15-3%, 15-4%, 15-5%, 15-6%, 15-7%, 15-8%, 15-9%, 15-10%, 10-0.5%, 7-0.5%, and 5-0.5% of BONIs and NAPAOL and about 85-99.5%, 85-98%, 85-97%, 85-96%, 85-95%, 85-94%, 85-93%, 85-92%, 85-91%, 85-90%, 90-99.5%, and 95-99.5% of urea.

In an embodiment, a method of making a fertilizer composition wherein the NAPAOL comprises one or more member selected from the group consisting of:

-   -   a. dimethyl sulfoxide,     -   b. dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,     -   c. one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate.

In an embodiment, a method to make a fertilizer composition, wherein the fertilizer compositions comprise one or more BPONI-modified urea selected from the structures consisting of:

-   -   ix) one or more structures

-   -   -   wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members             independently selected from the group consisting of: H and             —CH₂—NH—CO—NH₂ with the proviso that at least one of R₄₃ and             R₄₄, R₄₅ and R₄₆ is —CH₂—NH—CO—NH₂,

    -   x) one or more of the structures:

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂—NH—CO—NH₂

    -   xi) one or more of the structures

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂—NH—CO—NH₂

    -   xii) one or more of the structures

-   -   -   wherein R₆₁ R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂—NH—CO—NH₂ and x =2-20

In an embodiment, a method to make fertilizer compositions, wherein the fertilizer compositions further comprise one or more nitrogen sources selected from the group consisting of i) ammonia, ii) ammonium hydroxide, iii) urea formaldehyde reaction products, iv) urea, formaldehyde and ammonia reaction products, v) ammonium nitrate, vi) ammonium sulfate, vii) manure viii) monoammonium phosphate ix) diammonium phosphate and x) compost.

In an embodiment, a method to make fertilizer composition, wherein the fertilizer compositions further comprise a) unreacted dicyandiamide b) an aprotic NOSDS, c) a protic NOSDS d) one or more members selected from the group consisting of:

-   -   f. a colorant that does not contain water and/or an alcohol may         be used to improve the visual evidence of complete coverage and         serve as a visual marker;     -   g. scents or masking agents to improve the odor of the         formulations;     -   h. Nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules; and     -   i. Buffering agents.     -   j. Catalyst(s) to improve reaction completion

In a variation, a method to make a fertilizer composition, wherein the aprotic NOSDS comprises one or more solvents selected from the group consisting of

-   -   i. dimethyl sulfoxide,     -   ii. dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,         -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene             group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and             R₁₀ together with the sulfur to which they are attached form             a 4 to 8 membered ring wherein R₉ and R₁₀ together are a             C₁₋₆ alkylene group which optionally contains one or more             atoms selected from the group consisting of O, S, Se, Te, N,             and P in the ring and x is 1 or 2,     -   iii. one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, iv) one or more alkyl pyrrolidones selected         from the group consisting of 1-Methyl-2-pyrrolidone and butyl         pyrrolidone, v) one or more organo phosphorous liquids selected         from the group consisting of hexamethylphosphoramide and one or         more trialkylphosphates selected from the group represented by         the formula:

-   -   wherein:         -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃         -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃         -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃     -   vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether and viii)         cyclohexylpyrrolidone.

In a variation, a method to make a fertilizer composition, wherein the protic NOSDS comprises one or more solvents selected from the group consisting of i) an alcohol from the family of C₁-10 alkanols, ii) one or more polyols from the group consisting of trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol and sorbitan, glucose, fructose, galactose, and glycerin, iii) poly(C₁₋₁₀ alkylene) glycols, iv) one or more alkylene glycols from the group consisting of ethylene glycol, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, v) isopropylidene glycerol vi) one or more alkylene glycol alkyl ethers represented by the structure:

-   -   where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉

-   -   where R² is: H or     -   where R³ is: H or CH₃     -   where R⁴ is H and/or CH₃     -   and f is an integer between 1 and 15     -   vii) one or more alkyl lactates from the group consisting of         ethyl, propyl and butyl lactate,     -   viii) one or more alkanolamines represented by the structure:

-   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH     -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH     -   where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH     -   where R⁸ is: (C₂H₄O)_(g)H     -   and g is an integer between 1-10, and     -   xiii) glycerol carbonate.

In an embodiment a method of making fertilizer compositions, wherein the urea is chemically modified in its molten state by the addition of BPONI containing one or more functionalities selected from the group consisting of methylol and dimethylene ether functionalities wherein NAPAOL is the reaction medium for the chemically modification of the urea in the urea particles formation comprising one or more processes selected from the group consisting of a) urea rotating drum granulation, b) urea fluidized bed granulation and c) urea prilling tower comprises process.

In an embodiment, a method of making fertilizer compositions utilizing the urea rotating drum granulation process comprises one or more steps selected from the group consisting of

-   -   f. formaldehyde-dicyandiamide containing methylol and         dimethylene ether functionalities and NAPAOL are charged and         mixed into the molten urea wherein the BPONI containing methylol         and dimethylene ether functionalities reacts with the molten         urea forming BPONI-modified urea,     -   g. the urea, NAPAOL and the BPONI-modified urea mixture is         pumped to the spraying nozzles wherein the mixture continues to         react,     -   h. the mixture is then sprayed onto a bed of small urea         particles (urea particle seed) inside a rotating drum coating         these small urea particles with a thin layer of molten urea,         NAPAOL and BPONI-modified urea,     -   i. forced air is passed over the nitrogen sources particles         removing heat and allowing the thin layer of molten         urea/BPONI-modified urea to solidify,     -   j. the process is repeated until the desired size of the urea         particle is achieved wherein the urea/BPONI-modified urea         particles are cooled to ambient temperature and packaged.

In a variation, a method of making fertilizer compositions utilizing the urea fluidized bed granulation process comprises one or more steps selected from the group consisting of

-   -   f. formaldehyde-dicyandiamide containing methylol and         dimethylene ether functionalities and NAPAOL are charged and         mixed into the molten urea wherein the BPONI containing methylol         and dimethylene ether functionalities reacts with the molten         urea forming BPONI-modified urea utilizing the NAPAOL as the         reaction medium,     -   g. the urea, NAPAOL and the BPONI-modified urea mixture is         pumped to the spraying nozzles wherein the mixture continues to         react,     -   h. the mixture is then sprayed onto a bed of small urea         particles (urea particle seed) inside a fluid bed granulator         coating these small urea particles with a thin layer of molten         urea, NAPAOL and BPONI-modified urea,     -   i. the rotating or rolling of the small urea particles is         accomplished by the use of large volumes of air blown up through         a bed of small urea particles removing heat and allowing the         thin layer of molten urea/BPONI-modified urea to solidify,     -   j. the process is repeated until the desired size of the urea         particle is achieved wherein the urea/BPONI-modified urea         particles are cooled to ambient temperature and packaged.

In an embodiment, a method of making fertilizer compositions utilizing the urea prilling process comprises one or more steps selected from the group consisting of

-   -   e. formaldehyde-dicyandiamide containing methylol and         dimethylene ether functionalities and NAPAOL are charged and         mixed into the molten urea wherein the BPONI containing methylol         and dimethylene ether functionalities reacts with the molten         urea forming BPONI-modified urea utilizing the NAPAOL as the         reaction medium,     -   f. the urea, NAPAOL and the BPONI-modified urea mixture is         pumped to shower generating heads at the top of the prilling         tower wherein the mixture continues to react,     -   g. droplets of the molten urea, NAPAOL and BPONI-modified urea         mixture forms as it passes through the shower head into the         tower.     -   h. counter current air flows up the tower cooling the droplets         below the freezing point and thus form small, round, solid         pellets called prills. The urea and BPONI-modified urea prills         are then cooled and then packaged.

In a variation, a method of making fertilizer compositions, wherein the composition further comprises one or more member selected from the group consisting of a) unreacted DCD, b) formaldehyde-DCD adduct that do not contain methylol and/or dimethylene ether functionalities.

EXAMPLES Example 1

157.43 grams of dicyandiamide is added to 299.4 grams of dimethyl sulfoxide, heated under agitation to 60° C. and held at 60° C. until mixture is clear. The mixture is cooled to 40-45° C. and then 42.17 grams of paraformaldehyde is slowly charged. The batch is held at 45-55° C. for 1.5 hours. The batch is then heated to 60° C. over a one hour period. After 1 hour, 1.0 grams of methane sulfonic acid/70% is charged and batch is slowly heated to 100° C. over a 3 hour period. A vacuum of 40 mm is applied for 30 minutes until distillation ceased, then batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 2

274.12 grams of dicyandiamide is added to 403.03 grams of dimethyl sulfoxide, heated under agitation to 60° C. and held at 60° C. until mixture is clear. 97.91 grams of paraformaldehyde is slowly charged. The batch is held at 60° C. for 9 hours until batch is somewhat clear. The batch is then heated to 80° C. over a one hour period. After 1 hour, 3.72 grams of methane sulfonic acid/70% is charged and batch is slowly heated to 100° C. over a 1.5 hour period. The batch is heated to 110° C. and a vacuum of 135-140 mm is pulled for a 15 minute period. The batch is then heated to 120° C., a vacuum of 135-140 mm is applied for 35 minutes until distillation ceased, then batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 3

117.6 grams of dicyandiamide is added to 99.4 grams of dimethyl sulfoxide and heated under agitation to 85° C. over a 45 minute period. 31.5 grams of paraformaldehyde is charged and then 1.49 grams of methane sulfonic acid/70% is charged. The batch is slowly heated to 150° C. over a 3.5 hour period. The batch is heated to 110° C. and a vacuum of 135-140 mm is pulled for a 15 minute period. The batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 4

111.8 grams of cicyandiamide is added to 98.49 grams of dimethyl sulfoxide, heated under agitation to 80° C., held at 80C for 1 hr, then heated to 90° C. and held for 30 minutes. 1.24 grams of KOH (flake) is charged, then 35.94 grams of paraformaldehyde is slowly charged, then batch is cooled to 60-70° C. and held for 17 hours. The batch is then heated to 100° C. over a 2 hour period. 10.08 grams of methane sulfonic acid/70% is charged and batch is slowly heated to 100° C. over a 1.5 hour. The batch is heated to 150° C. over a 3 hour period. The batch is then cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 5

42.48 grams of dicyandiamide is added to 54.26 grams of dimethyl sulfoxide and heated under agitation to 80° C. min a 1.5 hour period. The batch is cooled to 40° C., 2.0 grams of paraformaldehyde is charged, the batch is slowly heated to 80° C. over a 1 hour period and then 0.6 gram of methane sulfonic acid/70% is charged. The batch is heated to 90° C. over a 2.25 hour period and 48.8 grams ethylene glycol is added. The batch is cooled to <60° C. and off-loaded. Product is turbid with particles and viscous.

Example 6

47.05 grams of dicyandiamide is added to 50.13 grams of dimethyl sulfoxide and heated under agitation to 80° C. min a 1.25 hour period. The batch is cooled to 44° C., 2.22 grams of paraformaldehyde is charged and the batch is slowly heated to 70° C. over a 1 hour period. The batch is heated to 140° C. over a 2.5 hour period. The batch is cooled to <60° C. and off-loaded. Product is turbid with particles and viscous.

Example 7

31.63 grams of dicyandiamide is added to 33.7 grams of dimethyl sulfoxide and heated under agitation to 80° C. min a 0.5 hour period. The batch is cooled to 45° C., 2.0 grams of paraformaldehyde is charged and the batch is slowly heated to 70° C. over a 1 hour period. The batch is held at 70° C. for 1 hour, then 0.4 grams methane sulfonic acid/70% is charged, mixed at 70° C. for one hour and then the batch is heated to 90° C. over a 2 hour period. A vacuum of 29 mm is pulled on the reactor for 20 minutes, the vacuum is broken, 59.48 grams of ethylene glycol are charged and mixed for 1 hour. The batch is cooled to <60° C. and off-loaded. Product is turbid with particles and viscous.

Example 8

67.0 grams of dicyandiamide is added to 67.4 grams of dimethyl sulfoxide and heated under agitation to a minimum of 90° C. for a 1.0 hour period. The batch is cooled to 45° C., 5.32 grams of paraformaldehyde is charged and the batch is slowly heated to 70° C. over a 7.5 hour period. 0.8 grams methane sulfonic acid/70% is charged and mixed at 70° C. for one hour and then the batch is heated to 90° C. over a 1 hour period. 32.27 grams of ethylene glycol are charged and mixed for 1 hour. The batch is cooled to <60° C. and off-loaded. Product is turbid with particles and viscous.

Example 9

83.64 grams of dicyandiamide is added to 108.73 grams of dimethyl sulfoxide and heated under agitation to 90° C. over a 1.0 hour period. The batch is cooled to 45° C., 6.64 grams of paraformaldehyde is charged and the batch is slowly heated to 75° C. over a 3.0 hour period. 1.0 gram methane sulfonic acid/70% is charged and mixed at 75° C. for 1.5 hours and then the batch is heated to 95° C. over a 2 hour period. A vacuum of 20 mm is pulled for 40 minutes, the vacuum is broken and the batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 10

96.8 grams of dicyandiamide is added to 80 grams of dimethyl sulfoxide and heated under agitation to 90° C. over a 0.75 hour period. The batch is cooled to 45° C., 23.05 grams of paraformaldehyde is charged and the batch is slowly heated to 70° C. over a 4.5 hour period. The batch is held at 70° C. for a period of 10 hours. 1.0 gram methane sulfonic acid/70% is charged and mixed at 70° C. for 0.5 hours and then the batch is heated to 95° C. over a 2.25 hour period. A vacuum of 20 mm is pulled for 40 minutes, the vacuum is broken and the batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 11

82.51 grams of dicyandiamide is added to 107.14 grams of dimethyl sulfoxide, heated under agitation to 85° C. and held at 85° C. for 1.25 hour period. The batch is cooled to 45° C., 7.39 grams of paraformaldehyde is charged and the batch is mixed over a 3.5 hour period. The batch is heated to 75° C. over a period of 2.5 hours. 1.0 gram methane sulfonic acid/70% is charged and mixed at 75° C. for 1.5 hours and then the batch is heated to 100° C. over a 2.25 hour period. A vacuum of 50-55 mm is pulled for 30 minutes, the vacuum is broken, 1.97 grams of triethanolamine is charged and the batch is cooled to <60° C. and off-loaded. Product is clear and fluid.

Example 12

106.63 grams of dicyandiamide is added to 106.32 grams of dimethyl sulfoxide, heated under agitation to 85° C. and held at 85° C. for 1.0 hour period. The batch is cooled to 50.8° C., 11.25 grams of paraformaldehyde is charged, and the batch is mixed over a 1.25 hour period. The batch is heated to 85° C. over a period of 5.75 hours. The batch is held at 85° C. for a period of 15 hours. Batch was cooled to 75° C., 1.27 gram methane sulfonic acid/70% is charged, mixed at 75° C. for 1.5 hours and then the batch is heated to 100° C. over a 2.0 hour period. A vacuum of 50-55 mm is pulled for 30 minutes, the vacuum is broken, 2.55 grams of triethanolamine is charged, and the batch is cooled to <60° C. and off-loaded. Product is hazy and viscous.

Example 13

102.44 grams of dicyandiamide is added to 80 grams of dimethyl sulfoxide, heated under agitation to 80° C. and held at temperature for a 1.0 hour period. The batch is cooled to 44.0° C., 14.64 grams of paraformaldehyde is charged and the batch is mixed over a 0.75 hour period. The batch is heated to 85° C. over a period of 2 hours. The batch is held at 80° C. for a period of 1 hour. Batch is cooled to 61° C., 0.88 grams methane sulfonic acid/70% is charged, mixed 1 hour and allowed to exotherm to 70° C. The batch is then heated to 100° C. over a 3.75 hour period. A vacuum of 45-55 mm is pulled for 30 minutes, the vacuum is broken, 2.04 grams of triethanolamine is charged and the batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 14

138.47 grams of dicyandiamide is added to 120 grams of dimethyl sulfoxide, heated under agitation to 80° C., and held at temperature for a 1.0 hour period. The batch is cooled to 60° C., 32.97 grams of paraformaldehyde is charged, and the batch is mixed over a 1.15 hour period. The batch is heated to 80° C. over a period of 2 hours. The batch is cooled to 61° C., 2.57 grams methane sulfonic acid/70% is charged, mixed 1 hour and allowed to exotherm to 70° C. The batch is then heated to 100° C. over a 2 hour period. A vacuum of 45-55 mm is pulled for 30 minutes, the vacuum is broken, 5.99 grams of triethanolamine is charged, and the batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 15

180.18 grams of dicyandiamide is added to 140 grams of dimethyl sulfoxide, heated under agitation to 80° C. and held at temperature for a 1.0 hour period. The batch is cooled to 56° C., 19.01 grams of paraformaldehyde is charged, and the batch is mixed over a 1 hour period. The batch is heated 80° C. over a period of 2 hours. The batch is cooled to 60.3° C., 3.25 grams methane sulfonic acid/70% is charged, mixed 1 hour and allowed to exotherm to 70° C. The batch is then heated to 115° C. over a 6 hour period. A vacuum of 45-55 mm is pulled for 30 minutes, the vacuum is broken, 7.56 grams of triethanolamine and 17.6 grams of tripropylene glycol monomethyl ether are charged and the batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 16

174.57 grams of dicyandiamide is added to 140 grams of dimethyl sulfoxide, heated under agitation to 80° C. and held at temperature for a 1.0 hour period. The batch is cooled to 55° C., 24.94 grams of paraformaldehyde is charged, and the batch is mixed over a 1.15 hour period. The batch is heated 80° C. over a period of 2 hours. The batch is cooled to 60° C., 3.99 grams methane sulfonic acid/70% is charged, mixed 1 hour and allowed to exotherm to 70° C. The batch is then heated to 115° C. over a 4 hour period. A vacuum of 45-55 mm is pulled for 30 minutes, the vacuum is broken, 6.50 grams of triethanolamine is charged and the batch is cooled to <60° C. and off-loaded. Product is clear and viscous.

Example 17

100.45 grams of urea is added to 80 grams of dimethyl sulfoxide, heated under agitation to 80° C. and held at temperature for 1.0 hour period. The batch is cooled to 53.6° C., 2 drops of 45% KOH and 16.74 grams of paraformaldehyde are charged and the batch is mixed over a 1.15 hour period. The batch is heated 75° C. over a period of 2 hours. The batch is held at 75° C. for an additional period of 1 hour. The batch is cooled to 44.7° C., 3.99 grams methane sulfonic acid/70% is charged, mixed 1 hour and allowed to exotherm to 60.7° C. The batch is then heated to 90° C. over a 2 hour period. A vacuum of 45-55 mm is pulled for 30 minutes, the vacuum is broken, 1.88 grams of triethanolamine is charged, and the batch is cooled to <60° C. and off-loaded. Product is opaque and very viscous.

Example 18

142.12 grams of urea is added to 99.58 grams of dimethyl sulfoxide, heated under agitation to 80° C. min and held at temperature for a 1.0 hour period. The batch is cooled to 45° C., 2 drops of 45% KOH and 60.06 grams of paraformaldehyde are charged and the batch is mixed over a 1.15 hour period. The batch is heated 70° C. over a period of 2 hours. The batch is held at 70° C. for an additional period of 1 hour. 128 grams of methanol is charged to the batch. The batch is then heated to reflux for one hour and then cooled to 44.7° C. The pH is adjusted to 5.5-6.5 with nitric acid/20% and the batch is allowed to exotherm to reflux. After 45 minutes, heat is returned to the reactor for 1 hour to maintain reflux. The pH is adjusted to 8.8-9.5 with 45% KOH and methanol/water is removed. When distillation ceases the batch is placed under vacuum of <40 mm until distillation ceases. The batch is cooled to 45° C. The pH is adjusted to 5.5-6.5 with nitric acid/20% and the batch is allowed to exotherm to reflux. After 10 minutes, heat is returned to the reactor for 1 hour to maintain reflux. The pH is adjusted to 8.8-9.5 with 45% KOH and methanol/water is removed. When distillation ceases the batch is placed under vacuum of <40 mm until distillation ceases. The batch is cooled to 45° C. The pH is adjusted to 5.5-6.5 with nitric acid/20% and the batch is allowed to exotherm to reflux. After 10 minutes, heat is returned to the reactor for 1 hour to maintain reflux. The pH is adjusted to 8.8-9.5 with 45% KOH and methanol/water is removed. When distillation ceases, the batch is placed under vacuum of <40 mm until distillation ceases. The batch is cooled to <60° C. and off-loaded. Product is opaque and very viscous. Clear at 70-90° C.

Many of these hydrophobic, biodegradable polymers that have been produced within the NOSDS, dimethyl sulfoxide are high viscosity and a few demonstrate poor shelf stability. Formulations have been prepared utilizing other NOSDSs to impart improvements in these properties. The following table illustrates samples that were formulated using standard overhead mixing and temperatures of 40-120° C.

Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ingredients 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Example 2 62.2 62.6 62.6 62.6 62.6 62.6 62.6 62.6 62.6 Example 6 62.1 62.1 62.1 Example 11 85.0 75.0 Example 17 50.0 TPM 15.0 25.0 DPG 37.9 DMSO 37.8 50.0 DPMAc DimGlut 37.8 Ethyl 37.4 Lactate IPDG 37.4 DBE-3 37.4 PropCarb 37.4 37.9 HexGly 37.4 PG 37.4 EG 37.4 ButCarb 37.9 Appearance Clr Clr P Clr Clr Clr Clr Clr P Clr Clr Clr P Clr Clr Freeze/thaw G G DNR G G G G G DNR G G G DNR G G Clr = Clear P = Poor G = Good DNR = Did not Run TPM: Tripropyleneglycol methyl ether DPG: Dirpopylene Glycol DMSO: Dimethyl Sulfoxide DPMAc: dipropyleneglycol methyl ether acetate DimGlut: Dimethyl Glutarate IPDG: Isopropylideneglycerol DBE-3: dimethyl adipate, glutarate and succinate PropCarb: propylene Carbonate HexGly: Hexylene Glycol PG: propylene glycol EG: ethylene glycol L-62: EO/PO blocked copolymer ButCarb: Butylene Carbonate

Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ingredients 34 35 36 37 38 39 40 41 42 43 44 45 46 47 Example 11 85.0 75.0 Example 12 50.0 50.0 50.0 50.0 Example 13 87.0 64.0 95.0 50.0 75.0 Example 15 95.0 Example 16 50.0 75.0 TPM 50.0 36.0 5.0 5 DPG 15.0 25.0 50.0 50.0 25 50 25 DMSO DPMAc 13.0 L-62 50.0 ButCarb 50.0 Appearance Clr Clr Clr Clr Clr Clr Clr Clr Clr Clr Clr Clr Clr Clr Freeze/thaw G G G G G G G G G G G G G G Clr = Clear P = Poor G = Good DNR = Did not Run TPM: Tripropyleneglycol methyl ether DPG: Dirpopylene Glycol DMSO: Dimethyl Sulfoxide DPMAc: dipropyleneglycol methyl ether acetate DimGlut: Dimethyl Glutarate IPDG: Isopropylideneglycerol DBE-3: dimethyl adipate, glutarate and succinate PropCarb: propylene Carbonate HexGly: Hexylene Glycol PG: propylene glycol EG: ethylene glycol L-62: EO/PO blocked copolymer ButCarb: Butylene Carbonate

The following examples are formulations of the hydrophobic, biodegradable polymers that have been produced within the dimethyl sulfoxide and formulated with other aprotic and protic solvents and biologically active agents such as urease and nitrification inhibitors.

Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex Ingredients 48 49 50 51 52 53 54 55 56 57 Example 32 95.0 Example 33 93.0 Example 34 93.0 Example 35 93.0 Example 36 93.0 Example 37 93 Example 11 85 Example 44 90.9 95 95 N-(n-butyl) 5.0 7.0 7.0 7.0 7.0 7.0 15 thiophosphoric triamide 2-Chloro-6- 9.1 (trichloromethyl)pyridine aminomethyl(N-n 5 butylaminomethyl) phosphinic acid aminomethyl(N-n 5 hexylaminomethyl) phosphinic acid Appearance Clr Clr Clr Clr Clr Clr Clr Clr Clr Clr Freeze/thaw G G G G G G G G G G Clr = Clear P = Poor G = Good DNR = Did not Run Note: dicyandiamide was not included in these experiments since many of the samples already possessed free dicyandiamide such as example 11 and example 12.

As shown by the above examples, biologically active agents can be added to the hydrophobic, biodegradable polymers that have been produced within the NOSDS, dimethyl sulfoxide and further can be added to the hydrophobic, biodegradable polymers that have been produced within the NOSDS, dimethyl sulfoxide and further formulated with protic and aprotic solvents to produce stable products.

A number of the examples were tested for improving urea's resistance to dissolution. The experimental samples were applied to urea using standard overhead mixer with an anchor agitator. The amount of the sample to charge was determined by the specific gravity of the sample times the volumetric treatment level. For example: Determining the amount of Example 32 to be charged at a rate of 3 quarts/ton of urea: Specific gravity=1.163 gm/ml=9.68 lb/gal

-   -   At an application level of 3 quart/ton of urea=7.26 lbs of         Example 32/2000 lbs of urea     -   The application level would be 0.363% of Example 32

The 200 grams of urea was placed in a vessel, agitation was set so not to sling the urea out of the vessel and the calculated amount of the experimental sample was dripped onto the agitating urea. After completing the sample addition, the urea was agitated for an additional minute to insure uniform coverage. Some samples required approximately 1-2% of hydrophobic silica as a flow aide to improve the flow properties of the treated urea. The treated urea was set aside for 24 hours in either at room temperature or at 50° C. The dissolution test method was performed in 100 mls of distilled water in a 150 ml beaker by dropping one granule of either treated or untreated urea into the water. Time was measured from when the urea entered the water until it had dissolved.

Example 58

Treatment level 4 quarts/ton % improvement over Experimental Sample # urea dissolution Ex 19 13% Ex 24 17% Ex 25 33% Ex 22 42%

Example 59

Treatment level 3 quarts/ton 50 C. for 3 days % improvement over Experimental Sample # urea dissolution Ex 31 + silica 77% Ex 31 51% Ex 36 39% Ex 38 + silica 82% Ex 38 + silica 72% Ex 39 46%

Example 60

Treatment level 3 quarts/ton 50 C. for 3 days % improvement over Experimental Sample # urea dissolution Ex 32 41% Ex 33 33% Ex 34 34% Ex 35 77% Note: Testing of Ex 32 & Ex 33 showed a large gel in place of the treated urea that did not disperse for over three days

A couple of experimental samples containing biological active agents were tested for improving urea's resistance to dissolution utilizing the previous testing procedure.

Treatment level 3 quarts/ton 50 C. for 3 days % improvement over Experimental Sample # urea Ex 49 48% Ex 50 22% Ex 57 25%

Example 61

106.82 grams of DMSO and 82.26 grams of DCD were charged to a reaction flask, heated to 86.4° C., held until contents were clear and then cooled to 50° C. 7.37 grams of paraformaldehyde were charged and then mixed for 30 minutes. The contents were then heated to 86.2° C. over a 3 hour period and held until the solution became clear. The contents were cooled to 59.9° C. and then 1.19 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were slowly heated to 110° C. over a 2.5 hr period of time. At 110° C., a vacuum of 45-65 mm Hg was applied to the reaction flask for 0.5 hrs, the vacuum was broken with nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 11.26 grams, the yield 178.82 grams and the calculated amount of DCD was 46.21%.

Example 62

106.82 grams of DMSO and 82.26 grams of DCD were charged to a reaction flask, heated to 95° C., held until contents were clear and then cooled to 65° C. 7.37 grams of paraformaldehyde were charged and the contents were then heated to 81° C. over a 0.75 hour period and held 1.3 hrs until the solution became clear. The contents were cooled to 41.7° C. and then 1.19 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were slowly heated to 110° C. over a 2.1 hr period of time. At 110° C., a vacuum of 54-65 mm Hg was applied to the reaction flask for 0.8 hr, the vacuum was broken by nitrogen, 2.37 grams of triethanolamine/99% were charged and then the contents were cooled to <45° C. and packaged. The yield 189.08 grams and the calculated amount of DCD was 43.5%.

Example 63

101.6 grams of DMSO and 87.05 grams of DCD were charged to a reaction flask, heated to 110° C., held until contents were clear and then cooled to 60° C. 7.80 grams of paraformaldehyde were charged and then the contents were heated to 85° C. over a 8.5 hour period. 1.19 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were slowly heated to 95° C. over a 2 hr period of time. At 95° C., a vacuum of 35-50 mm Hg was applied to the reaction flask for 0.5 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The yield 189.4 grams and the calculated amount of DCD was 45.96%.

Example 64

140 grams of DMSO and 174.57 grams of DCD were charged to a reaction flask, heated to 82° C., held for 1 hr and then cooled to 65° C. 24.94 grams of paraformaldehyde were charged, the contents were then heated to 75° C. and held at temperature for 3.5 hrs. 3.99 grams of methane sulfonic acid/70% were added over a 0.75 hr period, the contents were mixed for 5 minutes and then the contents were slowly heated to 110° C. over a 2.1 hr period of time. At 110° C., a vacuum was applied to the reaction flask for 0.8 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The yield 309.5 grams and the calculated amount of DCD was 57.24%.

Example 65

140 grams of DMSO and 162.12 grams of DCD were charged to a reaction flask, heated to 82° C. and held for 1 hr and then cooled to 65° C. 38.60 grams of paraformaldehyde were charged, mixed for 0.5 hr and the contents were then heated to 85° C. over a 3.75 hr period and held at temperature for 0.75 hrs. 3.53 grams of methane sulfonic acid/70% were added over a 0.3 hr period, the contents were mixed for 5 minutes and then the contents were slowly heated to 110° C. over a 3.8 hr period of time. At 110° C., a vacuum of 27-31 mm Hg was applied to the reaction flask for 0.7 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 33.15 grams, the yield 299.03 grams and the calculated amount of DCD was 53.33%.

Example 66

140 grams of DMSO and 153.37 grams of DCD were charged to a reaction flask, heated to 85° C., held for 1 hr. 45.65 grams of paraformaldehyde were charged, mixed for 0.5 hr and then the contents were then heated to 85° C. over a 3.75 hr period and held at temperature for 1.25 hrs. 4.17 grams of methane sulfonic acid/70% were added over a 0.25 hr period, the contents were mixed for 5 minutes and then the contents were slowly heated to 110° C. over a 4.5 hr period of time. At 110° C., a vacuum of 23.6-31 mm Hg was applied to the reaction flask for 0.5 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 46.09 grams, the yield 287.27 grams and the calculated amount of DCD was 52.35%.

Example 67

181.18 grams of DMSO and 144.87 grams of DCD were charged to a reaction flask, heated to 85° C., held for 1 hr and then cooled to 65° C. 13.45 grams of paraformaldehyde were charged, mixed for 0.5 hr and the contents were then heated to 110° C. over a 9.5 hr period and held at temperature for 0.5 hrs. No methane sulfonic acid/70% was added. The contents were cooled to 90° C. over a 0.5 hr period of time. At 90° C., a vacuum of 28-31 mm Hg was applied to the reaction flask for 0.5 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 49.27 grams, the yield 329.93 grams and the calculated amount of DCD was 43.91%.

Example 68

181.18 grams of DMSO and 144.87 grams of DCD were charged to a reaction flask, heated to 80° C. and held for 1 hr. At 80° C., 13.45 grams of paraformaldehyde were charged, mixed for 0.5 hr and the contents were then heated to 85° C. and held at temperature for 8.5 hrs. No methane sulfonic acid/70% was added. The contents were heated to 90-95° C. and held at temperature for a 12 hr period of time. At 90° C., a vacuum of 22.3-28.0 mm Hg was applied to the reaction flask for 1.0 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 11.36 grams, the yield 322.35 grams and the calculated amount of DCD was 44.95%.

Example 69

179.47 grams of DMSO and 144.28 grams of DCD were charged to a reaction flask and heated to 45° C. and an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. 13.74 grams of paraformaldehyde were charged and mixed for 0.5 hr and the contents were then heated to 90° C. over a 9 hr period. At 90° C. 2.04 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were slowly heated to 95° C. and held for a 2 hr period of time. At 95° C., a vacuum of 28 mm Hg was applied to the reaction flask for 0.5 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 11.55 grams, the yield 322.37 grams and the calculated amount of DCD was 44.76%.

Example 70

179.47 grams of DMSO and 144.28 grams of DCD were charged to a reaction flask and heated to 40° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. 13.74 grams of paraformaldehyde were charged and mixed for 0.5 hr and the contents were then heated to 112.6° C. over a 6.5 hr period. No methane sulfonic acid/70% was added. At 110° C., a vacuum of 2 mm Hg was applied to the reaction flask for 0.5 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 19.17 grams, the yield 314.18 grams and the calculated amount of DCD was 45.65%.

Example 71

179.47 grams of DMSO, 13.74 grams of paraformaldehyde and 144.28 grams of DCD were charged to a reaction flask at a temperature of 35° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. mixed for 0.5 hr and the contents were then heated to 100° C. over a 2 hr period and held at 100° C. for a period of 5 hrs. No methane sulfonic acid/70% was added. At 100° C., a vacuum was applied to the reaction flask for 0.7 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 18.4 grams, the yield 313.8 grams and the calculated amount of DCD was 45.70%.

Example 72

179.47 grams of DMSO, 13.74 grams of paraformaldehyde and 144.28 grams of DCD were charged to a reaction flask at a temperature of 35° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. mixed for 0.5 hr and the contents were then heated to 80° C. over a 2 hr period and held at 80° C. for a period of 7 hrs. At 80° C. 2.04 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were mixed at 80° C. for a 1 hr period of time. The contents were then heated to 90 C and a vacuum was applied to the reaction flask for a period of 2 hr, the vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 13.47 grams, the yield 320.65 grams and the calculated amount of DCD was 46.39%.

Example 73

193.68 grams of DMSO and 104.19 grams of DCD were charged to a reaction flask at a temperature of 18° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. 16.91 grams of paraformaldehyde charged, mixed for 0.25 hr and the contents were then heated to 70° C. over a 0.5 hr period and held at 70° C. for a period of 13 hrs. No methane sulfonic acid/70% was added. The contents were then heated to 90 C and held for 4 hours. 35.22 grams of DCD were charged a vacuum of 15 mm Hg was applied to the reaction flask for a period of 1.5 hr while the temperature was allowed to cooled to 80° C. The vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 15.86 grams, the yield was 329.73 grams and the calculated amount of DCD was 42.12%.

Example 74

204.23 grams of DMSO and 120.84 grams of DCD were charged to a reaction flask at a temperature of 18° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. 19.62 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 70° C. over a 0.5 hr period and held at 70° C. for a period of 3.5 hrs. At 70° C., 2.08 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were mixed at 70° C. for a 1 hr period of time. The contents were then heated to 80 C and held for 3 hours at temperature and under a vacuum. The vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 17.89 grams, the yield was 326.32 grams with a strong smell of formaldehyde and the calculated amount of DCD was 36.69%.

Example 75

204.23 grams of DMSO and 120.84 grams of DCD were charged to a reaction flask at a temperature of 18° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 19.62 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 84.3° C. over a 0.5 hr period and held at 80° C. for a period of 3.5 hrs. At 80° C., 2.08 grams of methane sulfonic acid/70% were added and mixed for 1 hr, At 80° C., the contents were placed under a vacuum of 15-30 mm Hg and held at 80° C. for a period of 1.5 hr. The contents were then heated to 90 C and held for 3 hours at temperature and under a vacuum. The vacuum was broken by nitrogen, 3.23 grams of triethanolamine/99% was charged and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 28.93 grams, the yield was 315.99 grams and the calculated amount of DCD was 38.24%.

Example 76

754.11 grams of DMSO and 619.74 grams of DCD were charged to a reaction flask at a temperature of 20° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 63.19 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 80° C. over a 0.75 hr period and held at 80° C. for a period of 6 hrs. At 80° C., 8.67 grams of methane sulfonic acid/70% were added. The contents were mixed for 5 minutes and then the contents were placed under a vacuum of <50 mm Hg for period of a 1 hr. The contents were then heated to 90-95° C. and held for 4.5 hours at temperature and under a vacuum. The vacuum was broken by nitrogen, a portion was removed for analytical purpose (coded Example 76 base) and then 9.42 grams of triethanolamine/99% and 29.95 grams of a polysuccinimide were charged and mixed until homogeneous. The contents were cooled to <45° C. and packaged. The data of the example 76 base is the amount of distillate collected was 42.09 grams, the yield was 1425.28 grams and the calculated amount of DCD was 44.95%.

Example 77

71.01 grams of DMSO and 66.72 grams of 3,5-dimethylpyrazole were charged to a reaction flask at a temperature of 18° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 10.42 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 80.0° C. over a 4.0 hr period. At 80° C., 0.89 grams of methane sulfonic acid/70% was added and mixed for 1 hr. The contents were then heated to 110 C over a period of time of 2.5 hrs and held for 0.5 hours at temperature. Contents were cooled to 90° C. and placed under a vacuum of 29 mm Hg for a period of time of 1.5 hrs. The vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 9.55 grams and the yield was 135.28.

Example 78

75.28 grams of DMSO and 61.87 grams of DCD were charged to a reaction flask at a temperature of 20.4° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 11.05 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 80° C. held at 80° C. over a 3.0 hr period of time. At 80° C., 0.87 grams of methane sulfonic acid/70% was added and mixed for 1 hr. At 80° C., the contents were placed under a vacuum of 15-30 mm Hg and the contents were then heated to 90 C and held for 0.3 hours at temperature and under a vacuum. The vacuum was broken by nitrogen, and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 9.45 grams, the yield was 132.71 grams with a slight smell of formaldehyde and the calculated amount of

DCD was 46.62%.

Example 79

70.44 grams of DMSO and 59.88 grams of DCD were charged to a reaction flask at a temperature of 18.6° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 17.82 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 80° C. held at 80° C. over a 2.0 hr period of time. At 80° C., 0.89 grams of methane sulfonic acid/70% was added and the contents were placed under a vacuum of 16-30 mm Hg for a period of 0.5 hrs. The contents were then heated to 90 C and held for a period of 2 hours at temperature and under a vacuum of 16 mm Hg. The vacuum was broken by nitrogen, the vessel was placed under vacuum and then the vacuum was broken by a hard sparge of nitrogen (was repeated 3 times) and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 12.01 grams, the yield was 129.0 grams and the calculated amount of DCD was 46.12%.

Example 80

23.67 grams of sulfolane and 22.24 grams of 3,5-dimethylpyrazole were charged to a reaction flask at a temperature of 18° C., 10.42 grams of paraformaldehyde were charged and mixed for 0.25 hr and the contents were then heated to 80.0° C. over a 2.0 hr period. At 80° C., 0.30 grams of methane sulfonic acid/70% was added and mixed for 1 hr. The contents were then heated to 100 C over a period of time of 1 hr and held for 0.5 hours at temperature. Contents were placed under a vacuum of 19 mm Hg for a period of time of 0.5 hrs. The vacuum was broken by nitrogen and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 0 grams and the yield was 47.7 grams.

Example 81

64.72 grams of DMSO, 55.03 grams of DCD and 12.16 grams of 3,5-dimethylpyrazole were charged to a reaction flask at a temperature of 20.4° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 19.44 grams of paraformaldehyde, contents were mixed for 0.25 hr and the contents were then heated to 80° C. held at 80° C. over a 2.0 hr period of time. Contents were cooled to 60° C. and 0.91 grams of methane sulfonic acid/70% was added, the contents were placed under a vacuum of 15 mm Hg and the contents were then heated to 90 C and held for 3 hours at temperature and under a vacuum. The vacuum was broken by nitrogen, 0.99 grams of triethanolamine/99% were charged and then the contents were cooled to <45° C. and packaged. The amount of distillate collected was 13.94 grams, the yield was 126.98 grams and the calculated amount of DCD was 43.58%.

Example 82

77.74 grams of DMSO and 63.88 grams of DCD were charged to a reaction flask at a temperature of 15.4° C., an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times, charged 6.51 grams of paraformaldehyde mixed for 0.25 hr and the contents were then heated to 80° C. held at 80° C. over a 3.0 hr period of time. Contents were cooled 40° C., 0.89 grams of pTSA was added and the contents were placed under a vacuum of 29-30 mm Hg. The contents were then heated to 90 C and held for a period of 2 hours at temperature and under a vacuum of 21 mm Hg. The vacuum was broken by nitrogen, ½ of the contents were removed and coded Example 82 and then Example 82 was cooled to <45° C. and packaged. The amount of distillate collected was 6.48 grams, the yield was 139.48 grams and the calculated amount of DCD was 45.8%. The remaining content was continued as Example 83.

Example 83

The remaining contents of Example 82 in the reaction flask were heated to 90-95° C. and 10 grams of distilled water were added. The contents were held at 90-90° C. for a period of 2 hrs and then placed under vacuum until charged water was removed (approx. 11.6 grams of distillate recovered). The contents were then cooled and packaged.

Example 84

Heat 51.6 grams of DMSO to 60° C. under agitation and then charge 48.4 grams of 3,5-dimethylpyrazole (DMP). Mix @ 60° C. until clear. Package in a seal container and maintain sample @ 50-70° C. for clarity and homogeneity Example 85 Aluminum weigh pans were weighed and the weight recorded. Approximately 2 grams of sample were weighed into aluminum weigh pan and then placed in an oven @60° C. for 24 hours. After 24 hours, the sample in the aluminum weigh pan was removed from the oven and weighed. The weights were compared and percentage of non-volatile matter was calculated as shown in Chart 1.

CHART 1 Weight pan Sample after 24 % Example wt initial wt difference hrs @60° C. remaining *DMSO 2.645 3.674 1.029 2.645   0% Example 2.644 4.874 2.230 3.251 27.22%  77 Example 2.633 4.836 2.203 2.642 0.41% 84 *DMSO was 0% remaining after 12 hrs

The results of the volatility test show that the DMP oligomer from example 67 has >50% weight retention versus unreacted DMP from Example 84. The >50% is based on the results that show DMSO has completely volatilized in 24 hours and the footnote that states this volatility occurred after 12 hours.

Example 86

90.9 grams of Example 61 were blended with 9.1 grams of propylene glycol at 30° C. and then packaged. Sample appearance was clear.

Example 87

90.9 grams of Example 61 were blended with 9.1 grams of ethylene glycol at 30° C. and then packaged. Sample appearance was clear.

Example 88

91.4 grams of Example 63 were blended with 8.62 grams of DMSO at 30° C. and then packaged. Sample appearance was clear.

Example 89

91.4 grams of Example 63 were blended at 30° C. with 8.62 grams a 50% ammonium neutralized polyaspartate (polyaspartate polymer weight 3000-5000 grams/mole) dispersed in DMSO and then packaged. Sample appearance was clear.

Example 90

30 grams of Example 64 were blended with 44.45 grams of DMSO, 0.3 grams of triethanolamine, 25.25 grams of DCD were heated to 80° C. mixed until clear, cooled to <40 C and then packaged. Sample appearance was clear.

Example 91

30 grams of Example 65 were blended with 43.54 grams of DMSO, 0.3 grams of triethanolamine, 26.16 grams of DCD were heated to 80° C. mixed until clear, cooled to <40° C. and then packaged. Sample appearance was clear.

Example 92

78.6 grams of Example 64 were blended with 21.4 grams of DMSO at 30° C. and then packaged. Sample appearance was clear.

Example 93

78.6 grams of Example 64 were blended with 21.4 grams of ethylene glycol at 30° C. and then packaged. Sample appearance was clear.

Example 94

78.6 grams of Example 64 were blended with 21.4 grams of polyethylene glycol at 30° C. and then packaged. Sample appearance was clear.

Example 95

83 grams of Example 65 were blended with 17 grams of DMSO at 30° C. and then packaged. Sample appearance was clear.

Example 96

85.13 grams of Example 65 were blended with 14.9 grams of DMSO at 30° C. and then packaged. Sample appearance was clear.

Example 97

97 grams of Example 68 were blended with 2 grams of a polysuccinimide (polymer weight 3000-5000 grams/mole) and 1 gram of a solvent dispersed blue dye at 60° C. and cooled and package. Sample appearance was blue and clear.

Example 98

81.84 grams of Example 73 were blended with 0.66 grams of DMSO, and 14.50 grams of DCD were heated to 80° C. mixed until clear, cooled to <40 C and then packaged. Sample appearance was clear.

Example 99

30 grams of Example 73 were blended at 30° C. with 70 grams a 50% ammonium neutralized polyaspartate (polyaspartate polymer weight 3000-5000 grams/mole) dispersed in DMSO and then packaged. Sample appearance was clear.

Example 100

41.72 grams of Example 73 were blended with 25 grams of a polysuccinimide (polymer weight 3000-5000 grams/mole) and 33.29 grams DMSO at 60° C. and cooled and package. Sample appearance was clear.

Example 101

28.57 grams of tripropylene glycol methyl ether were blended with 0.5 grams of triethanolamine and 40.0 grams of Example 73 and then heated to 40° C. While mixing, 30.93 grams of N-(-n-butyl) thiophosphoric triamide were added and mixed until all particles were dissolved. The sample was clear and packaged.

Example 102

Blends in examples 86-101 were evaluated for sample storage stability and are listed in

Chart 2:

CHART 2 Freeze Stable @ thaw Stable @ 25° C. for 7 stable 50° C. for 3 Example # days (3 times) days 86 Pass Pass Pass 87 Pass Pass Pass 88 Pass Pass Pass 89 Pass Pass Pass 90 Pass Pass Pass 91 Pass Pass Pass 92 Pass Pass Pass 93 Pass Pass Pass 94 Pass Pass Pass 95 Pass Pass Pass 96 Pass Pass Pass 97 Pass Pass Pass 98 Pass Pass Pass 99 Pass Pass Pass 100 Pass Pass Pass 101 Pass Pass Pass

Evaluation shows that blended formulations have good storage stability.

Example 103

Some of the samples were analyzed for viscosity, pH, formaldehyde content and dispersibility in distilled water to yield a borderline translucent dispersion. The results as well as the molar ratio of the reactants are as shown in Chart 3:

CHART 3 ratio of DCD to one Brookfield pH *Dispersion ppm free Example # mole of formaldehyde Viscosity (5%) of samples formaldehyde ***62 3.988 214 8.32 0.717 103 63 3.988 48 88 Adjusted Ex #63 0.960 ***90 Ex #64 adjusted with 119 8.22 0.860 148 DMSO and Free DCD 64 2.5 ***91 Ex #65 adjusted with 173 8.22 0.586 198 DMSO and Free DCD 65 1.5 **67 3.85 320 8.6 4.800 53 68 3.85 2.452 54 69 3.75 354 7.1 2.877 59 **71 3.75 2.181 206 72 3.75 330 7.05 3.615 490 **73 2.2 adjusted insitu with 203 8.11 2.336 118 free DCD 76 3.5 275 7.17 1.685 66 78 2 820 7.12 2.988 603 79 1.2 4780 7.09 0.700 180 82 3.5 275 7.15 3.920 41 83 3.5 303 7.25 1.070 21 *grams of sample in 100 grams of Distilled Water (Barely Translucent in Appearance) **No acid catalyst charged ***sample contains triethanolamine

Most of the viscosity, pH and free formaldehyde data in Chart 3 are within expected ranges. However, some of the examples required further dilution to test dispersibility. Most of the above samples that did not need dilution contain 42-46% polymer bound and free DCD. One example (e.g., example #63) required additional dilution to achieve a total DCD with DMSO of 43-44%. Similarly, examples #90 and #91 represent adjusting examples #64 and #65 to achieve a total DCD with DMSO of 43-44%, and also achieved a ratio of polymer bound to free DCD ratios close to the 52:48 of other examples.

It was expected that examples produced with similar molar ratios would have similar dispersibility in water. It was also expected that water dispersibility would decrease as the DCD to formaldehyde ratio decreased which would result in an increase in polymer bound to free DCD ratio. Comparing the water dispersibility of examples 62 and 88 to examples 67 and 68 did not support this expectation. Without being bound by theory, it is believed that the variation in solubility is related to the cyano group's presence as well as the distribution of polymer molecular weight (i.e., if more of the higher molecular species are present, the water solubility is diminished). Reaction parameters such as catalyst versus non-catalyst, the temperature at which the catalyst is charged, the time and temperatures of the process conditions, the speed of removal of water either from the catalyst charge or from the by-product, water from the second reaction and the % of a NAPAOL in the reaction composition are believed to be the conditions that influence water solubility.

Example 104

To determine the percent retention of the cyano group present in the examples, an UV analytical procedure was ran in which a calculated concentration of total (polymer found and free) DCD for a number of examples was performed and a dilution of the examples were performed to reach a calculated concentration of total DCD of 8.7 ppm using a isopropanol/water solvent system.

Procedure:

-   -   1) A UV spectrophotometer, DU Beckman 640, was utilized to         determine the absorbance at specific UV wavelength of a diluted         sample that was contained in a 10 mm Quartz Cuvette     -   2) A blank was prepared that included water, propanol and NAPAOL         in the amounts present in the dilution of an example to 8.7 ppm         of total DCD.     -   3) A standard curve was plotted for UV absorbance for known         concentrations of DCD solutions of 8.7 ppm, 8.4 ppm, 8.0 ppm and         7.6 ppm representing respectively 43.5%, 42%, 40% and 38% DCD in         solution. FIG. 1 is the plot of DCD concentration versus UV         absorbance @ 211-216 nm.     -   4) The calculated concentration of examples was adjusted to a         43.5% level during the dilution process as shown in Chart 4:

CHART 4 Dil 1 Dil 2 Dil 3 Calculated Weight Total Total Dil 4 total of DCD DCD Total DCD Example # DCD Example conc conc Conc 62 43.50% 5.00 0.2175 0.0004350 0.0000087 88   42% 5.18 0.2175 0.0004350 0.0000087 90 42.42% 5.13 0.2175 0.0004350 0.0000087 91 42.42% 5.13 0.2175 0.0004350 0.0000087 67 43.91% 4.95 0.2175 0.0004350 0.0000087 68 44.94% 4.84 0.2175 0.0004350 0.0000087 69 44.76% 4.86 0.2175 0.0004350 0.0000087 71 45.70% 4.76 0.2175 0.0004350 0.0000087 72 46.39% 4.69 0.2175 0.0004350 0.0000087 73 42.13% 5.16 0.2175 0.0004350 0.0000087 76 43.33% 5.02 0.2175 0.0004350 0.0000087 78 46.62% 4.67 0.2175 0.0004350 0.0000087 82 45.80% 4.75 0.2175 0.0004350 0.0000087 83 45.80% 4.75 0.2175 0.0004350 0.0000087 Dil-1: weight of example in 45 grams of 50/50 IPA/Water to yield concentration of total DCD of 4.35% Dil-2: 5 grams of Dil 1, & 45 grams 50/50 IPA/Water Dil-3: 50 grams Dil 2/450 Water Dil-4: 2 gm Dil 3/100 mls

Each sample dilution was placed in the Beckman DU 640 Spectrophotomer and read and recorded 4 times at UV wavelengths of 211-216 nm. Chart 5 shows the average of the three highest UV absorbance readings at 211-216 nm and the resulting sample's absorbance is compared to the concentration curve of the standard for DCD to estimate the sample's % total DCD.

CHART 5 estimated Average of Total UV DCD Estimated Absorbance versus % cyano- Example # Readings standard retained Standard 1.467 43.50% 62 1.395 41.80% 96.09% 88 1.334 40.55% 93.22% 90 1.305 39.95% 91.84% 91 1.278 39.40% 90.57% 67 1.365 41.20% 94.71% 68 1.313 40.15% 92.30% 69 1.343 40.80% 93.79% 71 1.331 40.60% 93.33% 72 1.316 40.25% 92.53% 73 1.378 41.50% 95.40% 76 1.400 42.05% 96.67% 78 1.331 40.50% 93.10% 82 1.426 42.50% 97.70% 83 1.281 39.50% 90.80%

Comparison of the data from example 62 and example 88 shows a significant drop in absorbance of example 88 indicating a loss of cyano-function. Examination of the reaction conditions for both examples reveals that even though example 62 was heated to 118° C., the methane sulfonic acid (MSA)/70% catalyst was charged at 42° C., whereas the reaction product for example 88 (example 63) was only heated to 95° C., the MSA/70% catalyst was charged at 85° C. Without being bound by theory, it is believed that the time, the temperature of the contents of the reaction vessel, the temperature at which the catalyst is introduced and the presence or absence of water have a major impact on cyano-function loss.

Examples 90, 91 and 73 are examples of low ratio DCD:Formaldehyde where the final ratio of polymer bound and free DCD are adjusted by the post reaction addition of free DCD. Examples 90 and 91 have low absorbance readings while example 73 has higher absorbance readings. Examples 90 and 91 were based on the reaction product of examples 64 and 65 respectively where the MSA/70% was charged at 85° C. and the reaction was heated to 110° C., removal of water was at the end of the reaction phase and the % composition of DMSO was around 45% during the reaction. Example 73 was at approximately 65% DMSO during the reaction phase and the MSA/70% was charged at 70° C. and the extra DCD was charged and the reactor placed under vacuum to remove the water by-product during the second reaction.

Examples 76, 82 and 83 are very similar in formulation and in process with the exception that example 76 has the catalyst MSA/70 charged to the reaction vessel at 80° C. while Example 82 utilizes the catalyst pTSA/100% and the catalyst is charged to the reaction vessel at 38° C. Without being bound by theory, it is believed that the catalyst MSA/70 contains some water, which degrades the cyano group. In comparison the catalyst pTSA/100% is substantially free of water and consequently does not degrade the available cyano groups. This theory is further supported by Example 83, which is example 82 with approximately 9-10% distilled water added. In both examples 82 and 83, the water is stripped out.

The UV absorption results show that utilizing a non-water containing catalyst that is charged at a low temperature results in higher absorption readings. Example 83 shows that the presence of water during reaction temperature results in lower UV absorption numbers.

Example 105

35 grams of DMSO was warmed to 45° C., then 15 grams of 2-chloro-6-trichloromethyl)pyridine was charged and the composition was mixed for 45 minutes until mixture was clear. 50 grams of Example 76 was charge and the new composition was mixed for 1 hour. The product was packaged. A check of the sample after 6 weeks of storage found it was still clear. Another sample of the composition was placed in an oven @ 50° C. and after three days was found to be stable.

Example 106

49.44 grams of example 76 were charged to reaction flask and placed under agitation. The pH was adjusted to 9.6 with NaOCH₃/25% and agitated for 15 minutes. 5.56 grams of paraformaldehyde were charged and composition was heated to 70° C. and held for five hours and then heated to 80° C. for 30 minutes. The composition was then cooled to 40° C. and held under agitation. The appearance of the composition was slightly hazy.

Example 107

To reactor 285 grams of molten urea was charged and then the vessel was deoxygenate 3 times by evacuating with vacuum and sparged with ammonia gas to slow degradation of urea under molten conditions. All sparging tubes and thermometers had to be removed to prevent breakage and an a stainless steel agitator shaft and blade were utilized due to the difficulty in agitating granular urea.

The urea was heated with agitation until molten and then the thermometer and sparge tube were re-inserted. The temperature reading was 148.3° C. and the molten urea was again sparged with ammonia gas. 15 grams of Example 106 were slowly charged to the molten urea while controlling the exotherm with charge rate and removing heating mantel. After 30 minutes, example 106 charge was completed and the composition was agitated at 145-155° C. under an ammonia atmosphere to 15 minutes. The composition had a slight hazy appearance and was then poured on a dimpled steel sheet, cooled and packaged for further evaluation.

Example 108

15.17 grams of dicyandiamide were charged to reaction flask that contained 29.0 grams of DMSO under agitation. The composition was heated to 80° C. and mixed at 80° C. until the dicyandiamide had dissolved. The composition was then cooled to 45° C. where 10.83 grams of paraformaldehyde were charged and mixed until a consistent slurry was formed.

Example 109

To reactor 285 grams of molten urea was charged and then the vessel was deoxygenate 3 times by evacuating with vacuum and sparged with ammonia gas to slow degradation of urea under molten conditions. All sparging tubes and thermometers had to be removed to prevent breakage and an a stainless steel agitator shaft and blade were utilized due to the difficulty in agitating granular urea. The urea was heated with agitation until molten and then the thermometer and sparge tube were re-inserted. The temperature reading was 148.3° C. and the molten urea was again sparged with ammonia gas. 15 grams of Example 108 were slowly charged to the molten urea while controlling the exotherm with charge rate and removing heating mantel. After 30 minutes, example 106 charge was completed and the composition was agitated at 145-155° C. under an ammonia atmosphere to 15 minutes. The composition showed a slight milky appearance and was then poured on a dimpled steel sheet, cooled and packaged for further evaluation.

Example 110

49.48 grams of example 79 and 20 grams of DMSO were charged to reaction flask and placed under agitation. The pH was adjusted to 9.4 with NaOCH₃/25% and agitated for 15 minutes. 5.52 grams of paraformaldehyde were charged and composition was heated to 70° C. and held for five hours and then heated to 80° C. for 30 minutes. The composition was then cooled to 40° C. and held under agitation. The appearance of the composition was slightly hazier than example 106 and slightly viscous.

Example 111

To reactor 285 grams of molten urea was charged and then the vessel was deoxygenate 3 times by evacuating with vacuum and sparged with ammonia gas to slow degradation of urea under molten conditions. All sparging tubes and thermometers had to be removed to prevent breakage and an a stainless steel agitator shaft and blade were utilized due to the difficulty in agitating granular urea. The urea was heated with agitation until molten and then the thermometer and sparge tube were re-inserted. The temperature reading was 148.3° C. and the molten urea was again sparged with ammonia gas. 15 grams of Example 110 were heated to 65° C. were slowly charged to the molten urea while controlling the exotherm with charge rate and removing heating mantel. After 30 minutes, example 106 charge was completed and the composition was agitated at 145-155° C. under an ammonia atmosphere to 15 minutes. The composition had a slight hazier appearance compared to example 107 and was then poured on a dimpled steel sheet, cooled and packaged for further evaluation.

Example 112

A number of the examples were tested for nitrification inhibition on urea. The experimental samples were applied to urea using standard overhead mixer with an anchor agitator. The amount of the sample to charge was determined by the specific gravity of the sample times the volumetric treatment level. For example:

Determining the amount of Example 76 to be charged at a rate of 3 quarts/ton of urea:

-   -   Specific gravity=1.163 gm/ml=9.68 lb/gal     -   At an application level of 3 quart/ton of urea=7.26 lbs of         Example 76/2000 lbs of urea     -   The application level would be 0.363% of Example 76

The 200 grams of urea was placed in a vessel, agitation was set so not to sling the urea out of the vessel and the calculated amount of the experimental sample was dripped onto the agitating urea. After completing the sample addition, the urea was agitated for an additional minute to insure uniform coverage.

The examples 62, 68, 73, 75 and 76 were adjusted to a calculated DCD level of 30% with DMSO and FD&C Blue #1 Food Color as shown in the Chart 6:

CHART 6 Ingredients DCD/30% Ex-62/30% Ex-68/30% Ex-73/30% Ex-75/30% Ex-76/30% DCD-34% 88.3% DMSO 10.5% 29.73 31.94 27.54 18.49 27.27 FD&C 1.2% 1.3 1.3 1.3 1.3 1.3 Blue #1 Example 62 68.97 Example 68 66.76 Example 73 71.16 Example 75 80.21 Example 76 71.43

Each sample was applied to 200 grams of urea at a 3 quart/ton application rate.

Example 113

In 143.5 cubic inch plastic containers with a hole in the side large enough for a Drager tube to be safely inserted, 200 grams of West Texas Soil (Estacado Clay Loam) with a moisture content of 37% and 75 grams of distilled water were added and mixed. The surface area of the soil was calculated to 47.8 sq inches. Exactly 1.1 grams of each urea sample was added to the surface of the soil and the plastic container and its hole were sealed. The headspace of each sealed container was analyzed for ppm ammonia by using a handheld Drager pump attached to the Drager tube which was inserted into the plastic container's hole and the pump was manually engaged 10 times. The readings were then recorded. Regardless of whether a reading of ppm ammonia was made each day on the samples' containers, each container was opened and fanned to insure that the reading of ammonia build up was for a 24 hour cycle. The results of test are in the Chart 7 which provides the data for graph listed as “FIG. 6” ((good nitrification inhibition results in high ammonia ppm readings):

CHART 7 Ammonia Generated (ppm) Sample Days ID on 5 6 10 11 13 17 20 24 27 Urea (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) DCD/30% 300 625 500 520 600 550 490 380 300 Example 275 610 600 610 750 700 560 875 700 73/30% Example 550 600 615 600 725 675 620 690 600 76/30% Urea 50 100 420 540 700 450 420 350 200 (untreated)

A nitrate concentration analysis was performed on the soil after 30 days using a standard colormetric method in which a 1M KCl extraction of the soil is performed and is then passed through a copperized cadmium column. After diazotizing with sulfanilamide and followed by coupling with N-(1-naphthyl)ethylenediamine dihydrochloride, a color intensity is read at 520 nm. The Chart 8 contains the results of the analysis (good nitrification inhibition results in low nitrate ppm readings):

CHART 8 Sample ID on ppm of urea nitrate DCD/30% 9 Example <1 73/30% Example <1 76/30% Urea 81 (untreated)

Example 73 and Example 76 were combinations of DCD-formaldehyde oligomer with free DCD. While both were similar in composition, the free DCD was added to Example 73 post reaction while the free DCD was present during the reaction in Example 76. Because of the composition of the reactants in both examples, one would expect a broader oligomer/polymer molecular weight distribution in example 73 due to the 2.2:1 DCD to formaldehyde molar ratio while the excess DCD present in the reaction of example 76 due to the 3.5:1 DCD to formaldehyde ratio would result in a higher percentage of the methylene bis dicyandiamide oligomer. Results showed that both examples out performed DCD by itself.

Example 114

In 66.1 cubic inch plastic containers with a hole in the side large enough for a Drager tube to be safely inserted, 200 grams of West Texas Soil (Estacado Clay Loam) with a moisture content of 37% and 75 grams of distilled water were added and mixed. The surface area of the soil was calculated to 33.1 sq inches. Exactly 0.75 grams of each urea sample was added to the surface of the soil and the plastic container and its hole were sealed. The headspace of each sealed container was analyzed for ppm ammonia by using a handheld Drager pump attached to the Drager tube which was inserted into the plastic container's hole and the pump was manually engaged 10 times. The readings were then recorded. Regardless of whether a reading of ppm ammonia was made each day on the samples' containers, each container was opened and fanned to insure that the reading of ammonia build up was for a 24 hour cycle. The results of test are in the Chart 9 below which provides the data for graph listed as “FIG. 7”:

CHART 9 Ammonia Generated (ppm) Impact of conserving cyano group *Estimated % Sample cyano Days ID opn group 7 11 14 18 21 25 28 32 urea retained (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) Example 96.09% 95 225 540 620 580 290 210 62/30% Example 92.30% 45 180 300 560 500 190 150 68/30% Example 96.67% 50 200 580 670 640 540 290 140 76/30% *From Example # 104/Chart #5

Example 62, Example 68 and Example 76 were combinations of DCD-formaldehyde oligomer with free DCD. All three were similar in composition and the free DCD was present during the reaction in in all three examples. Because of the composition of the reactants in the three examples are close, one would expect similar nitrification inhibition properties. However, the lower cyano group retention negatively impacted the nitrification inhibition of example 68.

Example 115

In 66.1 cubic inch plastic containers with a hole in the side large enough for a Drager tube to be safely inserted, 200 grams of West Texas Soil (Estacado Clay Loam) with a moisture content of 37% and 75 grams of distilled water were added and mixed. The surface area of the soil was calculated to 33.1 sq inches. Exactly 0.75 grams of each urea sample was added to the surface of the soil and the plastic container and its hole were sealed. The headspace of each sealed container was analyzed for ppm ammonia by using a handheld Drager pump attached to the Drager tube which was inserted into the plastic container's hole and the pump was manually engaged 10 times. The readings were then recorded. Regardless of whether a reading of ppm ammonia was made each day on the samples' containers, each container was opened and fanned to insure that the reading of ammonia build up was for a 24 hour cycle. The results of test are in the Chart 10 below which provides the data for graph listed as “FIG. 8”:

CHART 10 Ammonia Generated (ppm) DCD-Formaldehyde oligoner versus DCD only Days Sample 7 11 14 18 21 25 28 32 ID (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) (ppm) DCD/30% 100 210 510 800 690 300 200 100 Example 50 200 600 860 620 550 480 330 75/30% urea 45 60 100 275 500 490 330 170

Example 75 is DCD-formaldehyde oligomer without the addition of free DCD. The composition of the reactants in example 75 is 2.2:1 molar ratio of DCD to formaldehyde. That molar ratio would lead one would expect some level of unreacted DCD to be present. While both DCD and Example 75 performed equivalently, at 25 days, the DCD performance drops off more substantially versus Example 75. The results show that the DCD-formaldehyde oligomers do have improved longevity versus DCD only.

Example 116

Analysis of the Dicyandiamide-Formaldehyde Reaction Products Utilizing DMSO as the NAPAOL by FTIR.

The reaction of formaldehyde with the amine groups of dicyandiamide results in a simple composition when the molar ratio of DCD to formaldehyde is 1.2:1 to 4.0:1. Under reaction parameters established in preparation of many of the examples yield a final product that contains DCD-formaldehyde adducts, unreacted DCD, DMSO and a trace of formaldehyde (<200 ppm).

The DCD-formaldehyde adduct is DCD units crosslinked through a methylene bridge between two DCD amine groups. (2)DCD-NH₂+(1)CH₂O→DCD-HN—CH2-NH-DCD+H₂O

Although there is no major function group changes during the reaction, there is a modification of the amine groups and the introduction of N—CH₂—N group. Regions of interest are 3500-3100 cm⁻¹ (primary amine stretching and secondary amine stretching) and 1130 cm⁻¹ (N—CH₂—N vibration).

Chart 11 list the examples and their molar ratios of DCD to formaldehyde

CHART 11 Molar ratio of DCD to FIG. # FTIR Scan ID Formaldehyde #5 DCD NA #2 Example 76 3.5:1 #3 Example 74 2.2:1 #4 Example 79 1.2:1

Examination of the FTIRs in FIGS. 2-4 shows the deformation of the peaks in the region of 3400-3100 cm⁻¹ (N—H stretching) as changes in the molar ratios increases the weight percent of formaldehyde in the reaction resulting in the conversion of more primary amine to secondary amines.

-   -   In examination of FIG. 5 (DCD), there is no peak in the         1130-1135 cm-1 region. FIG. 2 (Example 76) shows a small peak at         1132 cm-1. The peak at 1132 cm-1 (N—C—N stretching) becomes more         pronounced as the weight % of methylene bridges increases due to         the increase in the weight percent of formaldehyde in the         reaction. The examination of the peak at 1130-1135 cm-1 in FIG.         4 shows a more intensity versus FIG. 2

Comparing FIG. 5(DCD) to FIG. 2-4 shows that the DCD has been modified and that a DCD-formaldehyde oligomer/polymer has been formed.

-   -   The presence of water degrades the available cyano groups. It         should be clear that there are advantages to the instant         invention when the reactions are performed in the absence of         water. Using an aqueous medium limits applications to systems or         processes not negatively impacted by the presence of water. The         present invention has the advantage of not requiring other         formaldehyde reactive constituents such urea and ammonia which         are needed to impart water solubility to assist with the         dicyandiamide (DCD) since DCD has a limited solubility in water         of approximately 32 grams/liter at 20° C. The low DCD amounts in         aqueous solution result in slower reactivity and low         concentrations of the resulting polymers and oligomers.         Performing the reaction in the absence of water does not         generate the side products that result from the comparable         reactions that are done in the presence of water. This is         because when the reactions are performed in the absence of         water, the additional components that are necessary when the         reaction is performed in water are not present. For example,         when the reaction is done in water with urea and ammonia, the         resulting composition of the reaction product is a mixture of         the following undesirable by-products:         triazonyl-formaldehyde-DCD adducts, a urea-formaldehyde-DCD         adduct and the desirable polymers and/or oligomers. When the         reaction is performed in the presence of water, the composition         of the formaldehyde reaction product comprises only about 0.1 to         10 wt. % of a DCD-formaldehyde-oligomer adduct based upon the         weight of the nitrification inhibitor system. In contrast, when         the reaction is performed in the absence of water, as in the         present invention, much higher amounts of         DCD-formaldehyde-oligomer adduct is generated.     -   Moreover, as shown by the above examples, biologically active         agents can be added to the hydrophobic, biodegradable polymers         that have been produced within the NOSDS, dimethyl sulfoxide and         further can be added to the hydrophobic, biodegradable polymers         that have been produced within the NOSDS, dimethyl sulfoxide and         further formulated with protic and aprotic solvents to produce         products that slow the dissolution of urea into water.

Example 117

Qualitative analysis by HPLC (High Pressure Liquid Chromatography) and MS (Mass Spectroscopy) were performed on example 76 and example 78 utilizing Agilent Technologies Model 6520 QTOF for MS and Agilent Technologies Model 1200 LS for HPLC with the following parameters:

-   -   Elution method: isocratic elution with 4% ammonium acetate         buffer (1 mM) and 96% acetonitrile (ACN)     -   Flow rate: 0.5 ml per minute     -   Time: 5 minutes     -   Injection: 1 μL     -   Column: HILIC Acquity BEH Amide column (2.1×50 mm, 1,7μ)

FIG. 11 shows the chromatograph of example 78 while FIG. 12 shows the MS of the peaks in the chromatograph of example 78. The protonated molecule of DCD with a m/z 85.051 and the sodiated adduct of DCD with an m/z 107.033 were observed under electrospray ionization (ESI) conditions. The protonated form of the dimer (C₅H₈N₈) appears at m/z of 181.095 and a sodiated form at 203.076 and the protonated trimer (C₈H₁₂N₁₂) appears at m/z of 277.138 under ESI conditions. However, no sodium adduct was observed for the trimer. More DCD-methylol structures at m/z of 115.0867 and DCD-formaldehyde dimer-methylol structures at m/z of 211.1049 were also observed in the MS of example 78 versus example 76. Without being bound by theory, this is due to the higher ratio of formaldehyde to DCD. There are a number of unidentified small peaks within the MS, however, in ESI, different ions related to the analyte and solvent can be formed, so it is very difficult to identify all the masses in a spectrum and some peaks that relate to other molecular fragments. For example, the two m/z's at 169.0832 and at 193.0944 represent fragments from the polymer break at the methylene bridge of a tetramer. An intense response (peak) was also measured at an m/z of 124.0873. However this m/z is due to ACN, under ESI conditions, forming a trimer. The trimer show up under three peaks related to retention time of the chromatograph. This is due to the sticky nature of these compounds causing them to reside in the QTOF for some time or sticking to the walls of the tubing.

The results from qualitative analysis are summarized in Table 12.

TABLE 12 Retention and m/z Data for DCD and Samples. mass-to- Retention charge Protonated Structure DCD and Sample source time (min) ratio DCD formaldehyde structures DCD calibration 0.76 85.0513 DCD standard 0.75 107.0328 *DCD-Na Example 76 0.75 85.0513 DCD 1.42 181.0942 Dimer 2.24 181.0946 Dimer 2.24 277.1386 Trimer 2.94 277.1384 DCD Trimer 2.94 115.0867 DCD with methylol group 3.72 277.1390 Trimer Example 78 0.75 85.0513 DCD 1.43 181.0942 Dimer 1.43 115.0614 DCD with methylol group 1.43 211.1049 Dimer with methylol group 2.26 181.0945 Dimer 2.26 277.1382 Trimer 2.97 115.0866 DCD with methylol group 2.97 277.1383 Trimer 3.75 115.0865 DCD with methylol group 3.75 277.1382 Trimer *DCD-Na is not a protonated structure but a sodiated structure

TABLE 13 DAD peak areas from DAD and Mass Spec Sample Molecule DCD Monomer DCD Dimer DCD Trimer Example 76 (Coded 17K13) 17K13 m/z 85.0513 107.0327 181.0942 203.0764 277.1386 277.1384 277.139 EIC 7584378 785355 4275011 1518747 434659 2241808 1291096 Area EIC Sum 8369733 5793758 3967563 % Area 46.16% 31.95% 21.88% sum Example 78 (Coded 18C14) 18C14 m/z 85.0513 107.033 181.0942 203.0766 277.1386 277.1384 277.139 EIC 6336128 744701 3469611 714232 306897 1237643 1191386 Area EIC Sum 7080829 4183843 2735926 % Area 50.58% 29.88% 19.54% sum

EIC (Extracted Ion Chromatogram) was obtained by extracting the Total Ion

Chromatogram at a specific exact m/z value. The normalized Ratio of DCD, Dimer and Trimer is obtained by dividing the area of the individual components by the sum of those three components and multiplying the product by 100 as in the below Equation: Normalized Ratio of DCD =100*(Area DCD/(Area DCD+Area Dimer+Area Trimer)

Because of the limits of the MS that was utilized, all other DCD/formaldehyde oligomers with polymer/molecular weights greater than 300 will not generate an m/z measurement.

Example 118

41.72 grams of Example 73 were blended with 75 grams of a polysuccinimide-(PSI) (polymer weight 3000-5000 grams/mole) and 100 grams of DMSO at 60° C. and mix until the PSI had dissolved The example was cooled and package. Sample appearance was red and clear.

Example 119

35 grams of a polysuccinimide-(PSI) (polymer weight 3000-5000 grams/mole) neutralized with ammonia in 35 grams of DMSO was added to Example 73 and mixed until homogeneous. The sample was clear and red in color.

Example 120

14 grams of a low moisture dipotassium zinc ethylene diamine tetraacetate dispersed in ethylene glycol wherein the dipotassium zinc ethylene diamine tetraacetate weight percent was 47% was added to Example 78 that be heated to 40 C, mixed until homogeneous, cooled and packaged. The appearance was clear with a slight haze. (Note the Example 78 had a slight haze). This example contains 1% elemental zinc.

Example 121

55 grams of DMSO and 40 grams of Example 119 and 5 grams of N-(n-butyl) thiophosphoric triamide were mixed at 40 C until homogeneous, cooled and then packaged, Appearance was clear and the color was red.

Example 122

10 grams of a (hexylaminomethylene, aminomethylene) phosphinic acid (C₈H₂₀N₂O₂P) potassium salt dispersed in ethylene glycol was added to example 119, mix at 40 C until homogeneous, cooled and then packaged. Appearance was clear and the color was red.

Example 123

501.86 grams of DMSO and 412.44 grams of DCD were charged to a reaction flask and then heated to 81.6° C. and held at 80-85° C. for 0.5 hour and then cooled to 55° C. 17.82 grams of paraformaldehyde was slowly charged and mixed for 0.25 hour and then an inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. The contents were then heated to 70° C. and held at 70° C. over a 5 hour period of time. At 70° C., 5.77 grams of methane sulfonic acid/70% was very slowly added, mixed for 0.25 hour and then the contents were placed under a vacuum of 16-30 mm Hg. The contents were then heated to 80° C. and held for a period of 1 hour at 80-85° C. under a vacuum of 16-30 mm Hg. The contents were then heated to 90 C and held for a period of 1 hour at 90-95° C. and under a vacuum of 16-30 mm Hg. The contents were then heated to 110 C and held for a period of 0.5 hour at 105-110° C. and under a vacuum of 40-60 mm Hg. The vacuum was broken by nitrogen, the contents were cooled to 90° C. and 6.27 grams of triethanolamine/99% were charge and the contents were cooled below 45° C. and packaged. The amount of distillate collected was 87.01 grams, the yield was 896.89 grams and the calculated amount of DCD was 45.99%.

Example 124

Charge 173.42 grams of Example 123 and adjust pH (10%) to 9.5-10.5 with KOH/45%. Charge 26.58 grams of Paraformaldehyde. An inert vessel was achieved by pulling a vacuum then breaking with nitrogen and repeating this procedure 2 times. Heat contents of vessel to 70° C. and hold for 6 hours. Heat contents to 90° C. and held for 30 minutes. Cool contents to <40° C. Product was clear to slightly hazy in appearance with a strong formaldehyde odor.

10 grams of the product was charged to 190 grams of molten urea under an ammonia gas atmosphere in a reaction vessel at 140° C. The contents were agitated for 5 minutes and then poured off into an aluminum pan and flaked. The flakes were cooled and packaged.

Example 125

166.24 grams of Example 123 and 33.76 grams of Tetramethoxy glycoluril were charge to a reaction flask. The contents were heat to 80-85° C. and held at for 1 hour. Contents were cooled to <40° C. and packaged.

Example 126

752.79 grams of DMSO and 618.66 grams of DCD were charged to a reaction flask and then heated to 60-65° C. under strong agitation and mixed for 0.25 hour. 88.10 grams of paraformaldehyde was charged in 4 shots of 22.1 grams over a 1 hour period while holding temperature at 60-80° C. and then mixed for 0.5 hour and mixed for 0.25 hour. The contents were then heated to 65-75° C. and held at 65-75° C. over a 6 hour period of time. Contents were then cooled to 40-50° C. and then 8.66 grams of methane sulfonic acid/70% was very slowly added and mixed for 0.25 hour. Contents were placed under a vacuum of 16-30 mm Hg and then heated to 80° C. and held for a period of 1 hour at 80-85° C. under a vacuum of 16-30 mm Hg. The contents were then heated to 90 C and held for a period of 1 hour at 90-95° C. and under a vacuum of 16-30 mm Hg. The contents were then heated to 110 C and held for a period of 0.5 hour at 105-110° C. and under a vacuum of 40-60 mm Hg. The vacuum was broken by nitrogen, the contents were cooled to 90° C. and 9.41 grams of triethanolamine/99% were charge and the contents were cooled below 45° C. and packaged. The amount of distillate collected was 154.17 grams, the yield was 1318.11 grams and the calculated amount of DCD was 46.94%.

Example 127

272.05 grams of DMSO and 149.22 grams of DCD were charged to a reaction flask and then heated to 60-65° C. under strong agitation and mixed for 0.25 hour. 21.32 grams of paraformaldehyde was charged in 4 shots of 5.53 grams over a 1 hour period while holding temperature at 60-80° C. and then mixed for 0.5 hour. The contents were then heated to 65-75° C. and held at 65-75° C. over a 6 hour period of time. Contents were then cooled to 40-50° C. and then 8.66 grams of methane sulfonic acid/70% was very slowly added and mixed for 0.25 hour. Contents were placed under a vacuum of 16-30 mm Hg and then heated to 80° C. and held for a period of 1 hour at 80-85° C. under a vacuum of 16-30 mm Hg. The contents were then heated to 90° C. and held for a period of 1 hour at 90-95° C. and under a vacuum of 16-30 mm Hg. The contents were then heated to 110° C. and held for a period of 0.5 hour at 105-110° C. and under a vacuum of 40-60 mm Hg. The vacuum was broken by nitrogen, the contents were cooled to 90° C. and the contents were cooled below 45° C. and packaged. The amount of distillate collected was 67.72 grams, the yield was 372.65 grams and the calculated amount of DCD was 40.04%.

Example 128

400.01 grams of Example 127 and 16.52 grams of dicyandiamide were charged to a reaction flask. The contents were heated to 90-95° C. while mixing for 0.5 hour. 83.86 grams of DMSO were charged and the contents were then cooled to <45° C. and packaged. Product was clear with a slight haze and the calculated DCD content was 43.11%.

Example 129

3576.3 kgs of DMSO and 3411.3 kgs of DCD were charged to a 15,142 liter gallon 316L stainless steel reactor capable of being sealed and equipped with an overhead and a receiver for the distillate. The contents were heated to 60-65° C. under strong agitation and mixed for 0.25 hour. 348.6 kgs of paraformaldehyde was charged in 4 shots of 191.75 kgs over a 1 hour period while holding temperature at 60-80° C. Contents were mixed for 0.5 hour. The contents were then heated to 65-75° C. and held at 65-75° C. over a 6 hours period of time. Contents were then cooled to 40-50° C. and then 27.18 kgs of methane sulfonic acid/70% was very slowly added and contents were mixed for 0.25 hour. Contents were placed under a vacuum of 16-30 mm Hg and then heated to 80° C. and held for a period of 1 hour at 80-85° C. under a vacuum of 16-30 mm Hg. The contents were then heated to 90° C. and held for a period of 1 hour at 90-95° C. and under a vacuum of 16-30 mm Hg. A one liter sample was removed.

Example 130

The contents of Example 129 were then heated to 110° C. and held for a period of 0.5 hour at 105-110° C. and under a vacuum of 40-60 mm Hg. The vacuum was broken by nitrogen, the contents were cooled to 90° C. A one liter sample was removed.

Example 131

The contents of Example 130 were cooled to 60° C. and 124.6 grams of ammonium hydroxide/26% Be were slowly charged and then 1837.8 kgs of a 23.3% solution of a polysuccinimide (MWt: 3000-5000) were charged and completely dispersed. Approximately 45 kgs of ammonia gas were sparged sub-surface of the contents to adjust pH to 8.5-10.0 the contents were cooled below 45° C. and packaged.

Example 132

89.85 grams of Example 129 were charged into a reaction vessel and heated with high agitation to 90° C. Approximately 9 grams of ammonia gas was slowly sparged below the surface of the contents. The contents were heated to 110° C. and held for 0.5 hour. Contents were cooled to 90° C. and under a vacuum of 16-30 mm Hg was established and held until distillation slowed. The batch was cooled to <40° C., the vacuum was broken with nitrogen and the contents were packaged.

Example 133

Approximately 22.7 kgs of screened urea at approximately 0.6 mm in diameter was used as a seed material for the trial. The seed material was loaded into a drum using the recycle feed system. The recycle ratio was set to 3:1. Therefore, the recycle feeder was calibrated to 102.3 kgs/hr (1.7 kgs/min). A prilled urea was fed to the melter and the feeder was calibrated to 34.1 kgs/hr (0.57 kg/min). A peristaltic pump was used to meter Example 78 into the melt pot at a 0.34 kg/hr of urease inhibitor. The molten urea and Example 78 were sprayed at approximately 34.1 kgs/hr onto the falling curtain of material inside the drum. The spray was accomplished using two spraying nozzles with 100 mesh screens with an approximate pressure of 17.2 bar. The bed temperature during operation was 70-75° C. After exiting the drum, the material fell onto a vibratory screener which separated the undersized (<2 mm), product sized (2-4 mm), and the oversized material (>4 mm). The product sized material was retained. The calculated amount of Example 78 in the urea was 1.8%

Example 134

Approximately 22.7 kgs of screened urea at approximately 0.6 mm in diameter was used as a seed material for the trial. The seed material was loaded into a drum using the recycle feed system. The recycle ratio was set to 3:1. Therefore, the recycle feeder was calibrated to 102.3 kgs/hr (1.7 kgs/min). A prilled urea was fed to the melter and the feeder was calibrated to 34.1 kgs/hr (0.57 kg/min). A peristaltic pump was used to meter Example 76 into the melt pot. The urease inhibitor pump was calibrated to deliver 0.034 kg/hr of urease inhibitor. The molten urea and Example 76 were sprayed at approximately 34.1 kgs/hr onto the falling curtain of material inside the drum. The spray was accomplished using two spraying nozzles with 100 mesh screens with an approximate pressure of 17.2 bar. The bed temperature was 90-95° C. After exiting the drum, the material fell onto a vibratory screener which separated the undersized (<2 mm), product sized (2-4 mm), and the oversized material (>4 mm). The product sized material was retained. The calculated amount of Example 76 in the urea was 1.6%.

Example 135

Qualitative analysis by HPLC (High Pressure Liquid Chromatography) and MS (Mass Spectroscopy) were performed on Examples 126, 127, 129, and 130 (Table 14) and Examples 124, 128, 132, and 133 (Table 15) utilizing Agilent Technologies Model 6520 QTOF for MS and Agilent Technologies Model 1200 LS for HPLC with the following parameters:

-   -   Elution method: isocratic elution with 4% ammonium acetate         buffer (1 mM) and 96% acetonitrile (ACN)     -   Flow rate: 0.5 ml per minute     -   Time: 5 minutes     -   Injection: 1 μL     -   Column: HILIC Acquity BEH Amide column (2.1×50 mm, 1,7μ)

EIC (Extracted Ion Chromatogram) was obtained by extracting the Total Ion

Chromatogram at a specific exact m/z value. The normalized Ratio of DCD, Dimer and Trimer are obtained by dividing the area of the individual components by the sum of those three components and multiplying the product by 100 as in the below Equation: Normalized Ratio of DCD =100*(Area DCD/(Area DCD+Area Dimer+Area Trimer)

Because of the limits of the MS that was utilized, all other DCD/formaldehyde oligomers with polymer/molecular weights greater than 300 will not generate an m/z measurement.

TABLE 14 Table 14 Analysis M/z Area Percent Ratios of Examples. Ret. M/z for H Time Example Example Example Example and Na (min.) Structure 129 130 126 127 85.0510, 0.649 DCD 24.38% 26.40%  24.14%  24.68%  107.0330 115.0620, 0.720 DCD-CH₂OH 19.35% 11.50%  12.58%  15.62%  137.0440 114.078, 1.006 DCD-CH₂NH₂  0.00% 0.00% 0.00% 0.00% 136.0599 181.0950, 0.886 DCDCH₂DCD 25.48% 35.99%  34.61%  28.43%  203.0770 211.1060, 0.933 Dimer-CH₂OH and DCD- 15.53% 3.58% 4.60% 8.68% 233.0870 CH₂OCH₂-DCD 277.1390, DCDCH2DCDCH2DCD 11.81% 17.09%  18.35%  15.79%  299.1210 305.1330, Trimer CH₂OH and DCD-  0.00% 0.00% 0.00% 0.00% 327.1150 CH₂OCH₂-DCDCH₂DCD 373.1820, 1.751 Tetramer  2.69% 4.84% 5.15% 5.81% 395.1640 403.1930, 2.095 Tetramer CH₂OH and  0.75% 0.60% 0.56% 0.99% 425.1750 DCDCH₂DCD-CH₂OCH₂- DCDCH₂DCD and DCD- CH₂OCH₂- DCDCH₂DCDCH₂DCD   100%  100%  100%  100%

The experimental design of Examples in Chart 14 is focused on the impact of temperature and initial DMSO/DCD ratio on three areas:

-   -   1. % unreacted DCD,     -   2. % Dimer (methylene bis DCD)     -   3. % methylol and dimethylene ether formaldehyde-DCD adducts         (reactive formaldehyde-DCD adducts).

Examples 129 and 130 are samples taken from an industrially produced material where the process was sampled at different stages of the overall process. Example 129 represents material exposed to a max temperature of 90° C. while Example 130 represents material exposed to a max temperature 110° C. The comparison of the area percent ratios (APRs) from the HPLC/Mass Spec data shows:

-   -   1. higher temperature increased slightly the % unreacted DCD,     -   2. higher temperature strongly increased the % formaldehyde-DCD         adducts,     -   3. higher temperature strongly decreased the % methylol and         dimethylene ether formaldehyde-DCD adducts.

It is theorized that the slight increase in % unreacted DCD is related to the higher percent conversion to species of formaldehyde-DCD adducts that are higher molecular weights than a tetramer impacting the area relationships of the various structures and not due to the degradation of the methylene bridges between the DCD units. The conclusion is that the % of reactive formaldehyde-DCD adducts can be controlled by temperature but not totally eliminated under the reaction conditions of the Examples. Not to be bound by theory, it is believed that continued reaction at 110° C. can reduce the % reactive formaldehyde-DCD adducts but also could result in the loss of more cyano function.

Examples 130, 126 and 127 were at different DMSO/DCD ratios and were subjected to similar reaction conditions. The DMSO/DCD ratios were calculated to be:

-   -   Example 126: 54.9/45.1     -   Example 127: 64.6/35.4     -   Example 129: 51.2/48.8

Utilizing ratios of higher % DMSO versus DCD did show a slight increase in the conversion of unreacted DCD to formaldehyde-DCD adducts and an increase in the percentages of reactive formaldehyde-DCD adducts.

Table 15 Analysis

Table 15 shows the analytical results of contacting a liquid containing formaldehyde-DCD adducts with methylol and dimethylene ether functionalities with a fertilizer nitrogen source. Examples 133 and 124 were examples where the nitrogen source was urea while the nitrogen source for Example 132 is ammonia gas. The focus of the HPLC/Mass Spec was on those major structures associated with reaction between the nitrogen source and formaldehyde-DCD adducts with methylol and dimethylene ether functionalities:

-   -   1. DCD CH₂OH,     -   2. DCDCH₂NH₂,     -   3. DCD-CH₂— Urea.

TABLE 15 M/z Area Percent Ratios of Examples. M/z for H Example Example Example and Na Structure 133 124 132 85.0510, DCD unreacted 41.74% 42.71% 46.79% 107.0330, 115.0620, DCD CH₂OH  0.00%  0.00% 0.00% 137.0440 114.078, DCDCH₂NH₂  0.00%  0.00% 0.63% 136.0599 157.0840, DCDCH₂-Urea 16.19% 31.68% 0.00% 179.0660 181.0950, DCD Dimer 42.07% 25.61% 52.58% 203.0770, totals   100%   100% 100.00%

An examination of the APRs shows no residual DCD-CH₂OH on any of the analyzed samples indicating that this structure was consumed in reactions with urea or ammonia. The appearance of the DCDCH₂NH₂ is further confirmation that a portion of the DCD CH₂OH structure was aminated for Example 132. The other point of interest for Example 132 is that it no longer possesses the reactive capability to form a DCDCH₂-Urea structure.

Based on the APR in Table 15, Examples 133 and 124 have shown the reactive capability to form DCDCH₂-Urea structures by blending liquids containing formaldehyde-DCD adducts containing methylol and dimethylene ether functionalities into molten urea. Example 124 demonstrates that formaldehyde-DCD adducts containing higher amounts of methylol and dimethylene ether functionalities results in conversion to a higher percentage of DCDCH₂-Urea.

Example 136

272.05 grams of DMSO and 149.22 grams of DCD were charged to a reaction flask and then heated to 60-65° C. under strong agitation and mixed for 0.25 hour. 26.65 grams of paraformaldehyde was charged in 5 shots of 5.33 grams over a 1 hour period while holding temperature at 60-80° C. and then mixed for 0.5 hour. The contents were then heated to 65-75° C. and held at 65-75° C. over a 6 hour period of time. Contents were then cooled to 40-50° C. and 10% pH was adjusted to 10.8 with KOH/flakes and mixed for 0.25 hour. Contents were placed under a vacuum of 16-30 mm Hg and then heated to 80° C. and held for a period of 1 hour at 80-85° C. under a vacuum of 16-30 mm Hg. The contents were then heated to 90° C. and held for a period of 1 hour at 90-95° C. and under a vacuum of 16-30 mm Hg. The contents were cooled below 45° C. and packaged. The amount of distillate collected was 25.91 grams, the yield was 404.21 grams, and the calculated amount of DCD was 36.92% and the residual formaldehyde were below the methods detection limits of ≤100 ppm.

-   -   In an embodiment, the NOSDS not only provides the solvating         property for the hydrophobic, biodegradable polymer but also         serves as the delivery system for the hydrophobic, biodegradable         polymers to the surface of fertilizer granules. In a variation,         the NOSDS provides solvating properties to one of more         biologically active agents selected from the group consisting of         urease inhibitors, nitrification inhibitor(s), pesticide(s),         herbicide(s), fungicides(s), and insecticide(s).     -   In an embodiment, incorporating within the NOSDS one of more         biologically active agents selected from the group consisting of         urease inhibitors, nitrification inhibitor(s), pesticide(s),         herbicide(s), fungicides(s), and insecticide(s) with the         biodegradable, hydrophobic polymers that are the reaction         product of aldehyde(s) and nitrogen containing compounds will         result in lower dissolution of these biologically active agents         that are encapsulated within the hydrophobic film thereby         improving performance by increasing the length of time these         biologically active agents are available.     -   In an embodiment, the composition of the biodegradable,         hydrophobic polymers that are the reaction product of         aldehyde(s) and nitrogen containing compounds dispersed within a         NOSDS can further comprise one or more urease inhibitors         selected from the group consisting of aliphatic phosphoric         triamide, phosphoramides and N-alkyl thiophosphoric triamides,         (aminomethyl)phosphinic acids and their salts and aminomethyl         (alkylaminomethyl)phosphinic acids and their salts. In a         variation the urease inhibitor is N-(n-butyl) thiophosphoric         triamide.     -   In an embodiment, the composition of the biodegradable,         hydrophobic polymers that are the reaction product of         aldehyde(s) and nitrogen containing compounds dispersed within a         NOSDS can further comprise one or more nitrification inhibitors         selected from the group consisting of         2-chloro-6-trichloromethyl)pyridine,         4-amino-1,2,4-6-triazole-HCl,         2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide         (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium         thiosulfate, dimethylpyrazole organic and inorganic salts and         2-amino-4-chloro-6-methylpyrimidine In a variation the         nitrification inhibitor is dicyandiamide.     -   In an embodiment the composition of the biodegradable,         hydrophobic polymers that are the reaction product of         aldehyde(s) and nitrogen containing compounds dispersed within a         NOSDS can further comprise one or more nitrification inhibitors         selected from the group consisting of         2-chloro-6-trichloromethyl)pyridine,         4-amino-1,2,4-6-triazole-HCl,         2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide         (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium         thiosulfate, dimethylpyrazole organic and inorganic salts and         2-amino-4-chloro-6-methylpyrimidine and one or more urease         inhibitors selected from the group consisting of aliphatic         phosphoric triamide, phosphoramides and N-alkyl thiophosphoric         triamides, (aminomethyl)phosphinic acids and their salts and         aminomethyl (alkylaminomethyl) phosphinic acids and their salts.     -   In an embodiment, one can coat a granule of treated urea with         the biodegradable, hydrophobic polymers that are the reaction         product of aldehyde(s) and nitrogen containing compounds         dispersed within a NOSDS. Treated urea is defined as a urea         composition comprising urea and a biologically active agent         added either through a coating application or added to the urea         during the urea production process either in the melt portion or         deposited to the urea during the formation of the urea granule         when the urea is still hot. In a variation, the treated urea can         be mixed with other fertilizer components and then coated with         the biodegradable, hydrophobic polymers that are the reaction         product of aldehyde(s) and nitrogen containing compounds. This         will impart slower dissolution of these fertilizer components         and urea into water because they have been encapsulated within         the hydrophobic film, thereby improving performance by         increasing the length of time the fertilizer is available.     -   In one embodiment, the composition of the liquid formulation         comprises one or more biodegradable, hydrophobic polymers that         are the reaction product of aldehyde(s) and nitrogen containing         compounds and NOSDS. This composition is used to coat a dry         granular urea, which is then applied to cropland and turf. The         hydrophobic coating makes the urea more effective in providing         nutrients for plant growth over an extended period of time. In a         variation, the composition of the liquid formulation comprising         urea and the biodegradable, hydrophobic polymers that are the         reaction product of aldehyde(s) and nitrogen containing         compounds and NOSDS further comprise one of more biologically         active agents selected from the group consisting of urease         inhibitors, nitrification inhibitor(s), pesticide(s),         herbicide(s), fungicides(s), and insecticide(s) which when         applied to cropland and turf makes the urea more effective in         providing nutrients for plant growth over an extended period of         time.     -   In an embodiment, biodegradable, hydrophobic polymers that are         the reaction product of aldehyde(s) and nitrogen containing         compounds can be produced by reacting the aldehyde(s) with the         nitrogen containing compounds within the NOSDS. In a variation,         the NOSDS comprises dimethyl sulfoxide.     -   In an embodiment, dicyandiamide can be dispersed within dimethyl         sulfoxide and then reacted with paraformaldehyde in a molar         ratio of 3-4 moles of dicyandiamide to one reactive unit of         paraformaldehyde. This results in a composition comprised of         dicyandiamide, that has reacted as well as some unreacted         dicyandiamide. The composition unexpectedly contains DCD that is         present at 35-60% by weight that will survive 3 freeze/thaw         cycles (that is, the DCD does not crash out of solution). This         is an unexpected result since the compositional percentage of         dicyandiamide in a solution with dimethyl sulfoxide at a         temperature of less than 35° C. was thought to not be able to         exceed 35% by weight. In a variation, such a composition can         also be applied to urea as a nitrification inhibitor providing         extended nitrification inhibition due to the slow release of DCD         into a plant growth media. In another variation, the composition         can be added to an anhydrous ammonia formulation for sub-surface         applications by injection of the anhydrous ammonia formula         directly into the soil.     -   In an embodiment, the composition of the active hydrophobic         coating agent comprises 5-60% of the biodegradable, hydrophobic         polymers that are the reaction product of aldehyde(s) and         nitrogen containing compounds and 95-40% of NOSDS. In a         variation, the composition can further comprise 1 to 45% of         biologically active agents.     -   In an embodiment, the method to make biodegradable, hydrophobic         polymers that are the reaction product of aldehyde(s) and         nitrogen containing compounds is a) dissolve the nitrogen         containing compounds in an aprotic solvent at temperatures in         the range of 30-110° C., then cool to 40-60° C. and insure that         pH is in the range of 8-10, b) slowly add the aldehyde and allow         the exotherm to be controlled either through charge rate or         removing the heat of reaction through a cooling median, c)         slowly heat the composition to 70-90° C. and hold for a period         of time, d) cool the composition to 40-70° C., and slowly charge         enough of an acid catalyst to drop the pH to 5-6.5 and let mix         for an extended period of time to control the exotherm, e)         slowly heat the composition to 90-115° C., f) after holding for         a period of time, one can elect to place the batch under a         vacuum to assist in removing water by-products, driving the         reaction to more completion and removing any unreacted aldehyde         and then cooling the batch. In a variation, one can charge         protic and aprotic solvents to improve flow properties and         storage stability. In another variation, one can charge a low         molecular weight alcohol to improve and control the reaction.         One can also cap unreacted methylene hydroxides through charging         low molecular weight alcohols.     -   In an embodiment the % composition of the biodegradable,         hydrophobic polymers that are the reaction product of         aldehyde(s) and nitrogen containing compounds is         stoichiometrically set to insure that there is no free         formaldehyde or unreacted methylol groups remaining in the final         product. In a variation, residual methylol groups can be capped         by the addition of a low molecular weight alcohol such as but         not limited to methanol, ethanol, propanol and butanol. In         another variation, due to the penetration of urea by dimethyl         sulfoxide, the alcohol capped methylol groups can be further         reacted onto and with the surface of the urea utilizing         temperature and catalysts known to those skilled in the art of         reacting alcohol capped methylol groups, further improving the         hydrophobic properties of the coating.     -   In an embodiment, the minimum application level of the liquid         composition (of the biodegradable, hydrophobic polymers) is 3         quarts applied to one ton of urea. This mix provides extended         time for plants to receive the nutrients from the treated         fertilizer. In a variation, the liquid composition that is         applied at a level of 3 quarts/ton of urea further comprises         biologically active agents.     -   In an embodiment, the liquid composition of the biodegradable,         hydrophobic polymers that are the reaction product of         aldehyde(s) and nitrogen containing compounds dispersed within a         NOSDS can further comprise monomers such as but not limited to         tetramethoxy glycoluril or hexamethoxymethylmelamine. These         additional monomers impart further crosslinking of the polymer         to the surface of urea due to the penetration of urea by         dimethyl sulfoxide. In a variation, Example 18 is a ready to use         crosslinker dispersed in dimethyl sulfoxide that can be readily         incorporated into the liquid composition.     -   In an embodiment, the water resistance of fertilizer coated with         the liquid composition of the biodegradable, hydrophobic         polymers that are the reaction product of aldehyde(s) and         nitrogen containing compounds dispersed within a NOSDS can         improve with time and with heat.     -   In an embodiment, a water resistant fertilizer is comprised of         urea and the liquid composition of the biodegradable,         hydrophobic polymers that are the reaction product of         aldehyde(s) and nitrogen containing compounds dispersed within a         NOSDS. In a variation the water resistant fertilizer is further         comprised of one or more biologically active agents selected         from the group consisting of urease inhibitors, nitrification         inhibitor(s), pesticide(s), herbicide(s), fungicides(s),         insecticide(s), flow modifiers and methylol capped monomers that         are the reaction product of aldehyde(s) and nitrogen containing         compounds. In a variation the flow modifier is a hydrophobic         silica. In another variation, the one or more methylol capped         monomers that are the reaction product of aldehyde(s) and         nitrogen containing compounds are selected from the group         consisting of tetramethoxy glycoluril, Tetra(methoxymethyl)         urea, di(methoxymethyl) urea and hexamethoxymethylmelamine.     -   In an embodiment, the present invention relates to a composition         comprising one or more biodegradable hydrophobic polymers of a         molecular weight range of 50-200,000 Daltons and a Non-aqueous         Organo Solvent Delivery System (NOSDS), wherein said composition         is a stable dispersion ideally suited to coat man-made and/or         natural fertilizer components, wherein the biodegradable,         hydrophobic polymers comprise the reaction products of         aldehyde(s) and nitrogen containing compounds and wherein the         NOSDS is comprised of a) one or more protic solvents selected         from the group consisting of: 1) an alcohol from the family of         C₁₋₁₀ alkanols, 2) one or more polyols selected from the group         consisting of trimethylol propane, trimethylol ethane,         pentaerythritol, sorbitol, sorbitan, glucose, fructose,         galactose, and glycerin, 3) one or more poly(C₁₋₁₀ alkylene)         glycols represented by the structure:         H(C_(t)H_(u))_(v)OH     -   t is an integer: 1-10     -   u is an integer: 2-20     -   and v is an integer: 1-20,     -   4) one or more alkylene glycols selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, and butylene glycol, 5) isopropylidene         glycerol 6) one or more alkylene glycol alkyl ethers selected         from the group represented by the structure:

-   -   -   Where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉         -   Where R² is: H or the structure

-   -   -   where R³ is: H or CH₃         -   where R⁴ is H and CH₃         -   and f is an integer between 1 and 15

    -   7) one or more alkyl lactates selected from the group consisting         of ethyl, propyl and butyl lactate, 8) one or more alkanolamines         selected from the group represented by the structure:

-   -   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH         -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁸ is: (C₂H₄O)_(g)H         -   and g is an integer between 1-10

    -   and 9) glycerol carbonate,         b) and one or more aprotic solvents selected from the group         consisting of 1) dimethyl sulfoxide and 2) dialkyl, diaryl, or         alkylaryl sulfoxide(s) having the formula:         R₉S(O)_(x)R₁₀

    -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or

    -   C₁₋₃ alkylenearyl group, or R₉ and R₁₀ with the sulfur to which         they are attached form a 4 to 8 membered ring wherein R₉ and R₁₀         together are a C₁₋₆ alkylene group which optionally contains one         or more atoms selected from the group consisting of O, S, Se,         Te, N, and P in the ring and x is 1 or 2,

    -   3) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, 4) one or more polyols capped with acetate         or formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 5) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and tripropylene         glycol butyl ether acetate and, 6) isophorone, 7) one or more         diesters selected from the group consisting of         dimethylsuccinate, dimethyl adipate, diethyl glutarate, and         dimethyl glutarate, 8) dimethylacetamide, 9)         dimethylformamide, 10) dimethyl-2-imidazolidinone, 11)         1-Methyl-2-pyrrolidone, 12) hexamethylphosphoramide, 13)         1,2-dimethyloxyethane, 14) 2-methoxyethyl ether,         15)cyclohexylpyrrolidone and 16) limonene.

    -   In an embodiment, the aldehyde(s) portion of biodegradable,         hydrophobic polymers resulting from the reaction products of         aldehyde(s) and nitrogen containing compounds comprise one or         more aldehyde(s) selected from the group represented by the         structure:         a)

-   -   where Q is: O, S     -   where R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —CH═CH₂,         —C₄H₃O, —C₇H₇, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O, C₃H₅O, C₄H₇O, C₇H₅O or         —R¹²O₂R¹³,     -   where R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₈, —C₆H₁₀     -   where R¹³ is: —H, CH₃, C₂H₃, C₃₁₁₇, C₄H₉.     -   In an embodiment, the nitrogen containing compounds portion of         biodegradable, hydrophobic polymers resulting from the reaction         products of aldehyde(s) and nitrogen containing compounds         comprise one or more nitrogen containing compounds selected from         the group represented by the structures:     -   a)

-   -   -   where A is: O, S         -   where R¹⁴ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅,             —CONH₂, —(CONH)_(a) NH₂         -   where a is an integer: 1-10         -   where R¹⁵ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅,             —CONH₂, —(CONH)_(b) NH₂         -   where b is an integer: 1-10         -   where R¹⁶ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅,             —CONH₂, —(CONH)_(c) NH₂         -   where c is an integer: 1-10         -   where R¹⁷ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅,             —CONH₂, —(CONH)_(d) NH₂         -   where d is an integer: 1-10,

    -   b)

-   -   -   and their tautomeric forms,

    -   c)

-   -   -   where X₁ is: —NHR¹⁸, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃         -   where R¹⁸ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅,             —C₂H₄OC₂H₄OH, C₂H₄OC₂H₄NH₂, C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         -   where X₂ is: —NHR¹⁹, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃         -   where R¹⁹ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅,             —C₂H₄OC₂H₄OH, C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         -   where X₃ is: —NHR²⁰, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃         -   where R²⁰ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅,             —C₂H₄OC₂H₄OH, C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅

    -   and d)         -   NH₂CO—R²¹         -   where R²¹ is an alkyl radical CH₃ to —C₁₇H₃₅.

In an embodiment, the composition of the biodegradable hydrophobic polymers comprise the reaction products of aldehyde(s) and nitrogen containing compounds which comprise one or more aldehydes selected from the group consisting of:

-   -   methanal, ethanal, propanal, butanal, pentanal, hexanal,         methylethanal, methylpropanal, methylbutanal,         phenylacetaldehyde, benzaldehyde, 2-propenal, 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid, 6-oxohexanoic acid, 2-oxopropanal,         cyclohexanal, furfural, methyl esters of 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid and 6-oxohexanoic acid, ethandial,         1,3-propanedial, butanedial, pentanedial, phthalaldehyde or         methanethial.     -   In an embodiment, the composition of the biodegradable         hydrophobic polymers comprise the reaction products of         aldehyde(s) and nitrogen containing compounds which comprise one         or more nitrogen containing compounds comprise selected from the         group consisting of:     -   urea, biuret, polyurea, thiourea, methylurea, dimethylurea,         ethylurea, diethylurea, propylurea, dipropylurea, butylurea,         dibutylurea, phenylurea, diphenyl urea, pentylurea,         dipentylurea, hexyl urea, dihexyl urea, methylthiourea,         dimethylthiourea, ethylthiourea, diethylthiourea,         propylthiourea, diporpylthiourea, butylthiourea,         dibutylthiourea, pentylthiourea, dipentylthiourea,         hexylthiourea, dihexylthiourea, phenylthiourea,         diphenylthiourea, cyanamide, dicyandiamide, tricyantriamide,         melamine, hydroxy oxypentyl melamine, methylaminomelamine,         dimethylaminopropylmelamine, 1,3,5-Triazine-2,4,6 triamine, 2,         4-diamino-1, 3, 5-triazine, 2,4-diol-6-Amino-1,3,5-triazine,         2,4-Diamino-6-hydroxy-1,3,5-triazine,         2-Butylamino-4,6-diamino-1,3,5-triazine,         2,4-Diamino-6-methyl-1,3,5-triazine,         2,4-Diamino-6-dimethylamino-1,3,5-triazine,         2-Amino-1,3,5-triazine, ethanamide, propanamide, butanamide,         pentanamide, hexanamide, heptanamide, octanamide, nonanamide,         decanamide, dodecanamide, tetradecanamide, hexadecanamide, and         octadecanamide.     -   In an embodiment, the composition of the biodegradable,         hydrophobic polymer(s) further comprises, 0.1-5.0% of the         polymer weight a) polyamines comprising of one or more members         selected from the group consisting of:     -   ethylenediamine, diethylenetriamine, triethylenetetramine     -   tetraethylenepentamine and aminoethylethanolamine,         b) one or more polyol compounds selected form the group         consisting of:     -   trimethylol propane, trimethylol ethane, pentaerythritol,         sorbitol and sorbitan, glucose, fructose, galactose, and         glycerin, poly(C₁₋₁₀ alkylene) glycols, ethylene glycol, 1,3         propylene glycol, 1,2 propylene glycol, and butylene glycol, and         c) one or more monoprotic compound(s) selected from the group         consisting of:     -   diethylamine, diethanolamine, methylethanolamine,         diisopropanolamine, methylispropylamine, cyclohexalamine,         methanol, ethanol, butanol, hexanol, isopropylidene glycerol,         tripropylene glycol methyl ether, tripropylene glycol butyl         ether, dipropylene glycol butyl ether and tripropylene glycol         butyl ether.     -   In an embodiment, the composition of the one or more         biodegradable hydrophobic polymers is present in an amount that         is between about 5-65% of a total composition.     -   In an embodiment, the composition of the biodegradable,         hydrophobic polymers which comprises the reaction products of         aldehyde(s) and nitrogen containing compounds dispersed in NOSDS         further comprises one or more of surfactants, buffers,         fragrance/odor masking agents, colorants, flow modifiers,         silicas, hydrophobized silicas, one or more biologically active         agents selected from the group consisting of a) urease         inhibitors, nitrification inhibitors, pesticides, herbicides         fungicides(s), and insecticide(s) and one or more catalysts         selected from the group consisting of methane sulfonic acid,         sulfuric acid, para-toluene sulfonic acid, phosphoric acid and         methane phosphonic acid.     -   In an embodiment, the composition of the biodegradable,         hydrophobic polymers comprise the reaction products of         aldehyde(s) and nitrogen containing compounds dispersed in NOSDS         wherein said aldehyde comprises paraformaldehyde. In an         embodiment, said nitrogen containing compounds comprise         dicyandiamide and said NOSDS is dimethyl sulfoxide. In a         variation, the composition further comprises one or more of         surfactants, buffers, fragrance/odor masking agents, colorants,         flow modifiers, silicas, hydrophobized silicas, one or more         biologically active agents selected from the group consisting         of a) urease inhibitors, nitrification inhibitors, pesticides,         herbicides fungicides(s), and insecticide(s) and one or more         catalysts selected from the group consisting of methane sulfonic         acid, sulfuric acid, para-toluene sulfonic acid, phosphoric acid         and methane phosphonic acid.     -   In an embodiment, the method of use of the composition         comprising dicyandiamide, paraformaldehyde and dimethyl         sulfoxide that provides high levels of the nitrification         inhibitor, dicyandiamide, is as a coating onto fertilizer         granules. Alternatively and/or additionally, the composition can         be added to anhydrous ammonia for direct injection into the soil         to provide extended availability of nutrients for plant growth         through inhibiting the conversion of ammonia to nitrate.     -   In an embodiment, the method for making the composition of the         biodegradable, hydrophobic polymers which comprises the reaction         products of aldehyde(s) and nitrogen containing compounds         dispersed in NOSDS for application to fertilizer comprises         adding biodegradable hydrophobic polymers that are the reaction         product of aldehydes and nitrogen containing compound powders to         the NOSDS under agitation at temperatures of 15-140° C., and         optionally using a high shear mixer to reduce viscosity of the         mixture.     -   In an embodiment, the present invention relates to a method for         making the composition of the biodegradable, hydrophobic         polymers which comprises the reaction products of aldehyde(s)         and nitrogen containing compounds dispersed in NOSDS for         application to fertilizer. In a variation, the method comprises         adding a) biodegradable hydrophobic polymers that involves the         reaction of aldehydes and nitrogen containing compound that are         pre-dispersed in a liquid with undesirable properties such as         flash point, health, shipping or environmental hazards and/or         destabilize components of fertilizer or additives to the         fertilizer to b) a NOSDS in which the liquid is displaced         through differential boiling points by temperature and/or         reduced pressure.     -   In an embodiment, the present invention relates to a method for         making the composition of the biodegradable, hydrophobic         polymers which comprises the reaction products of aldehyde(s)         and nitrogen containing compounds dispersed in NOSDS for         application to fertilizer comprised of procuring 1) one or more         aldehydes represented by the structure:         a)

-   -   where Q is: O, S     -   where R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —CH═CH₂,         —C₄H₃O, —C₇H₇, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O, C₃H₅O, C₄H₇O, C₇H₅O or         —R¹²O₂R¹³,     -   where R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₈, —C₆H₁₀     -   where R¹³ is: —H, CH₃, C₂H₃, C₃H₇, C₄H₉     -   and reacting said aldehydes with 2) one or more nitrogen         containing compounds selected from the group represented by the         structures:         a)

-   -   where A is: O, S     -   where R¹⁴ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(a) NH₂     -   where a is an integer: 1-10     -   where R¹⁵ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(b) NH₂     -   where b is an integer: 1-10     -   where R¹⁶ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(c) NH₂     -   where c is an integer: 1-10     -   where R¹⁷ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(d) NH₂     -   where d is an integer: 1-10,         b)

-   -   and their tautomeric forms,         c)

-   -   where X₁ is: —NHR¹⁸, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   where R¹⁸ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅     -   where X₂ is: —NHR¹⁹, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   where R¹⁹ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅     -   where X₃ is: —NHR²⁰, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   where R²⁰ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         and d)         NH₂CO—R²¹     -   where R²¹ is an alkyl radical CH₃ to —C₁₇H₃₅         3) dispersing the nitrogen containing compound(s) at         temperatures of 10-140° C. into a non-aqueous organo solvent         delivery system (NOSDS), wherein the NOSDS comprises one or more         aprotic solvents selected from the group consisting of 1)         dimethyl sulfoxide and 2) dialkyl, diaryl, or alkylaryl         sulfoxide(s) having the formula:         R₉S(O)_(x)R₁₀     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together         with the sulfur to which they are attached form a 4 to 8         membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene         group which optionally contains one or more atoms selected from         the group consisting of O, S, Se, Te, N, and P in the ring and x         is 1 or 2, and optionally further comprising     -   one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, 4) one or more polyols capped with acetate         or formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 5) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and tripropylene         glycol butyl ether acetate and, 6) isophorone, 7) one or more         diesters selected from the group consisting of         dimethylsuccinate, dimethyl adipate, diethyl glutarate, and         dimethyl glutarate, 8) dimethylacetamide, 9)         dimethylformamide, 10) dimethyl-2-imidazolidinone, 11)         1-Methyl-2-pyrrolidone, 12) hexamethylphosphoramide, 13)         1,2-dimethyloxyethane, 14) 2-methoxyethyl ether, 15)         cyclohexylpyrrolidone and 16) limonene,         4) wherein said composition is cooled to 30-60° C. and the         aldehydes are charged at a rate that controls the exotherm with         5-20° C. of the reaction temperature of 30-70° C. in a molar         ratio of aldehyde to aldehyde reactive sites on the nitrogen         containing compound of 0.10-0.90/1.0;         5) wherein the reaction is held at 30−70° C. and at a pH of         7.5-10.0 for 1 to 12 hours until the free formaldehyde is         40,000-5,000 ppm's; and         6) wherein the pH is adjusted to 4.0-6.5, and the reaction is         heated to 70-115° C.,         7) wherein the reactor is optionally placed under a vacuum with         a nitrogen sparge of 0.1 mm to 200 mm and held until free         formaldehyde is <700 ppm, and then the composition is cooled.     -   In an embodiment, the present invention relates to a process for         applying the composition of the biodegradable, hydrophobic         polymers said process comprising adding the reaction products of         aldehyde(s) and nitrogen containing compounds dispersed in NOSDS         to fertilizer granules. In an embodiment, the process comprises:     -   1) placing the fertilizer granules in blending equipment         comprising one or more pieces of equipment selected from the         group consisting of mixers, blenders and tumblers or on a         conveyer belt     -   2) applying the composition to said fertilizer granules at a         temperature of 15-130° C. through a metering or a spray         injection system; and     -   3) mixing or spraying until the fertilizer granules show         complete coverage.     -   In an embodiment, the present invention relates to a composition         comprising one or more biodegradable hydrophobic polymers of a         molecular weight range of 50-200,000 Daltons, a crosslinking         agent and a Non-aqueous Organo Solvent Delivery System (NOSDS),         wherein said composition is a stable dispersion ideally suited         to coat man-made and/or natural fertilizer components, wherein         the biodegradable, hydrophobic polymers comprise the reaction         products of aldehyde(s) and nitrogen containing compounds and         wherein the NOSDS is comprised of one or more aprotic solvents         selected from the group consisting of 1) Dimethyl Sulfoxide         and 2) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or     -   C₁₋₃alkylenearyl group or R₉ and R₁₀ with the sulfur to which         they are attached form a 4 to 8 membered ring wherein R₉ and R₁₀         together are a C₁₋₆ alkylene group which optionally contains one         or more atoms selected from the group consisting of O, S, Se,         Te, N, and P in the ring and x is 1 or 2,     -   and optionally further comprising         3) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate, 4) one or more polyols capped with acetate         or formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 5) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and tripropylene         glycol butyl ether acetate and, 6) isophorone, 7) one or more         diesters selected from the group consisting of         dimethylsuccinate, dimethyl adipate, diethyl glutarate, and         dimethyl glutarate, 8) dimethylacetamide, 9)         dimethylformamide, 10) dimethyl-2-imidazolidinone, 11)         1-Methyl-2-pyrrolidone, 12) hexamethylphosphoramide, 13)         1,2-dimethyloxyethane, 14) 2-methoxyethyl ether,         15)cyclohexylpyrrolidone and 16) limonene.

In a variation, the aldehyde(s) is comprised of one or more compounds represented by the structure:

-   -   where Q is: O, S     -   where R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —CH═CH₂,         —C₄H₃O, —C₇H₇, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O, C₃H₅O, C₄H₇O, C₇H₅O or         —R¹²O₂R¹³,     -   where R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₈, —C₆H₁₀     -   where R¹³ is: —H, CH₃, C₂H₃, C₃H₇, C₄H₉     -   wherein the nitrogen containing compound comprises one or more         compounds represented by the structures:

-   -   where A is: O, S     -   where R¹⁴ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(a) NH₂     -   where a is an integer: 1-10     -   where R¹⁵ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(b) NH₂     -   where b is an integer: 1-10     -   where R¹⁶ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(c) NH₂     -   where c is an integer: 1-10     -   where R¹⁷ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃, —C₆H₅, —CONH₂,         —(CONH)_(d) NH₂     -   where d is an integer: 1-10,

-   -   and their tautomeric forms,

-   -   where X₁ is: —NHR¹⁸, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   where R¹⁸ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅     -   where X₂ is: —NHR¹⁹, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   where R¹⁹ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅     -   where X₃ is: —NHR²⁰, —H, —OH, —C₆H₅, —N(CH₃)₂, —CH₃     -   where R²⁰ is: H, an alkyl radical —CH₃ to —C₁₂H₂₅, —C₂H₄OC₂H₄OH,         C₂H₄OC₂H₄NH₂, —C₃H₆—N(CH₃)₂, C₂H₄OH, —C₆H₅         -   and     -   NH₂CO—R²¹     -   where R²¹ is an alkyl radical CH₃ to —C₁₇H₃₅         wherein a crosslinking agent is comprised of one or more of         compounds represented by the structures:

-   -   In an embodiment, the present invention relates to a composition         of the biodegradable, hydrophobic polymers which comprises the         reaction products of aldehyde(s) and nitrogen containing         compounds dispersed in NOSDS wherein the one or more         biodegradable hydrophobic polymers are present in an amount that         is between about 5-65% of a total composition. In a variation,         the crosslinking agent is present in an amount that is between         about 0.1-10% of the total composition.     -   In an embodiment, the composition of the biodegradable,         hydrophobic polymers which comprises the reaction products of         aldehyde(s) and nitrogen containing compounds dispersed in         NOSDS, further comprising one or more of surfactants, buffers,         fragrance/odor masking agents, colorants, flow modifiers,         silicas, hydrophobized silicas, one or more biologically active         agents selected from the group consisting of a) urease         inhibitors, nitrification inhibitors, pesticides, herbicides         fungicides(s), and insecticide(s) and one or more catalysts         selected from the group consisting of methane sulfonic acid,         sulfuric acid, para-toluene sulfonic acid, phosphoric acid and         methane phosphonic acid.     -   In an embodiment, the present invention relates to compositions         and methods of making a liquid fertilizer additive of         biodegradable polymeric and/or oligomeric nitrification         inhibitors comprised of utilizing a non-aqueous polar, aprotic         organo liquid (NAPAOL) as the reaction medium for the reaction         of aldehyde(s) with cyano-containing nitrification inhibitors         that have one or more aldehyde reactive groups selected from the         group consisting of a) primary amines, b) secondary amines, c)         amides, d) thiols, e) hydroxyls and f) phenols, wherein one or         more of the following variants are met:     -   1. the reaction medium does not contain water as many nitrogen         source application techniques are sensitive to the presence of         moisture. The presence of water can also lead to the degradation         of the cyano-group to diaminomethylene urea under reaction         conditions,     -   2. the reaction medium must be aprotic to prevent any solvent         reaction with aldehydes,     -   3. the reacting materials and final product must be or become         soluble in the reaction medium,     -   4. the reaction does not require aldehyde reactive,         non-nitrification compounds (outside of catalyst) such as urea         or ammonia in order to facilitate the reaction of aldehyde with         a nitrification inhibitor,     -   5. the reaction medium can also serve as the solvent delivery         system for applications to nitrogen sources utilizing one or         more application techniques selected from the group consisting         of a) coating the surface of fertilizer granules/prills, b)         dispersing the liquid invention into an aqueous nitrogen source         such as UAN, c) dispersing the liquid invention into ammonical         sub-surface injections, d) aiding in dissolving the liquid         invention directly into molten nitrogen sources such as urea,     -   6. the reaction medium also serves as the solvent for         incorporating biologically active agents and naturally occurring         substances, substances produced by natural processes such as         fermentation and/or extracts of naturally occurring substances         (termed as biologics) such as but not limited one or more         members selected from the group consisting of urease inhibitors,         nitrification inhibitor(s), pesticide(s), herbicide(s),         fungicides(s), and insecticide(s),     -   7. the reaction conditions are selected which favor the         conservation of the cyano-group,     -   8. the final product is dispersed in a non-aqueous liquid,     -   9. the level of free aldehyde in the final product is less than         700 ppm.     -   In an embodiment, a method of making a liquid fertilizer         additive of biodegradable polymeric and/or oligomeric         nitrification inhibitors is comprised of utilizing NAPAOL as the         reaction medium for the reaction of aldehyde(s) with         cyano-containing nitrification inhibitors that have one or more         aldehyde reactive groups selected from the group consisting         of a) primary amines, b) secondary amines, c) amides, d)         thiols, e) hydroxyls and f) phenols wherein the resulting         product possesses one or more of the following improvements over         reactions performed in an aqueous medium:     -   1. better control over polymer distribution resulting from the         proper selection of process conditions,     -   2. lower water solubility results in slower dissolution of         nitrogen sources and added biological actives once applied to         the soil,     -   3. slow the loss of nitrification inhibition by reducing the         nitrification inhibitors' volatility, limiting migration through         the soil by increasing its molecular weight which lowers the         nitrification inhibitors' water solubility,     -   4. extending the nitrification inhibitors' lifespan by utilizing         incorporation into a polymer backbone which through         biodegradation results in a slow release of incorporated         nitrification inhibitors,     -   5. retaining some nitrification inhibition capability through         formation of methylene bis nitrification inhibitor oligomers         based on the reaction product of a total 2 moles of one or more         nitrifications inhibitors that contain 1 to 2 aldehyde reactive         groups reacted with one mole of aldehyde,     -   6. lower viscosity versus polymers formed in an aqueous medium         which aides in coating solid nitrogen sources and adding to         aqueous nitrogen sources as well as non-agricultural processes         either further chemically modified or unmodified such as but not         limited to industrial processes such as waste water color         removal, paint detackification and treatment of paint or oily         waste water and the treatment of leather,     -   7. able to maintain said biodegradable polymers at levels of         1-80% as liquids in a NAPAOL to temperatures down to at least         10° C. meaning that these compositions have improved shelf         storage lives,     -   8. able to provide improved and even delivery of the liquid         invention to the surface of fertilizer granules and solid         nitrogen sources of said biodegradable polymeric/oligomeric         nitrification inhibitors while not causing clumping of the         granules,     -   9. able to safely incorporate into non-aqueous liquid nitrogen         sources such as pressurized anhydrous ammonia gas,     -   10. able to incorporate directly into molten nitrogen sources a         non-aqueous liquid product that results in better distribution         of the said biodegradable polymeric/oligomeric nitrification         inhibitors throughout the molten mass,     -   11. able to achieve higher concentration levels of the total of         polymer bound and free nitrification inhibitors versus         non-aqueous polar aprotic organo solvated free only         nitrification inhibitors,     -   12. process yields a liquid product with an aldehyde content of         <700 ppm.

In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols results in a product for direct application to nitrogen sources.

In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols is designed wherein the molar ratio is set to ensure that the aldehyde to aldehyde reactive groups ratio available in said cyano-containing nitrification inhibitors is such that the aldehyde is completely reacted to its methylene form versus the methylol function. —NI—CH₂—NI vs —NI—CH₂—OH

In a variation, the molar ratio of said aldehyde to said cyano-containing nitrification inhibitors is set with an excess of aldehyde reactive groups to ensure low free aldehyde products.

In an embodiment, a method of making fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols wherein to conserve the cyano-function of the nitrification inhibitors, one or more of the following reaction parameters are utilized: 1) limit the presence of water throughout the reaction, 2) minimize the temperature of any acid catalyst addition, and 3) minimize reaction time and/or temperature. In an embodiment, there are two reactions that occur. A first reaction is the aldehyde reaction with the amine and other groups as shown above and the second is the reaction of the methylol group with an aldehyde reactive group (as shown above), which is a reaction that can be accomplished in one embodiment by the addition of an acid catalyst. The reaction temperature should remain below about 70° C. for the addition of acid catalyst. It should be understood that as one increases the temperature, the time can be decreased and vice versa. In an embodiment, the time may range from about 8 hours to 32 hours. In an embodiment, it should be understood that water may be removed as the second reaction proceeds to further increase yield of the reaction product.

In an embodiment, a method of making fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols comprises the following steps:

-   -   A) procurement of         -   1) one or more aldehydes represented by the structure:             -   a)

-   -   -   -   wherein Q is: O, S             -   wherein R¹¹ is: —H, alkyl radical —C₁H₃ to —C₆H₁₃,                 —CH═CH₂, —C₄H₃O, —C₇H₇, —C₆H₅, —C₆H₁₁, CHO, C₂H₃O,                 C₃H₅O, C₄H₇O, C₇H₅O or —R¹²O₂R¹³,             -   wherein R¹² is: —C, —C₂H₂, —C₃H₄, —C₄H₆, —C₅H₅, —C₆H₁₀             -   wherein R¹³ is: —H, CH₃, C₂H₃, C₃₁₁₇, and C₄H₉

        -   2) one or more cyano-containing nitrification inhibitors             that have one or more aldehyde reactive groups selected from             the group consisting of a) primary amines, b) secondary             amines, c) amides, d) thiols, e) hydroxyls and f) phenols             selected from the group consisting of:

        -   a) one or more cyano-compounds selected from the group             represented by the structures

-   -   -   3) a non-aqueous polar aprotic organo liquid, wherein the             non-aqueous polar, aprotic solvent (NAPAOL) is the reaction             medium, which comprises one or more members selected from             the group consisting of             -   a) dimethyl sulfoxide             -   b) and dialkyl, diaryl, or alkylaryl sulfoxide(s) having                 the formula:                 R₉S(O)_(x)R₁₀             -   wherein R₉ and R₁₀ are each independently a C₁₋₆                 alkylene group, an aryl group, or C₁₋₃alkylenearyl group                 or R₉ and R₁₀ together with the sulfur to which they are                 attached form a 4 to 8 membered ring wherein R₉ and R₁₀                 together are a C₁₋₆ alkylene group which optionally                 contains one or more atoms selected from the group                 consisting of O, S, Se, Te, N, and P in the ring and x                 is 1 or 2.             -   c) and one or more alkylene carbonates selected from the                 group consisting of ethylene carbonate, propylene                 carbonate and butylene carbonate d)                 1-Methyl-2-pyrrolidone, e) one or more organo                 phosphorous liquids selected from the group consisting                 of hexamethylphosphoramide and one or more                 trialkylphosphates selected from the group represented                 by the formula.

-   -   -   -   -   wherein:                 -    R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃                 -    R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃                 -    R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

            -   f) 1,2-dimethyloxyethane, g) 2-methoxyethyl ether and h)                 cyclohexylpyrrolidone

    -   B) a reaction vessel may be equipped with agitation, heating and         cooling (hot oil systems are not recommended), riser, overhead         condenser and a receiving vessel to capture reaction distillate,         capable of a vacuum of 0.5-50 mm and sparging/sweeping with an         inert gas such as but not limited to nitrogen and carbon dioxide

    -   C) charging said procured ingredients to said reactor by one or         more steps selected from the group consisting of:         -   a) charging said aldehydes, said cyano-nitrification             inhibitors and said NAPAOL to said reaction vessel and start             mixing         -   b) charging said cyano-containing nitrification inhibitors             and said NAPAOL to said reaction vessel, start mixing and             heating mixture to 40-90° C., holding for 0-60 minutes at             temperature, cooling down to 20-60° C. and then charging             said aldehyde.         -   c) charging said cyano-containing nitrification inhibitors             and said NAPAOL to said reaction vessel, de-oxygenate the             vessel by either sparging with an inert gas such as but not             limited to nitrogen and carbon dioxide for a 15-60 minutes             or by placing vessel under vacuum and breaking vacuum by             sparging/sweeping vessel with an inert gas and repeating             this exercised-oxygenation at least 3 times and then             charging said aldehyde.

    -   D) proceeding with the first reaction by one or more steps         selected from the group consisting of:         -   a) heating contents of the vessel to 50-90° C. and hold at             temperature for 1-4 hours,         -   b) heating contents of the vessel to 70-80° C. and hold at             temperature for 1-4 hours         -   c) heating contents of the vessel to 50-90 C and hold at             temperature until contents are clear         -   d) heating contents of the vessel to 70-80° C. and hold at             temperature until contents are clear.

    -   E) proceeding with the second reaction by one or more steps         selected from the group consisting of:         -   a) placing reaction vessel under a vacuum of 0.5-50 mm,             increasing temperature to 90-120° C. and held under vacuum             and at temperature until aldehyde content is 0-700 ppm.         -   b) charging an acid catalyst such as but not limited to one             or more members selected from the group consisting of             methane sulfonic acid, sulfuric acid, para-toluene sulfonic             acid phosphoric acid and methane phosphonic acid, placing             reaction vessel under a vacuum of 0.5-50 mm, increasing             temperature to 90-120° C. and hold under vacuum and at             temperature until aldehyde content is 0-700 ppm. In a             variation, cooling contents of reaction vessel, if             necessary, to 20-60° C. before charging the acid catalyst

    -   F) terminating the reaction by one or more steps selected from         the group consisting of:         -   a) hard sparging reaction vessel contents with an inert gas             to assist in removing residual aldehyde. Vacuum and hard             sparge can be repeated to assist in removing aldehyde from             the contents in the reaction vessel.         -   b) Ensuring ppm formaldehyde is <700 ppm.         -   c) cooling contents below 40° C. and off load         -   d) charging a mild neutralizing agent such as             triethanolamine to neutralize the acid catalyst.

In a variation, the acid catalyst is added in an amount that ensures that the pH of 5% by weight of the final product in aqueous solution will be greater than 7.0. In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols comprises reacting cyano-containing nitrification inhibitors with aldehydes at a molar ratio of cyano-containing nitrification inhibitors' aldehyde reactive units to aldehyde units of 1:1. In an embodiment, using NAPAOL as the reaction medium results in a composition of wherein at least 70% or alternatively at least 90% of the total nitrification inhibitor content is a polymeric/oligomeric compound. In a variation, the reaction product can be dispersed within 20-80% NAPAOL.

In an embodiment, reaction product of cyano-containing nitrification inhibitors with aldehydes comprise a molar ratio of cyano-containing nitrification inhibitors' aldehyde reactive units to aldehyde units of 1:1 to 2:1. In an embodiment using NAPAOL as the reaction medium results in a composition wherein at least 50% or alternatively at least 70% of the total nitrification inhibitor content is a polymeric compound. In a variation, the reaction product can be dispersed within 20-80% NAPAOL.

In an embodiment, reaction product of cyano-containing nitrification inhibitors with aldehydes comprise a molar ratio of cyano-containing nitrification inhibitors' aldehyde reactive units to aldehyde units of 2:1 to 4:1. In an embodiment using NAPAOL as the reaction medium results in a composition of wherein at least 30% or alternatively at least 51% of the total nitrification inhibitors content as polymeric/oligomeric compounds. In a variation, the reaction product can be dispersed within 20-80% NAPAOL.

In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises utilizing the NAPAOL dimethyl sulfoxide (DMSO) as the reaction medium for the reaction of paraformaldehyde with dicyandiamide (DCD) In a variation, a method of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises reacting a molar ratio of DCD to formaldehyde of 1:1 within (DMSO) resulting in a composition wherein at least 70% or alternatively at least 90% of the total nitrification inhibitor content is a polymeric compound. In a variation, the reaction product can be dispersed within 20-80% DMSO. In another variation, a method of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises reacting a molar ratio of DCD to formaldehyde of 1:1 to 2:1 within DMSO resulting in a composition of wherein at least 50% or alternatively at least 70% of the total nitrification inhibitor content is a polymeric compound. In a variation, the reaction product can be dispersed within 20-80% DMSO.

In another variation, a method of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises reacting a molar ratio of DCD to formaldehyde of 2:1 to 4:1 within DMSO resulting in a composition of wherein at least 30% or alternatively at least 50% of the total nitrification inhibitor content is a polymeric compound. In a variation, the reaction product can be dispersed within 20-80% DMSO.

In a variation, the reaction product of DCD reacted with paraformaldehyde comprises a molar ratio of DCD to formaldehyde unit of 4:1 wherein the DMSO is the reaction medium results in a composition of approximately 51.9% of the total nitrification inhibitor content as an oligomeric compound and approximately 48.1% free DCD.

In an embodiment, a method of making fertilizer additives or a liquid composition of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols comprise DCD reacted with paraformaldehyde at a molar ratio of DCD to formaldehyde unit of up to 4:1 wherein the NAPAOL, dimethyl sulfoxide (DMSO), is the reaction medium resulting in a composition of approximately 51.9% of the total nitrification inhibitor content as an oligomeric compound and approximately 48.1% free DCD wherein the total concentration of polymer bound and free DCD is 10-60% and the DMSO is 40 to 90% of said liquid fertilizer additives.

In a variation, the DCD reacted with paraformaldehyde at a molar ratio of DCD to formaldehyde unit of up to a 4:1 wherein DMSO, is the reaction medium possesses better water solubility versus a DCD/paraformaldehyde reaction product based on a 2:1 molar wherein the compositional ratio is adjusted to 51.9/48.1 of polymer to free DCD at elevated temperatures of 40-90° C. and equivalent compositional amounts of DMSO.

In an embodiment, a method of making fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols comprise DCD reacted with paraformaldehyde at a molar ratio of DCD to formaldehyde unit of 1:1 to 2:1 wherein the NAPAOL, dimethyl sulfoxide (DMSO), is the reaction medium resulting in a composition of at least 70% of the total nitrification inhibitor content as a polymeric compound wherein the total concentration of polymer bound and free DCD is 10-80%. In a variation, free DCD can be added to the formulation wherein the composition of free DCD is adjusted to 1-60% of the total of free and polymer bound. When free DCD is present, it increases the initial performance of the product as a nitrification inhibitor.

In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise the addition, during the aldehyde reaction, of polyamines comprising one or more members selected from the group consisting of ethylenediamine, diethylenetriamine, triethylenetetramine tetraethylenepentamine and aminoethylethanolamine whereas the polyamines comprise 0.01-5% of the polymer composition weight in order to modify the coatings' properties such as hydrophobicity, coverage, flexibility of the formed film. In a variation, ammonia is added during the formaldehyde reaction. By polymer composition weight, it is meant the nitrification inhibitor composition weight.

In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise the addition, during the aldehyde reaction, of polyols comprising one or more members selected from the group consisting of and/or compounds such as but not limited to one or more polyols selected from the group consisting of 1)trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol and sorbitan, glucose, fructose, galactose, and glycerin, 2) poly(C₁₋₁₀ alkylene) glycols, 3) one or more alkylene glycols from the group consisting of ethylene, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, 4) isopropylidene glycerol 5) one or more alkylene glycol alkyl ethers from the group consisting of tripropylene glycol methyl ether, tripropylene glycol butyl ether, dipropylene glycol butyl ether and tripropylene glycol butyl ether whereas the polyols comprise 0.1-5% of the polymer weight in order to modify the coatings' properties such as hydrophobicity, coverage, flexibility of the formed film.

In an embodiment, the present invention relates to a method of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, wherein the secondary amines may comprise one or more members selected form the group consisting of diethanolamine, diethylamine, cyclohexylamine, methylethanolamine, diisopropanolamine, methylispropylamine. In an embodiment, the secondary amines may comprise 0.1-5% of the polymer weight to assist in controlling the molecular weight build of the biodegradable polymeric and/or oligomeric nitrification inhibitors through chain termination.

In an embodiment, the present invention relates to a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, wherein the additives may further comprise addition of low molecular weight alcohols (during the formaldehyde reaction) wherein the low molecular weight alcohols comprise one or more members selected from the group consisting of methanol, ethanol, butanol, and hexanol. In an embodiment, the low molecular weight alcohols comprise 0.1-5% of the polymer weight to assist in controlling the molecular weight build of the biodegradable polymeric and/or oligomeric nitrification inhibitors through chain termination.

In an embodiment, the composition of liquid fertilizer additive comprising utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, wherein the composition may further comprise the addition of one or more alkoxy capped monomers selected from the group consisting of 1,3,4,6-tetrakis(methoxymethyl)glycoluril, N,N,N′,N′,N″,N″-hexakis(methoxymethyl)-1,3,5-triazine-2,4,6-triamine, tetra(methoxymethyl) urea and di(methoxymethyl) urea for coating of fertilizer granules to promote further crosslinking of compounds containing aldehyde reactive groups on the surface of the fertilizer granule and with the surface of urea granules and for adding to molten urea to increase crosslinking of compounds containing aldehyde reactive groups and reaction with the urea. In a variation, the composition can further comprise urea-formaldehyde polymers, ammonia-formaldehyde polymers, urea-ammonia-formaldehyde polymer and triazone-formaldehyde structures. In a variation, the present invention relates to a composition or liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, wherein the composition may further comprise one or more of members selected from the group consisting of surfactants, buffers, fragrance/odor masking agents, colorants, flow modifiers, silicas, hydrophobized silicas and/or one or more catalysts selected from the group consisting of methane sulfonic acid, sulfuric acid, para-toluene sulfonic acid, phosphoric acid and methane phosphonic acid.

In another variation, the composition may optionally contain one or more biologically active agents and/or biologics selected from the group consisting of a) urease inhibitors, nitrification inhibitors, pesticides, herbicides fungicides(s), and insecticide(s).

In an embodiment, the post reaction composition of liquid fertilizer additive comprising biodegradable polymeric and/or oligomeric nitrification inhibitors using a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups wherein the reactive groups are selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise one or more non-aqueous organo liquids selected from the group consisting of polar aprotic, aprotic and protic organo solvents wherein these groups are as follows:

-   -   a) one or more aprotic solvents selected from the group         consisting of 1) one or more polyols capped with acetate or         formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 2) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and tripropylene         glycol butyl ether acetate and, 3) isophorone, 4) one or more         diesters selected from the group consisting of         dimethylsuccinate, dimethyl adipate, diethyl glutarate, and         dimethyl glutarate, 5) dimethylacetamide, 6)         dimethylformamide, 7) dimethyl-2-imidazolidinone, 8)         1-Methyl-2-pyrrolidone and 9) limonene,     -   b) one or more protic solvents selected from the group         consisting of: 1) an alcohol from the family of C₁₋₁₀         alkanols, 2) one or more polyols selected from the group         consisting of trimethylol propane, trimethylol ethane,         pentaerythritol, sorbitol, sorbitan, glucose, fructose,         galactose, and glycerin, 3) one or more poly(C₁₋₁₀ alkylene)         glycols represented by the structure:         H(C_(t)H_(u))_(v)OH         -   t is an integer: 1-10         -   u is an integer: 2-20         -   and v is an integer: 1-20,     -   4) one or more alkylene glycols selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, and butylene glycol, 5) isopropylidene         glycerol 6) one or more alkylene glycol alkyl ethers selected         from the group represented by the structure:

-   -   -   wherein R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉         -   wherein R² is: H or the structure

-   -   -   wherein R³ is: H or CH₃         -   wherein R⁴ is H and CH₃             -   and f is an integer between 1 and 15,

    -   7) one or more alkyl lactates selected from the group consisting         of ethyl, propyl and butyl lactate, 8) one or more alkanolamines         selected from the group represented by the structure:

-   -   -   wherein R⁵ is: C₂H₄OR⁸ or C₃H₆OH         -   wherein R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH         -   wherein R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH         -   wherein R⁸ is: (C₂H₄O)_(g)H         -   and g is an integer between 1-10,         -   and 9) glycerol carbonate,

    -   c) and one or more polar aprotic solvents selected from the         group consisting of         -   1) dimethyl sulfoxide         -   2) and dialkyl, diaryl, or alkylaryl sulfoxide(s) having the             formula:             R₉S(O)_(x)R₁₀             -   wherein R₉ and R₁₀ are each independently a C₁₋₆                 alkylene group, an aryl group, or C₁₋₃alkylenearyl group                 or R₉ and R₁₀ together with the sulfur to which they are                 attached form a 4 to 8 membered ring wherein R₉ and R₁₀                 together are a C₁₋₆ alkylene group which optionally                 contains one or more atoms selected from the group                 consisting of O, S, Se, Te, N, and P in the ring and x                 is 1 or 2, and optionally further comprising:         -   3) one or more alkylene carbonates selected from the group             consisting of ethylene carbonate, propylene carbonate and             butylene carbonate 4) 1-Methyl-2-pyrrolidone, 5) one or more             organo phosphorous liquids selected from the group             consisting of hexamethylphosphoramide and one or more             trialkylphosphates selected from the group represented by             the formula.

-   -   -   -   wherein:                 -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃                 -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃                 -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

        -   6) 1,2-dimethyloxyethane, 7) 2-methoxyethyl ether and 8)             cyclohexylpyrrolidone.

In an embodiment, said non-aqueous organo liquid solvents can be added to improve the properties of said liquid fertilizer additives, wherein the properties that can be improved include but are not limited to evenness of the coating, viscosity, solubility in aqueous fertilizer such as UAN, dispersibility in anhydrous ammonia and dispersibility in urea and modified ureas such as urea formaldehyde polymer (UFP), shelf life stability and cold weather flowability

In another variation, said non-aqueous organo liquid solvents can be added to impact the properties of the treated nitrogen source such as but not limited to water resistance, clumping of solid nitrogen sources and homogeneity of the dispersion within liquid/molten nitrogen sources.

In a variation, said liquid fertilizer additives may further comprise one or more of members selected from the group consisting of surfactants, buffers, fragrance/odor masking agents, colorants, flow modifiers, silicas, hydrophobized silicas.

In a variation, said liquid fertilizer additives may further comprise one or more biologically active agents and biologics selected from the group consisting of a) urease inhibitors, nitrification inhibitors, pesticides, herbicides fungicides(s), and insecticide(s).

In an embodiment, the present invention relates to a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors, wherein the method is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In an embodiment, the composition may further comprise one or more non-cyano-nitrification inhibitors selected from the group consisting of:

-   -   a) one or more pyrazoles represented by the structure

-   -   Whereas R₂₈=—H, —CH₃, —CH₂CH₃, —NH₂ or —NHCH₃     -   Whereas R₂₉=—H, —OH, —SH, —CONH₂ or —CONHCH₃     -   Whereas R₃₀=—H, —CH₃, —CH₂CH₃, —NH₂ or —NHCH₃     -   Whereas R₃₁=—H, —CH₃, —CH₂CH₃, —NH₂ or —NHCH₃     -   b) one or more members selected from the group consisting of         2-amino-4-chloro-6-methyl-pyrimidine, 1,3-benzothiazole-2-thiol,         4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide, thiourea,         2,4-diamino-6-trichloromethyl-5-triazine,         4-amino-1,2,4-triazole, 3-mercapto-1,2,4-triazole, 2,3,         dihydro-2,2-dimethyl-7-benzofuranol methyl-carbamate,

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises said non-cyano-nitrification inhibitors reacting with paraformaldehyde at a molar ratio of non-cyano-nitrification inhibitors to formaldehyde compounds of 2:1 to 2.5:1 with NAPAOL as the reaction medium. In a variation, the composition results in a composition that comprises at least 50% or alternatively at least 70% of methylene bis non-cyano-nitrification inhibitor oligomers. In another variation, methylene bis non-cyano-nitrification inhibitor oligomers are believed to show improvements on performance issues such as lowering atmospheric volatility and decreasing migration through the soil due to low molecular weight and/or water solubility.

In a variation, the resulting product may also possess nitrification inhibition properties. In a variation, the resulting product may also deliver nitrification inhibition properties due to the biodegradation of the polymer.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols comprise dimethyl pyrazole (DMP) reacting with paraformaldehyde at a molar ratio of DMP to formaldehyde unit of 2:1. In a variation, the NAPAOL comprises one or more members selected from the group consisting of sulfolane and dimethyl sulfoxide as the reaction medium. In another variation, the composition comprises at least 70% of a methylene bis DMP oligomer. In another variation, the resulting liquid fertilizer additive possesses lower atmospheric volatility relative to unreacted DMP. In a variation, the NAPAOL is sulfolane.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a variation, the method may comprise 1) dissolving the non-cyano-nitrification inhibitor in NAPAOL at temperatures in the range of 30-110° C. and cooling to 40-60° C. and ensuring that pH is in the range of 8-10, 2) slowly adding the aldehyde and allowing the exotherm to be controlled either through charge rate or removing the heat of reaction through a cooling median, 3) slowly heating the composition to 70-90° C. and waiting for a period of time, (e.g., 1-10 hours) 4) cooling the composition to 40-70° C. and slowly charging enough of acid catalyst such as but not limited to one or more members selected from the group consisting of methane sulfonic acid, sulfuric acid, para-toluene sulfonic acid phosphoric acid and methane phosphonic acid to drop the pH to 5-8 and let mix for an extended period of time to control the exotherm, 5) slowly heating the composition to 90-115° C.

In a variation, after holding the reaction product enumerated above for a period of time, one can elect to place the batch under a vacuum of 0.1-100 mm to assist in removing water by-products, driving the reaction to more completion and removing any unreacted aldehyde until residual aldehyde content is <700 ppm and then cooling the batch. In a variation, one can remove oxygen from the reactor before the addition of the formaldehyde. In another variation, one can apply a vacuum to the vessel after the addition of the acid catalyst to assist in driving the reaction to completion in a shorter period of time. In another variation, one can alternate between a hard sparge and vacuum to remove excess aldehyde.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols wherein the NAPAOL comprises one or more members selected from the group consisting of:

-   -   a) dimethyl sulfoxide,     -   b) and dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together         with the sulfur to which they are attached form a 4 to 8         membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene         group which optionally contains one or more atoms selected from         the group consisting of O, S, Se, Te, N, and P in the ring and x         is 1 or 2,     -   c) and one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate d) 1-Methyl-2-pyrrolidone, e) one or more         organo phosphorous liquids selected from the group consisting of         hexamethylphosphoramide and one or more trialkylphosphates         selected from the group represented by the formula:

-   -   -   wherein:             -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   f) 1,2-dimethyloxyethane, g) 2-methoxyethyl ether and h)         cyclohexylpyrrolidone,         wherein said nitrification inhibitors that contain one or more         aldehyde reactive groups are selected from the group consisting         of:

    -   a) one or more cyano-containing nitrification inhibitors         selected from the group represented by the structures:

-   -   b) one or more non-cyano-containing nitrification inhibitors         selected from the group consisting of:         -   1) one or more pyrazoles represented by the structure

-   -   -   -   wherein R₂₈=—H, —CH₃, —CH₂CH₃, —NH₂ or —NHCH₃             -   wherein R₂₉=—H, —OH, —SH, —CONH₂ or —CONHCH₃             -   wherein R₃₀=—H, —CH₃, —CH₂CH₃, —NH₂ or —NHCH₃             -   wherein R₃₁=—H, —CH₃, —CH₂CH₃, —NH₂ or —NHCH₃             -   2) one or more members selected from the group                 consisting of 2-amino-4-chloro-6-methyl-pyrimidine,                 1,3-benzothiazole-2-thiol,                 4-amino-N-1,3-thiazol-2-ylbenzenesulfonamide, thiourea,                 2,4-diamino-6-trichloromethyl-5-triazine,                 4-amino-1,2,4-triazole, 3-mercapto-1,2,4-triazole, 2,3,                 dihydro-2,2-dimethyl-7-benzofuranol methyl-carbamate,                 wherein the nitrification inhibitors are reacted with                 said aldehydes utilizing the NAPAOL as the reaction                 medium wherein the one or more aldehydes are selected                 from the group consisting of:

    -   methanal, ethanal, propanal, butanal, pentanal, hexanal,         methylethanal, methylpropanal, methylbutanal,         phenylacetaldehyde, benzaldehyde, 2-propenal, 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid, 6-oxohexanoic acid, 2-oxopropanal,         cyclohexanal, furfural, methyl esters of 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid and 6-oxohexanoic acid, ethandial,         1,3-propanedial, butanedial, pentanedial, phthalaldehyde and         methanethial.

In a variation, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is part of a method comprised of utilizing NAPAOL as the reaction medium for the reaction of aldehyde(s) with nitrification inhibitors may further comprise acid catalyst such as but not limited to one or more members selected from the group consisting of methane sulfonic acid, sulfuric acid, para-toluene sulfonic acid, phosphoric acid and methane phosphonic acid.

In another variation, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing said NAPAOL as the reaction medium for the reaction of said aldehyde(s) with said nitrification may further comprise an agent to neutralize the acid catalyst after the reaction is completed such as but not limited to one or more members selected from the group consisting of NaOH, NaOCH₃, Na₂CO₃, KOH, K₂CO₃, NH₃ and one or more alkanolamines selected from the group represented by the structure:

-   -   wherein R⁵ is: C₂H₄OR⁸ or C₃H₆OH     -   wherein R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH     -   wherein R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH     -   wherein R⁸ is: (C₂H₄O)_(g)H     -   and g is an integer between 1-10.

In another variation, the post reaction composition of liquid fertilizer additive comprising said biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a variation, the post reaction composition may further comprise polar aprotic, aprotic and protic organo solvent wherein the composition of the non-aqueous liquid organo solvents may further comprise:

-   -   a) one or more aprotic solvents selected from the group         consisting of 1) one or more polyols capped with acetate or         formate wherein the polyol portion selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, butylene glycol, trimethylol propane,         trimethylol ethane, pentaerythritol, sorbitol and sorbitan,         glucose, fructose, galactose and glycerin, 2) one or more         alkylene glycol alkyl ethers acetates selected from the group         consisting of dipropylene glycol methyl ether acetate,         tripropylene glycol methyl ether acetate, and tripropylene         glycol butyl ether acetate and, 3) isophorone, 4) one or more         diesters selected from the group consisting of         dimethylsuccinate, dimethyl adipate, diethyl glutarate, and         dimethyl glutarate, 5) dimethylacetamide, 6)         dimethylformamide, 7) dimethyl-2-imidazolidinone, 8)         1-Methyl-2-pyrrolidone and 9) limonene,     -   b) one or more protic solvents selected from the group         consisting of: 1) an alcohol from the family of C₁₋₁₀         alkanols, 2) one or more polyols selected from the group         consisting of trimethylol propane, trimethylol ethane,         pentaerythritol, sorbitol, sorbitan, glucose, fructose,         galactose, and glycerin, 3) one or more poly(C₁₋₁₀ alkylene)         glycols represented by the structure:         H(C_(t)H_(u))_(v)OH         -   t is an integer: 1-10         -   u is an integer: 2-20         -   and         -   v is an integer: 1-20,     -   4) one or more alkylene glycols selected from the group         consisting of ethylene glycol, 1,3 propylene glycol, 1,2         propylene glycol, and butylene glycol, 5) isopropylidene         glycerol 6) one or more alkylene glycol alkyl ethers selected         from the group represented by the structure:

-   -   -   wherein R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉         -   wherein R² is: H or the structure

-   -   -   wherein R³ is: H or CH₃         -   wherein R⁴ is H and CH₃             -   and f is an integer between 1 and 15

    -   7) one or more alkyl lactates selected from the group consisting         of ethyl, propyl and butyl lactate, 8) one or more alkanolamines         selected from the group represented by the structure:

-   -   -   where R⁵ is: C₂H₄OR⁸ or C₃H₆OH         -   where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH         -   where R⁸ is: (C₂H₄O)_(g)H         -   and g is an integer between 1-10         -   and 9) glycerol carbonate,

    -   c) and one or more polar aprotic solvents selected from the         group consisting of         -   1) dimethyl sulfoxide         -   2) and dialkyl, diaryl, or alkylaryl sulfoxide(s) having the             formula:             R₉S(O)_(x)R₁₀             -   wherein R₉ and R₁₀ are each independently a C₁₋₆                 alkylene group, an aryl group, or C₁₋₃alkylenearyl group                 or R₉ and R₁₀ together with the sulfur to which they are                 attached form a 4 to 8 membered ring wherein R₉ and R₁₀                 together are a C₁₋₆ alkylene group which optionally                 contains one or more atoms selected from the group                 consisting of O, S, Se, Te, N, and P in the ring and x                 is 1 or 2, and optionally further comprising         -   3) one or more alkylene carbonates selected from the group             consisting of ethylene carbonate, propylene carbonate and             butylene carbonate 4) 1-Methyl-2-pyrrolidone, 5) one or more             organo phosphorous liquids selected from the group             consisting of hexamethylphosphoramide and one or more             trialkylphosphates selected from the group represented by             the formula.

-   -   -   -   wherein:                 -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃                 -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃                 -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

        -   6) 1,2-dimethyloxyethane, 7) 2-methoxyethyl ether and 8)             cyclohexylpyrrolidone

In an embodiment, said non-aqueous organo liquid solvents can be added to improve the properties of said liquid fertilizer additives such as but not limited to hydrophobicity, viscosity and cold weather flowability and/or the properties of the treated nitrogen source such as but not limited to water resistance, clumping of solid nitrogen sources and solubility in liquid/molten nitrogen sources.

In another variation, the composition may further comprise one or more members selected from the group consisting of:

-   -   a food coloring or dye that may be used to improve the visual         evidence of complete coverage and serve as a visual marker,     -   scents or masking agents to improve the odor of the         formulations,     -   nonionic, anionic, cationic, zwitterionic, and/or amphoteric         surfactants to improve formula application performance of         fertilizer granules;     -   buffering agents     -   flow modifiers, silicas and hydrophobized silicas and     -   catalyst(s) to improve reaction completion.

In another variation, the composition may further comprise one or more members selected from the group consisting of: a) one or more biologically active agents and b) biologics wherein the biologically active agents and biologics may possess one or more properties selected from the group consisting of a) urease inhibitors, nitrification inhibitors, pesticides, herbicides fungicides(s) and insecticide(s)

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano- and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise one or more members selected from the group consisting of: a) one of more biologically active agents and b) one or more biologics wherein the biologically active agents and biologics may possess one or more properties selected from the group consisting of urease inhibitors, nitrification inhibitor(s), pesticide(s), herbicide(s), fungicides(s), and insecticide(s). In a variation, the use of a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors will result in lower dissolution of these biologically active agents that are encapsulated within the hydrophobic film thereby improving performance by increasing the length of time these biologically active agents and biologics are available.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise one or more urease inhibitors selected from the group consisting of aliphatic phosphoric triamide, phosphoramides and N-alkyl thiophosphoric triamides, (aminomethyl)phosphinic acids and their salts and aminomethyl (alkylaminomethyl)phosphinic acids and their salts. In a variation the urease inhibitor is N-(n-butyl) thiophosphoric triamide.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise one or more nitrification inhibitors selected from the group consisting of 2-chloro-6-trichloromethyl)pyridine, 4-amino-1,2,4-6-triazole-HCl, 2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium thiosulfate, dimethylpyrazole organic and inorganic salts and 2-amino-4-chloro-6-methylpyrimidine In a variation the nitrification inhibitor comprises dicyandiamide.

In an embodiment a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise one or more nitrification inhibitors selected from the group consisting of 2-chloro-6-trichloromethyl)pyridine, 4-amino-1,2,4-6-triazole-HCl, 2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium thiosulfate, dimethylpyrazole organic and inorganic salts and 2-amino-4-chloro-6-methylpyrimidine and one or more urease inhibitors selected from the group consisting of aliphatic phosphoric triamide, phosphoramides and N-alkyl thiophosphoric triamides, (aminomethyl)phosphinic acids and their salts and aminomethyl (alkylaminomethyl) phosphinic acids and their salts.

In an embodiment a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may further comprise one or more biologics selected from the group consisting of

-   -   a) one or more Bacillus biologics selected from the group         consisting of         -   1) Bacillus mucilaginosas         -   2) Bacillus subtilus         -   3) Lactobacillus acidophilus         -   4) Bacillus amylofliquifaciens         -   5) Bacillus itcheniformis         -   6) Bacillus megaterium         -   7) Bacillus pumilus         -   8) Bacillus megaterium         -   9) Bacillus pumilus         -   10) Bacillus circulans         -   11) Bacillus globisporus         -   12) Bacillus firmus         -   13)Bacillus thuringiensis galleriae         -   14) Bacillus thuringiensis kurstaki         -   15) Bacillus cereus         -   16) Bacillus globisporus         -   17) Bacillus amyloliquefaciens         -   18) Bacillus thuringiensis galleriae         -   19) Bacillus thuringiensis kurstaki         -   20) Bacillus mycoide isolate         -   21)Bacillus aryabhattai         -   22) B. flexus         -   23) B. nealsonii         -   24) Bacillus sphaericus         -   25) B. vallismortis     -   b) Rhizobium     -   c) Bradyrhiwbium species     -   d) Bradyrhiwbium japonicum     -   e) Rhizobium meliloti     -   f) One or more Azospirillum biologics selected from the group         consisting of         -   1) Azospirillum lipoferum         -   2) Azospirillum brasilense         -   3) Azospirillum amazonense         -   4) Azospirillum halopreaferens         -   5) Azospirillum irankense     -   g) One or more Azobacter and Gluconacetobacter biologics         selected from the group consisting of         -   1) Azotobacter agilis         -   2) Azotobacter armeniacus         -   3) Azotobacter sp. AR         -   4) Azotobacter beijerinckii         -   5) Azotobacter chroococcum         -   6) Azotobacter sp. DCU26         -   7) Azotobacter sp. FA8         -   8) Azotobacter nigricans         -   9) Azotobacter paspali         -   10) Azotobacter salinestris         -   11)Azotobacter tropicalis         -   12) Azotobacter vinelandii     -   h) Phosphobacteria     -   i) Cyanobacteria     -   j) Herbaspirillum     -   k) Burkholderia,     -   l) Pseudomonas     -   m) Gluconacetobacter     -   n) Enterobacter     -   o) Klebsiella     -   p) Burkholderia     -   q) Laccaria bicolor     -   r) Glomus imraradices timanita     -   s) Actinomyces     -   t) Penicillium     -   u) Mesorhizobiwn cicero     -   v) Reynoutria sachalinensis     -   w) One or more insecticidal or insect repellent microbial         species and strains selected from the group consisting of:         Telenomus podisi, Baculovirus anticarsia, Trichogramma         pretiosum, Trichogramma gallai, Chromobacterium subtsugae,         Trichoderma fertile, Beauveria bassiana, Beauveria bassiana,         Beauveria bassiana, Paecilomyces jknwsoroseu, Trichoderma         harzianum, Verticillium lecanii, lsarfofumosarosea Lecanicillium         muscarium, Streptomyces microflavus, Muscodor albus,     -   x) one or more nematodal microbial species and strains selected         from the group consisting of: Myrothecium verrucaria, Pasteuria         species, Pasteuria metarhizium species, Flavobacteriwn species         and     -   y) one or more antifungal, antimicrobial and/or plant growth         promoting microbial species and strains selected from a group         consisting of: Gliocladium species, Pseudomonas species (e.g.         Pseudomonas fluorescens, Pseudomonas fluorescens. putida and P.         chlororaphis), Pseudomonas fluorescens VP5, Pseudomonas         diazotrophicus, Enterobacter cloacae, Trichodema species,         Trichoderma virens, Trichoderma atroviride strains, Coniothyrium         minitans, Gliocladium species, Gliacladium virens, Gliacladium         roseum, Trichodemw harzianum species.

In an embodiment, these new liquid fertilizer additives can be added to a nitrogen source through methods comprising one or more application techniques selected from the group consisting of:

-   -   a. coating a nitrogen source particle with said liquid         fertilizer additives utilizing spraying, metering or slowly         pouring onto a nitrogen source that is in a temperature range of         −20° C. to 100° C. In a variation the mixing of the materials         may be accomplished in a simple mixing tank mixing materials         prior to use, using a metering system to inject materials         simultaneously, or mixing via a spray injection system. In         another variation, the mixture can be mixed in any common mixing         tank, blenders and tumblers or on a conveyer belt. In another         variation, the metering of all ingredients can be based on a         weight, it may also be on a volumetric basis,     -   b. generating during the process a nitrogen source particle,         granule and/or prill in which the liquid formulation can be         added directly into the molten nitrogen source before formation         of a particle, granule or a prill and/or sprayed into the         prilling tower when molten nitrogen source is released from the         top of prilling tower and the falling liquid nitrogen source is         crystallized by air in the tower,     -   c. dissolving liquid fertilizer additive into aqueous liquid         fertilizers and     -   d. incorporating said liquid fertilizer additives into         non-aqueous liquid nitrogen sources such as pressurized         anhydrous ammonia gas.

In a variation, these compositions can be sprayed directly on the soil and/or on natural fertilizers such as manure or compost.

In an embodiment, the usage rates of these new liquid formulations with a nitrogen source is dependent on the application technique, the weight or volume of the nitrogen source applied per acre of soil to be treated, the nitrification inhibitor type, the concentration of polymer bound and free nitrification inhibitors present in the liquid formulation's composition. In a variation, if the application technique is the addition of said liquid fertilizer additives to a liquid/molten nitrogen source, the usage rate will be dependent on the solubility and impact of the desired granule/prill properties.

In a variation, higher levels of total nitrification inhibitors, which are defined as polymer bound and free, can be applied to the soil directly or as a liquid fertilizer additive to natural and manmade nitrogen sources. Moreover, due to the slow release of nitrification inhibitors through the biodegradation of the polymer backbone and the maintenance of an effective level of free nitrification inhibitors, the nitrogen source is made more effective in providing nutrients for plant growth over an extended period of time. In a variation, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may have low percentages of 20-30% of a NAPAOL resulting in lower negative impact of a nitrogen source particles' physical properties such as but not limited to a low hardness index. In a variation, a low hardness index of a particle negatively impacts storage, packaging, blending and distribution. In another variation, low percent composition of NAPAOL in a liquid fertilizer additive may be achieved by running the first reaction process at lower temperatures of 60-80° C. for a longer period of time (e.g. 4-12 hours).

In another variation, low percent composition of NAPAOL in a liquid fertilizer additive may be achieved by running the second reaction process at a lower vacuum (e.g. 0.01-1 mm), increasing the temperature after the second reaction has been completed and any acid catalyst has been neutralized (e.g. 90-120° C.) stripping out NAPAOL to desired levels.

In another variation, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols may be added to molten nitrogen sources at elevated temperatures (e.g. 80-140° C.) to lower said liquid fertilizer additive's viscosity and aide in ensuring a homogeneous distribution within the molten nitrogen source.

In an embodiment, the composition of a fertilizer comprises liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors that are comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols and one or more nitrogen sources selected from a group consisting of urea, urea formaldehyde polymer, treated urea. In an embodiment, the treated urea is defined as a composition comprising a urea and biologically active agents and/or biologics added either through a coating application or added to the urea during the urea production process either in the melt portion or deposited to the urea during the formation of the urea granule when the urea is still hot. In a variation, a liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors comprise 0.05-10% of the fertilizer composition. In another variation, the NAPAOL comprises 0.01-9.5% of the fertilizer composition.

In an embodiment, one can coat a granule of treated nitrogen source with a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors that is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. A treated nitrogen source is defined as a composition comprising a nitrogen source and biologically active agents and/or biologics added either through a coating application or added to the nitrogen source during the nitrogen source's production process either in the melt portion or applied to the nitrogen source during the formation of the nitrogen source's granule.

In a variation, the nitrogen sources and/or the treated nitrogen sources can be mixed with other fertilizer components and then the liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols can be applied. This will impart slower dissolution of these fertilizer components and nitrogen and/or treated nitrogen sources into water because they have been encapsulated within the hydrophobic film. In an embodiment said liquid fertilizer additives will provide free and polymer bound nitrification inhibition, thereby improving performance in providing nutrients for plant growth over an extended period of time.

In one embodiment, a fertilizer comprises a) a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors that is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of 1) primary and secondary amines, 2) amides, 3) thiols, 4) hydroxyls and 5) phenols and urea. In a variation, said liquid fertilizer additives deliver a more hydrophobic coating of free and polymer bound nitrification inhibitors making the urea more effective in providing nutrients for plant growth over an extended period of time.

In an embodiment, the composition of a fertilizer comprises urea and a liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors that is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In another embodiment, the composition of a fertilizer may further comprise one or more members selected from the group consisting of: a) one of more biologically active agents and b) one or more biologics wherein the biologically active agents and biologics may possess one or more properties selected from the group consisting of urease inhibitors, nitrification inhibitor(s), pesticide(s), herbicide(s), fungicides(s), and insecticide(s). In a variation, when the fertilizer is applied to cropland and turf, the new liquid fertilizer additive composition makes the urea more effective in providing nutrients for plant growth over an extended period of time.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols comprises DCD. In a variation, the NAPAOL comprises dimethyl sulfoxide.

In an embodiment, the composition of said liquid fertilizer additives comprises 5-80% the reaction product of aldehyde(s) reacted with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols and 95-20% of a NAPAOL. In a variation, the composition may further comprise 0.05 to 50% of biologically active agents and/or biologics.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a variation, said liquid fertilizer additive composition may further comprise one or more organo polyorganic acids and/or their salts. In a variation, the composition of the polyacid one or more members selected from the group consisting of a monomer homopolymer, a copolymer and/or a terpolymer or one or more members selected from a group consisting of:

-   -   -   aspartic acid         -   glutamic acid         -   maleic anhydride         -   itaconic anhydride         -   citraconic anhydride         -   citric acid; or         -   acrylic acid;             wherein the organo polyorganic acids are present in an             amount that is about 5-50% of the total composition. In a             variation, the cation of the salts of the polyacids comprise             one or more metals selected from the group consisting of Na,             K, Mg, Ca, Fe, Zn, Mn, Cu, Co, Mo, or Ni and one or more             organoamine selected from the group consisting of mono C₁₋₆             amine, di C₁₋₆ amine, tri C₁₋₆ amine, mono ethanol amine,             diethanol amine, triethanol amine, monoisopropyl amine,             diisopropyl amine, triisopropyl amine, diethyl amine,             diethylene triamine, triethyl tetraamine, tetraethyl             pentamine.

In another variation, the composition comprised of said liquid fertilizer additives and said polyacids and/or their salts can be applied to natural and manmade nitrogen sources utilizing one or more application techniques selected from the group consisting of:

-   -   a. coating a nitrogen source particle with said liquid         fertilizer additives utilizing spraying, metering or slowly         pouring onto a nitrogen source that is in a temperature range of         −20° C. to 100° C. In a variation the mixing of the materials         may be accomplished in a simple mixing tank mixing materials         prior to use, using a metering system to inject materials         simultaneously, or mixing via a spray injection system. In         another variation, the mixture can be mixed in any common mixing         tank, blenders and tumblers or on a conveyer belt. In another         variation, the metering of all ingredients can be based on a         weight, it may also be based on a volumetric basis,     -   b. incorporating during the process a nitrogen source particle,         granule and/or prill in which the liquid formulation can be         added directly into the molten nitrogen source before formation         of a particle, granule or a prill and/or sprayed into the         prilling tower when molten nitrogen source is released from the         top of prilling tower and the falling liquid nitrogen source is         crystallized by air in the tower,     -   c. dissolving liquid fertilizer additive into aqueous liquid         fertilizers and     -   d. incorporating said liquid fertilizer additives into         non-aqueous liquid nitrogen sources such as pressurized         anhydrous ammonia gas.

In a variation, said liquid formulations can be sprayed directly onto the soil and onto natural fertilizers such as manure.

In another variation, application of the composition comprised of said liquid fertilizer additives and said polyacids and/or their salts will improve the effectiveness of the treated fertilizer due to the slow release of nitrification inhibitors through the biodegradation of the polymer backbone resulting in the maintenance of an effective level of free nitrification inhibitors. In another variation, the presence of the organo polyacids and/or their salts will assist in freeing soil bound phosphates and micronutrients, provide a micronutrient transport and moisture protection in the root zone when injected subsurface in applications such as anhydrous ammonia. In another variation, the organo polyacids in an acid/anhydride/imide configuration can provide nitrogen conservation to the nitrogen source making the fertilizer more effective in providing nutrients for plant growth over an extended period of time.

In an embodiment, the capability of the NAPAOL to also serve as a non-aqueous organo solvent delivery system (abbreviated as NOSDS) allows the application of the liquid composition to nitrogen sources that utilize moisture sensitive application methods. It has been learned that liquid biodegradable polymeric and/or oligomeric nitrification inhibitors comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols assist to conserve the cyano-group. In a variation, the liquid biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols can possess higher levels of polymer bound and free nitrification inhibitors versus products utilizing a NAPAOL to make solutions of free nitrification inhibitors. In a variation, it has been learned that utilizing a NAPAOL as the reaction medium results in higher compositional weight percent of said liquid biodegradable polymeric and/or oligomeric nitrification inhibitors versus those produced in an aqueous medium nitrification inhibitors.

In an embodiment, the compositions and methods of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors are comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols, wherein said liquid fertilizer additive is applied to the soil directly either before or after the application of a nitrogen source or in a composition with a nitrogen source inhibits the loss of the nitrogen source's nitrogen caused by the microbial process termed nitrification. In a variation, the method of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors wherein the process parameters are optimized to conserve the cyano group of the nitrification inhibitor preventing it from being converted to diaminomethylene urea comprise a) controlling pH of the reaction, b) utilization of a NAPAOL as the reaction medium, c) using a two-step reaction strategy wherein the first reaction incorporates an aldehyde with a cyano-containing nitrification inhibitor that have one or more aldehyde reactive groups selected from the group consisting of i) primary amines, ii) secondary amines, iii) amides, iv) thiols, v) hydroxyls and vi) phenol to form methylol groups and the second is the reaction of the methylol group with an aldehyde reactive group of the nitrification inhibitor to form polymeric and/or oligomeric nitrification inhibitors and d) removing water during the second reaction resulting in improved nitrification inhibition properties.

In an embodiment, a liquid fertilizer additive comprised of biodegradable polymeric and/or oligomeric nitrification inhibitors resulting from the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols utilizing a NAPAOL as the reaction medium has improved nitrification inhibition properties when compared to its monomeric form. In an embodiment, there is a maximum polymer weight of biodegradable polymeric and/or oligomeric nitrification inhibitors resulting from the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols utilizing a NAPAOL as the reaction medium wherein the viscosity, water solubility and biodegradability properties of the liquid fertilizer additive negatively impact nitrification inhibition.

In an embodiment, a liquid fertilizer additive comprised of a) biodegradable polymeric and/or oligomeric nitrification inhibitors resulting from the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of i) primary amines, ii) secondary amines, iii) amides, iv) thiols, v) hydroxyls and vi) phenols b) utilizing a NAPAOL as the reaction medium and c) one or more nitrification inhibitors selected from the group consisting of 2-chloro-6-trichloromethyl)pyridine, 4-amino-1,2,4-6-triazole-HCl, 2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium thiosulfate, dimethylpyrazole and/or its organic and inorganic salts and 2-amino-4-chloro-6-methylpyrimidine has improved nitrification inhibition properties when compared to the monomeric form of the added nitrification inhibitors. In a variation, the composition can further comprise protic and aprotic solvents.

In an embodiment, liquid fertilizer additives comprises:

-   -   1) a NAPAOL,     -   2) aldehydes     -   3) one or more nitrification inhibitors selected from the group         consisting of 2-chloro-6-trichloromethyl)pyridine,         4-amino-1,2,4-6-triazole-HCl,         2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide         (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium         thiosulfate, dimethylpyrazole and/or its organic and inorganic         salts and 2-amino-4-chloro-6-methylpyrimidine,     -   4) one or more dicyandiamide-formaldehyde adducts selected from         the group consisting of the following structures:         -   i)

-   -   -   ii)

wherein the NAPAOL comprises one or more members selected from the group consisting of:

-   -   a) dimethyl sulfoxide,     -   b) and dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together         with the sulfur to which they are attached form a 4 to 8         membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene         group which optionally contains one or more atoms selected from         the group consisting of O, S, Se, Te, N, and P in the ring and x         is 1 or 2,     -   c) and one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate d) 1-Methyl-2-pyrrolidone, e) one or more         organo phosphorous liquids selected from the group consisting of         hexamethylphosphoramide and one or more trialkylphosphates         selected from the group represented by the formula:

-   -   -   wherein:             -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   f) 1,2-dimethyloxyethane, g) 2-methoxyethyl ether and h)         cyclohexylpyrrolidone,         wherein the one or more aldehydes are selected from the group         consisting of:

    -   methanal, ethanal, propanal, butanal, pentanal, hexanal,         methylethanal, methylpropanal, methylbutanal,         phenylacetaldehyde, benzaldehyde, 2-propenal, 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid, 6-oxohexanoic acid, 2-oxopropanal,         cyclohexanal, furfural, methyl esters of 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid and 6-oxohexanoic acid, ethandial,         1,3-propanedial, butanedial, pentanedial, phthalaldehyde and         methanethial,         wherein the said liquid fertilizer composition can added to         molten urea and/or ammonia resulting in an in situ modification         of urea and/or ammonia within the urea manufacturing process,         and wherein the NAPAOL would have urea solubilizing properties         ensuring a more homogeneous distribution of nitrification         inhibitors within the urea.

In a variation R₃₂-R₄₁ further comprise one or more members independently selected from the group consisting of: CH₂—Z,

-   -   wherein Z=DCD or a DCD-formaldehyde adduct.

In a variation, the NAPAOL is dimethyl sulfoxide.

In an embodiment, a method of making liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols is designed such that the aldehyde is reacted to its methylol function versus continued reaction with formaldehyde reactive groups crosslinking to the methylene function wherein the molar ratio is set to ensure that the aldehyde to aldehyde reactive groups ratio available in said cyano-containing nitrification inhibitors. In a variation, the methylol function can be capped to an alkoxy group comprising of —CH3 to —C4H9 alkyl radical —NI—CH₂—OH vs NI—CH2-NI

In an embodiment, the following drawings of dicyandiamide reacted with formaldehyde would represent desired structure formed versus crosslinking to the methylene function:

In an embodiment, the molar ratio of said aldehyde to said cyano-containing nitrification inhibitors' aldehyde reactive groups comprise 1:1 to 4:1. In a variation, the molar ratio of said aldehyde to said cyano-containing nitrification inhibitors is set with an excess of aldehyde groups to ensure reactive methylol groups present after the reaction is terminated. In a variation, the ratio of aldehyde groups to aldehyde reactive groups further comprise >4:1

In an embodiment, the reaction parameters and molar ratios can be set such that the formation of methylene bridges is limited resulting in a liquid fertilizer additive—AMC (aldehyde-methylol containing) comprising unreacted aldehyde, nitrification inhibitors and nitrification inhibitors-aldehyde reaction product containing methylol functions wherein the method to make may comprise 1) dissolving the nitrification inhibitor in NAPAOL at temperatures in the range of 20-110° C. and cooling to 20-60° C. and ensuring that pH is in the range of 8-10, 2) slowly adding the aldehyde and allowing the exotherm to be controlled either through charge rate or removing the heat of reaction through a cooling medium while holding the temperature at 40-60° C., 3) Heat vessel contents at 60-100° C. for 2 to 18 hours and then cool to <40° C. In a variation, the nitrification inhibitor is dissolved in a NAPAOL at 20-80° C. and the aldehyde is subsequently dispersed into the dissolved and/or dispersed nitrification inhibitor wherein the composition is a liquid fertilizer additive-A (aldehyde).

In a variation, the reaction parameters and molar ratios can be set such that the formation of methylene bridges is limited resulting in a liquid fertilizer additive-AMC comprising unreacted aldehyde, nitrification inhibitors and/or nitrification inhibitors-aldehyde reaction product containing methylol functions wherein the method to make may comprise 1) charging the nitrification inhibitor and aldehyde in a NAPAOL at temperatures in the range of 20-40° C. and then removing oxygen from the vessel's headspace, 2) slowly heat vessel contents to 60-100° C., 3) Hold at 60-100° C. for 2 to 18 hours and then cool to <40° C.

In an embodiment, a liquid fertilizer additive—AMC and or a liquid fertilizer-A can be added to molten urea, molten urea/ammonia and ammonia to disperse into the nitrogen source and react with the urea, urea and ammonia and ammonia incorporating nitrification inhibitors into the backbone of a urea-formaldehyde and/or a urea-ammonia-formaldehyde polymer with even distribution of the nitrification inhibitor throughout the resulting polymer.

The reaction parameters and molar ratios can be set such that the formation of methylene bridges is favored, the said nitrification inhibitors-aldehyde adduct can be further reacted with an aldehyde resulting in a liquid fertilizer additive comprising unreacted aldehyde, nitrification inhibitors, nitrification inhibitors-aldehyde reaction product and nitrification inhibitors-aldehyde reaction product containing methylol functions wherein the method to make comprises one or more of the following steps selected from the group consisting of:

-   -   a) charging said aldehydes, said nitrification inhibitors and         said NAPAOL to reaction vessel and start mixing,     -   b) heating contents of the vessel to 50-90° C. and hold at         temperature for 1-7 hours,     -   c) cooling to 40-60° C., charging an acid catalyst such as but         not limited to one or more members selected from the group         consisting of methane sulfonic acid, sulfuric acid, para-toluene         sulfonic acid phosphoric acid and methane phosphonic acid,         placing reaction vessel under a vacuum of 0.5-50 mm, increasing         temperature to 90-120° C. and hold under vacuum and at         temperature until distillation ceases, cool to 40° C.,     -   d) adjust pH to 8-10 with 10% NaOH or KOH and then 10-200% more         aldehyde calculated on the amount of initial aldehyde charged,     -   e) Heat contents of vessel to 70-80° C. and hold for 1-5 hours,     -   f) Optional to cool batch below 40° C. for storage,

In a variation, the material from step “d” can be added as is to molten urea, molten urea/ammonia and ammonia to disperse into the nitrogen source and react with the urea, urea and ammonia and ammonia incorporating blocks of nitrification inhibitors into the backbone of a urea-formaldehyde and/or a urea-ammonia-formaldehyde polymer. In another variation, the polymeric/oligomeric nitrification inhibitor comprises dicyandiamide wherein when added to a molten nitrogen source can form hydrophobic DCD blocks creating zones of water resistance within the resulting urea particle,

In another variation, the material from step “e” can be added as is to molten urea, molten urea/ammonia and ammonia to disperse into the nitrogen source and react with the urea, urea and ammonia and ammonia incorporating blocks of nitrification inhibitors into the backbone of a urea-formaldehyde and/or a urea-ammonia-formaldehyde polymer. In another variation, the polymeric/oligomeric nitrification inhibitor comprises dicyandiamide segments wherein when added to a molten nitrogen source can form hydrophobic DCD blocks creating zones of water resistance within the resulting urea particle.

In an embodiment, the nitrogen source fertilizer particles formed from the urea and/or urea-ammonia molten liquid containing the in situ polymerization of the urea and urea ammonia with the liquid fertilizer additives that comprise:

-   -   5) a NAPAOL,     -   6) aldehydes     -   7) one or more nitrification inhibitors selected from the group         consisting of 2-chloro-6-trichloromethyl)pyridine,         4-amino-1,2,4-6-triazole-HCl,         2,4-diamino-6-trichloromethyltriazine CL-1580, dicyandiamide         (DCD), thiourea, 1-mercapto-1,2,4-triazole, ammonium         thiosulfate, dimethylpyrazole and/or its organic and inorganic         salts and 2-amino-4-chloro-6-methylpyrimidine,     -   8) one or more dicyandiamide-formaldehyde adducts selected from         the group consisting of the following structures:         -   i)

-   -   -   ii)

wherein the NAPAOL comprises one or more members selected from the group consisting of:

-   -   a) dimethyl sulfoxide,     -   b) and dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together         with the sulfur to which they are attached form a 4 to 8         membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene         group which optionally contains one or more atoms selected from         the group consisting of O, S, Se, Te, N, and P in the ring and x         is 1 or 2,     -   c) and one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate d) 1-Methyl-2-pyrrolidone, e) one or more         organo phosphorous liquids selected from the group consisting of         hexamethylphosphoramide and one or more trialkylphosphates         selected from the group represented by the formula:

-   -   -   wherein:             -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃             -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   f) 1,2-dimethyloxyethane, g) 2-methoxyethyl ether and h)         cyclohexylpyrrolidone,         wherein the one or more aldehydes are selected from the group         consisting of:

    -   methanal, ethanal, propanal, butanal, pentanal, hexanal,         methylethanal, methylpropanal, methylbutanal,         phenylacetaldehyde, benzaldehyde, 2-propenal, 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid, 6-oxohexanoic acid, 2-oxopropanal,         cyclohexanal, furfural, methyl esters of 3-oxopropanoic,         2-methyl-3-oxopropanoic acid, 4-oxobutanoic acid, oxoacetic         acid, 5-oxopentanoic acid and 6-oxohexanoic acid, ethandial,         1,3-propanedial, butanedial, pentanedial, phthalaldehyde and         methanethial,         wherein the said liquid fertilizer composition can added to         molten urea and/or ammonia resulting in an in situ modification         of urea and/or ammonia within the urea manufacturing process,         and wherein the NAPAOL would have urea solubilizing properties         ensuring a more homogeneous distribution of nitrification         inhibitors within the urea.         have one or more properties selected from the group consisting         of

    -   higher crush resistance

    -   lower water solubility due to the formation of zones of water         resistance

    -   nitrification inhibition

    -   extended available of nitrogen in a plant available form

    -   reduced migration of nitrification inhibitor through the soil

In a variation, the resulting polymers formed have through the in situ polymerization method of making have better distribution of DCD within the polymer/oligomer structure ensuring lower levels of free DCD within the fertilizer nitrogen source particles and extending the availability of the nitrogen from the fertilizer in a plant available form. In another variation, because of the slower release of the nitrification inhibitors into the soil due to poorer water solubility and to the time for biodegradation of the nitrification inhibitor-formaldehyde adduct that has been further reacted with urea and/or urea-ammonia, increased levels of application of the said liquid fertilizer additive can be added with improved benefits from additional nitrification inhibition.

In an embodiment, a composition of a fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors is comprised of DCD and one or more members selected from the group consisting of:

-   -   a) Modified DCD represented by the structure

-   -   wherein R₄₃, R₄₄, R₄₅ and R₄₆ are one or more members         independently selected from the group consisting of: H and         —CH₂OH     -   b) a methylene bis dicyandiamide represented by the structure:

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂OH

    -   c) a trimer of a dicyandiamide-formaldehyde reaction product         represented by the structure:

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂OH

    -   d) and a polymer of a dicyandiamide-formaldehyde reaction         product represented by the structure:

-   -   -   wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂OH

    -   e) Formaldehyde

In a variation, it is recognized that generic dicyandiamide structure as described herein also has tautomer shown below:

-   -   and therefore both are included in structural description.

In an embodiment, the compositions and methods of making nitrification inhibitors are comprised of DCD and one or more members selected from the group consisting of:

-   -   f) Modified DCD represented by the structure

-   -   wherein R₄₃, R₄₄, R₄₅ and R₄₆ are one or more members         independently selected from the group consisting of: H and         —CH₂OH     -   g) a methylene bis dicyandiamide represented by the structure:

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂OH

    -   h) a trimer of a dicyandiamide-formaldehyde reaction product         represented by the structure:

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂OH

    -   i) and a polymer of a dicyandiamide-formaldehyde reaction         product represented by the structure:

-   -   -   wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂OH and wherein x=2-20

    -   j) Formaldehyde.

The compositions and methods of the instant invention are comprised of a) utilizing one or more non-aqueous polar, aprotic organo liquid (NAPAOL) selected from the group consisting of:

-   -   a) dimethyl sulfoxide,     -   b) an dialkyl, diaryl, or alkylaryl sulfoxide(s) having the         formula:         R₉S(O)_(x)R₁₀,     -   wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group,         an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together         with the sulfur to which they are attached form a 4 to 8         membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene         group which optionally contains one or more atoms selected from         the group consisting of O, S, Se, Te, N, and P in the ring and x         is 1 or 2,     -   c) one or more alkylene carbonates selected from the group         consisting of ethylene carbonate, propylene carbonate and         butylene carbonate d) 1-Methyl-2-pyrrolidone, e) one or more         organo phosphorous liquids selected from the group consisting of         hexamethylphosphoramide and one or more trialkylphosphates         selected from the group represented by the formula:

-   -   -   wherein:         -   R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃         -   R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃         -   R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃

    -   f) 1,2-dimethyloxyethane, g) 2-methoxyethyl ether and h)         cyclohexylpyrrolidone,         as the reaction medium for the reaction of formaldehyde with         dicyandiamide wherein said nitrification inhibitor composition         is applied to the soil directly either before or after the         application of a nitrogen source or in a composition with a         nitrogen source to inhibit the loss of the nitrogen source's         nitrogen caused by the microbial process termed nitrification.         In a variation, the method of making said nitrification         inhibitor compositions wherein the process parameters are         optimized to conserve the cyano group of the nitrification         inhibitor preventing it from being converted to diaminomethylene         urea comprise a) controlling pH of the reaction, b) utilization         of a NAPAOL as the reaction medium, c) using a two-step reaction         strategy wherein the first reaction incorporates formaldehyde         with dicyandiamide forming a methylol group and the second is         the reaction of the methylol group with an aldehyde reactive         group dicyandiamide to form polymeric and/or oligomeric         nitrification inhibitor composition and d) removing water during         the second reaction resulting in improved nitrification         inhibition properties.

In an embodiment, a fertilizer comprises one or more nitrogen sources selected from the group consisting of a) urea, b) urea formaldehyde reaction products, c) ammonia, d) urea formaldehyde and ammonia reaction products, e) ammonium nitrate, f) ammonium sulfate, e) manure and f) compost liquid, and a nitrification inhibitor composition is comprised of DCD and one or more nitrification inhibitors selected from the group consisting of:

-   -   a) Modified DCD represented by the structure

-   -   wherein R₄₃, R₄₄, R₄₅ and R₄₆ are one or more members         independently selected from the group consisting of: H and         —CH₂OH     -   b) a methylene bis dicyandiamide represented by the structure:

-   -   -   wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more             members independently selected from the group consisting of:             H, and —CH₂OH

    -   c) a trimer of a dicyandiamide-formaldehyde reaction product         represented by the structure:

-   -   -   wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or             more members independently selected from the group             consisting of: H and —CH₂OH

    -   d) and a polymer of a dicyandiamide-formaldehyde reaction         product represented by the structure:

-   -   -   wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or             more members independently selected from the group             consisting of: H and —CH₂OH and x=2-20,

    -   e) Formaldehyde.

In a variation, said nitrification inhibitor composition can be applied to a nitrogen source through a coating or spraying application, added to the urea during the urea production process either in the melt portion or deposited to the urea during the formation of the urea granule when the urea is still hot, blended into liquefied ammonia gas and added to an aqueous fertilizers such as UAN. In a variation, application levels of said nitrification inhibitors comprise 0.05-10% of the nitrogen source composition. In another variation, the NAPAOL comprises 0.01-9.5% of the fertilizer composition.

In an embodiment, when a nitrification inhibitor containing methylol groups is added to a molten urea, the methylol groups can further react with urea, chemically incorporating the nitrification inhibitors composition into the urea granule. In a variation, the urea particle will have better physical properties, more hydrophobic and contain slow release nitrification inhibitors in combination with more traditional inhibitors. In a variation, the nitrification inhibitor compositions can be added to molten urea and/or to the surface of the resulting hot urea particle aiding in slowing down the dissolution of the urea particle.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a variation, said liquid fertilizer additive composition may further comprise one or more organo polycarboxylic acids (OPCA) and/or their salts. In a variation, the composition of the polyacid comprises one or more members selected from the group consisting of a monomer homopolymer, a copolymer and/or a terpolymer of one or more members selected from a group consisting of:

-   -   -   aspartic acid         -   glutamic acid         -   maleic anhydride         -   itaconic anhydride         -   citraconic anhydride         -   citric acid; or         -   acrylic acid;

In another variation, the OPCAs are further comprised of one or more amino polycarboxylic acids and/or their salts selected from the group consisting of: ethylenediaminetetraacetic acid, N-hydroxyethylethlyenediaminetriacetic acid, diethylenetriaminepentaacetic acid, cyclohexanediaminetetraacetic acid, propylenediaminetetraacetic acid, Iminodisuccinic acid, ethylenediamine-N,N′-disuccinic acid, Methylglycinediacetic acid, L-glutamic acid N,N-diacetic acid, nitrilotriacetic acid, N,N-bis(carboxymethyl)glutamic acid, Ethylenediamine-N,N′-bis(2-hydroxyphenylacetic acid, N,N′-Bis(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid, Glycine, N,N′-ethylenebis(N-salicyl) and Iminodisuccinic acid.

wherein the organo polycarboxylic acids are present in an amount that is about 1-50% of the total composition. In a variation, the cation of the salts of the polyacids comprise one or more members selected from the group consisting of Na, K, Mg, Ca, Fe, Zn, Mn, Cu, Co, Mo, or Ni and one or more organoamine selected from the group consisting of mono C₁₋₆ amine, di C₁₋₆ amine, tri C₁₋₆ amine, mono ethanol amine, diethanol amine, triethanol amine, monoisopropyl amine, diisopropyl amine, triisopropyl amine, diethyl amine, diethylene triamine, triethyl tetraamine, tetraethyl pentamine.

In an embodiment, a composition of a) liquid fertilizer additives of biodegradable polymeric and/or oligomeric nitrification inhibitors comprised utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols and b) one or more said organo polycarboxylic acids (OPCA) and/or their salts further comprise one or more nitrogen sources selected from the group consisting of: a) urea, b) urea formaldehyde reaction products, c) ammonia, d) urea formaldehyde and ammonia reaction products, e) ammonium nitrate, f) ammonium sulfate, e) manure and f) compost. In a variation, the liquid fertilizer additives can deliver nitrification inhibition and provide micro-nutrients, properties of freeing soil bound phosphates and micro-nutrients and soil conditioning properties.

In an embodiment, a composition comprising of said biodegradable polymeric and/or oligomeric nitrification inhibitors, OPCAs and anhydrous ammonia can deliver slow release nitrification inhibition, slow migration of nitrification inhibitors and freed/complexed phosphates and nutrients through the soil and provide soil conditioning and improved transport of moisture and nutrients in the root zone through sub-soil injection.

In an embodiment, a composition comprising of said biodegradable polymeric and/or oligomeric nitrification inhibitors, OPCAs and molten urea can deliver the benefits of the OPACs internally to urea solid particles such as prill and granules.

In an embodiment, a composition comprising of said biodegradable polymeric and/or oligomeric nitrification inhibitors, OPCAs in acid, ester or imide form, (aminomethyl)phosphinic acids and their salts, aminomethyl (alkylaminomethyl)phosphinic acids and their salts, dialkylaminomethyl phosphinic acids and their salts and a nitrogen source such as urea or manure can slow the loss of the nitrogen sources' ammonia, slow the conversion of ammonia to nitrates, slow the migration of nutrients through the soil and maintain the residual phosphates and micronutrients in a plant available form.

In an embodiment, a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprises utilizing a NAPAOL as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors and/or non-cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary amines, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols. In a variation, said liquid fertilizer additive composition may further comprise one or more organo polycarboxylic acids (OPCA) and/or their salts selected from the group consisting of a) organo polycarboxylic acid polymers and/or their salts wherein the polymer is a monomer homopolymer, a copolymer and/or a terpolymer comprised of one or more members selected from the group consisting of:

-   -   aspartic acid,     -   glutamic acid,     -   maleic anhydride,     -   itaconic anhydride,     -   citraconic anhydride,     -   citric acid, and     -   acrylic acid         b) one or more amino polycarboxylic acids and/or their salts         selected from the group consisting of:         ethylenediaminetetraacetic acid,         N-hydroxyethylethlyenediaminetriacetic acid,         diethylenetriaminepentaacetic acid,         cyclohexanediaminetetraacetic acid, propylenediaminetetraacetic         acid, Iminodisuccinic acid, ethylenediamine-N,N′-disuccinic         acid, Methylglycinediacetic acid, L-glutamic acid N,N-diacetic         acid, nitrilotriacetic acid, N,N-bis(carboxymethyl)glutamic         acid, Ethylenediamine-N,N′-bis(2-hydroxyphenylacetic acid,         N,N′-Bis(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid,         Glycine, N,N′-ethylenebis(N-salicyl) and Iminodisuccinic acid.         wherein the organo polycarboxylic acids are present in an amount         that is about 1-50% of a total composition and wherein a cation         of salts of the polyacids comprise one or more member selected         from the group consisting of one or more metals and one or more         organoamines wherein the one or more metals are selected from         the group consisting of Na, K, Mg, Ca, Fe, Zn, Mn, Cu, Co, Mo,         and Ni and wherein the one or more organoamines are selected         from the group consisting of mono C₁₋₆ amine, di C₁₋₆ amine, tri         C₁₋₆ amine, mono ethanol amine, diethanol amine, triethanol         amine, monoisopropyl amine, diisopropyl amine, triisopropyl         amine, and diethyl amine.

The following references are incorporated by reference in their entireties for all purposes.

3,264,089 Hansen 3,342,577 Blauin 3,475,154 Kato 5,219,465 Goertz 5,538,531 Hudson 5,599,374 Detrick 5,653,782 Stern 5,803,946 Petcavich 6,338,746 Detrick 6,663,686 Geiger 9,440,890 Gabrielson 20100011825 Ogle 20040016276 Wynnyk CN104803807 Yuan CN 104446875 Li CN 104609983 Chen 4,551,166 Behnke

-   Baligar V C, B. O. (1986). “NPK-fertilizer efficiency—a situation     analysis for the tropics.” Fertilizer Research 10(2): 147-164. -   Bennett E M, C. S. a. C. N. (2001). “Human Impact on Erodable     Phosphorus and Eutrophication: A Global Perspective -   Increasing accumulation of phosphorus in soil threatens rivers,     lakes, and coastal oceans with eutrophication.” BioScience 51:     227-234. -   Christians, N. (2004). ““Fertilization”. Fundamentals of Turfgrass     Management (2nd ed.).” 137-138. -   Dobermann, A. and K. G. Cassman (2005). “Cereal area and nitrogen     use efficiency are drivers of future nitrogen fertilizer     consumption.” Sci China C Life Sci 48 Spec No: 745-758. -   Fan, X., Li, F., Liu, F., and Kumar, D. (2004). “Fertilization with     a new type of coated urea: Evaluation for nitrogen efficiency and     yield in winter wheat.” J. Plant Nutr. 27: 853-865. -   Kross, B. C., et al. (1993). “The nitrate contamination of private     well water in Iowa.” Am J Public Health 83(2): 270-272. -   TLAL (1998). “Soil quality and agricultural sustainability.” 58. -   Linsay, W. (1979). “Chemical Equilibrium in Soils.” -   S, S. (2012). “An Agricultural Pollutant: Chemical Fertilizer.”     International Journal of Environmental Science and Development 3(1):     77. -   Ebisuno, Takimoto, Takahashi, Shiba, (1993) “Preparation and     Structure of a Tetrasubstituted Derivative of N″-Cyanoguanidine,     N,N,N′,N′-Tetrabenzyl-N″-cyanoguanidine.”     -   It should be understood that the present invention is not to be         limited by the above description. Modifications can be made to         the above without departing from the spirit and scope of the         invention. It is contemplated and therefore within the scope of         the present invention that any feature that is described above         can be combined with any other feature that is described above.         Moreover, it should be understood that the present invention         contemplates minor modifications that can be made to the         formulations, compositions, fertilizer additives and methods of         the present invention. When ranges are discussed, any number         that may not be explicitly disclosed but fits within the range         is contemplated as an endpoint for the range. For example, if a         range of 35-60 is given, it should be understood, that any         number between 35 and 60 can be used as the end point for said         range (e.g., 36, 37, 38, etc.). Moreover, if a list of species         within a genus are listed, it is contemplated that any         particular species or any group of species within the genus is         contemplated as being a subgenus that fits within the scope of         the invention. The scope of protection to be afforded is to be         determined by the claims which follow and the breadth of         interpretation which the law allows. 

We claim:
 1. A method of making a fertilizer composition wherein the fertilizer composition comprises a) urea and b) a modified urea, wherein the modified urea is created by a reaction of urea with one or more biodegradable polymeric and/or oligomeric nitrification inhibitors, which has one or more reactive functionalities selected from the group consisting of methylol and dimethylene ether functionalities (BPONI), said reaction generating the modified urea, which is selected from the group consisting of: i)

wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members independently selected from the group consisting of: H and —CH₂—NH—CO—NH₂, ii)

wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more members independently selected from the group consisting of: H, and —CH₂—NH—CO—NH₂ iii)

wherein R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉ and R₆₀ are one or more members independently selected from the group consisting of: H and —CH₂—NH—CO—NH₂ iv)

wherein R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇ and R₆₈ are one or more members independently selected from the group consisting of: H and —CH₂—NH—CO—NH₂ and x=2-20, wherein the method of making the composition comprises reacting molten urea with the BPONI in a temperature range of 80-140° C., and wherein each modified urea i)-iv) has at least one —CH₂—NH—CO—NH₂ functionality.
 2. The method of making the fertilizer composition of claim 1, wherein the fertilizer composition further comprises a) unreacted dicyandiamide and b) a NOSDS (Non-aqueous Organic Solvent Delivery System) wherein the NOSDS comprises a) a NAPAOL (non-aqueous polar, aprotic organo liquid) and one or more solvents selected from the group consisting a) an aprotic NOSDS and b) a protic NOSDS wherein the NAPAOL comprises one or more members selected from the group consisting of: i) dimethyl sulfoxide, ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the formula: R₉S(O)_(x)R₁₀, wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together with the sulfur to which they are attached form a 4 to 8 membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene group which optionally contains one or more atoms selected from the group consisting of O, S, Se, Te, N, and P in the ring and x is 1 or 2, and iii) one or more alkylene carbonates selected from the group consisting of ethylene carbonate, propylene carbonate and butylene carbonate, wherein the aprotic NOSDS comprises one or more members selected from the group consisting of: i) dimethyl sulfoxide, ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the formula: R₉S(O)_(x)R₁₀, wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together with the sulfur to which they are attached form a 4 to 8 membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene group which optionally contains one or more atoms selected from the group consisting of O, S, Se, Te, N, and P in the ring and x is 1 or 2, iii) one or more alkylene carbonates selected from the group consisting of ethylene carbonate, propylene carbonate and butylene carbonate, iv) one or more alkyl pyrrolidones selected from the group consisting of 1-Methyl-2-pyrrolidone and butyl pyrrolidone, v) one or more organo phosphorous liquids selected from the group consisting of hexamethylphosphoramide and one or more trialkylphosphates selected from the group represented by the formula:

wherein: R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃ R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃ R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃ vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether and viii) cyclohexylpyrrolidone, wherein the one or more protic solvents are selected from the group consisting of: i) an alcohol from the family of C₁₋₁₀ alkanols, ii) one or more polyols selected from the group consisting of trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol, sorbitan, glucose, fructose, galactose, and glycerin, iii) poly(C₁₋₁₀ alkylene) glycols, iv) one or more alkylene glycols selected from the group consisting of ethylene glycol, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, v) isopropylidene glycerol vi) one or more alkylene glycol alkyl ethers represented by the structure:

where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉

where R² is: H or where R³ is: H or CH₃ where R⁴ is H and/or CH₃ and f is an integer between 1 and 15, vii) one or more alkyl lactates from the group consisting of ethyl, propyl and butyl lactate, viii) one or more alkanolamines represented by the structure:

where R⁵ is: C₂H₄OR⁸ or C₃H₆OH where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH where R⁸ is: (C₂H₄O)_(g)H and g is an integer between 1-10, and ix) glycerol carbonate.
 3. The method of making the fertilizer composition of claim 1, wherein the fertilizer composition further comprises one or more members selected from the group consisting of: a. a colorant that does not contain water and/or an alcohol; b. scents or masking agents; c. Nonionic, anionic, cationic, zwitterionic, and/or amphoteric surfactants; d. Buffering agents; and e. Catalyst(s).
 4. The method of making the fertilizer composition of claim 1, wherein the fertilizer composition is a solid and the solid fertilizer composition is made by one or more processes selected from the group consisting of a) an urea rotating drum granulation, b) an urea fluidized bed granulation and c) an urea prilling tower process.
 5. The method of making the fertilizer composition of claim 4, wherein the urea rotating drum granulation process comprises one or more steps selected from the group consisting of: a. a step wherein the BPONI is charged and mixed into the molten urea forming the modified urea, b. a step wherein the fertilizer composition is pumped to the spraying nozzles, c. a step wherein the fertilizer composition is sprayed onto a bed of urea particles inside a rotating drum to coat the urea particles with a thin layer of the fertilizer composition, d. a step wherein forced air is passed over the bed of urea particles removing heat and allowing the thin layer of the fertilizer composition to solidify, e. a step wherein the urea rotating drum granulation process is repeated.
 6. The method of making the fertilizer composition of claim 4, wherein the urea fluidized bed granulation process comprises one or more steps selected from the group consisting of: a. a step wherein the BPONI is charged and mixed into the molten urea forming modified urea, b. a step wherein the fertilizer composition is pumped to the spraying nozzles, c. a step wherein the fertilizer composition is sprayed onto a bed of urea particles inside a fluid bed granulator thereby coating the urea particles with a thin layer of the fertilizer composition, d. a step wherein rotating or rolling of the urea particles is accomplished by use of large volumes of air blown up through the bed of urea particles thereby removing heat and allowing the thin layer of the fertilizer composition to solidify, e. a step wherein the process is repeated.
 7. The method of making the fertilizer composition of claim 4, wherein the urea willing process comprises one or more steps selected from the group consisting of: a. a step wherein the BPONI is charged and mixed into the molten urea forming modified urea, b. a step wherein the fertilizer composition is pumped to shower generating heads at the top of a prilling tower, c. a step wherein droplets of the the fertilizer composition form as they pass through the shower generating heads into the prilling tower, d. a step wherein counter current air flows up the prilling tower cooling the droplets below a freezing point and thus, form prills.
 8. The method of making the fertilizer composition of claim 1, wherein the fertilizer composition further comprises one or more unreactive biodegradable polymeric and/or oligomeric nitrification inhibitors (UBPONI) with no reactive functionalities.
 9. The method of making the fertilizer composition of claim 8, wherein the fertilizer composition further comprises a NAPAOL (non-aqueous polar, aprotic organo liquid) as a reaction medium wherein the BPONI containing methylol and/or dimethylene ether functionalities have solubility in the NAPAOL, and wherein a compositional weight ratio of reactive BPONI and unreactive UBPONI to NAPAOL is in a weight range of about 40-80%, and wherein a compositional weight ratio of the reactive BPONI and unreactive UBPONI and NAPAOL to urea is in a weight range of about 15-0.5%.
 10. The method of making the fertilizer composition of claim 9, wherein the NAPAOL comprises dimethyl sulfoxide.
 11. The method of making the fertilizer composition of claim 1, wherein the modified urea is selected from the group consisting of: i)

wherein R₄₃ and R₄₄, R₄₅ and R₄₆ are one or more members independently selected from the group consisting of: H and —CH₂—NH—CO—NH₂ with the proviso that at least one of R₄₃ and R₄₄, R₄₅ and R₄₆ is —CH₂—NH—CO—NH₂, ii)

wherein R₄₇, R₄₈, R₄₉ R₅₀, R₅₁ and R₅₂ are one or more members independently selected from the group consisting of: H, and —CH₂—NH—CO—NH₂, wherein the method of making the composition comprises reacting molten urea with BPONI in a temperature range of 80-140° C., and wherein each modified urea i)-ii) has at least one —CH₂—NH—CO—NH₂ functionality.
 12. The method of making the fertilizer composition of claim 9, wherein the fertilizer composition further comprises one or more nitrogen sources selected from the group consisting of i) ammonia, ii) ammonium hydroxide, iii) urea formaldehyde reaction products, iv) urea, formaldehyde and ammonia reaction products, v) ammonium nitrate, vi) ammonium sulfite, vii) manure viii) monoammonium phosphate ix) diammonium phosphate, and x) compost.
 13. The method of making the fertilizer composition of claim 9, wherein the fertilizer composition further comprises a) unreacted dicyandiamide b) an aprotic NOSDS, c) a protic NOSDS, and d) one or more members selected from the group consisting of: a. a colorant; b. scents or masking agents; c. nonionic, anionic, cationic, zwitterionic, and/or amphoteric surfactants; and d. buffering agents; e. catalyst(s).
 14. The method of making the fertilizer composition of claim 13 wherein the aprotic NOSDS comprises one or more solvents selected from the group consisting of: i) dimethyl sulfoxide, i. ii) dialkyl, diaryl, or alkylaryl sulfoxide(s) having the formula: R₉S(O)_(x)R₁₀, wherein R₉ and R₁₀ are each independently a C₁₋₆ alkylene group, an aryl group, or C₁₋₃alkylenearyl group or R₉ and R₁₀ together with the sulfur to which they are attached form a 4 to 8 membered ring wherein R₉ and R₁₀ together are a C₁₋₆ alkylene group which optionally contains one or more atoms selected from the group consisting of O, S, Se, Te, N, and P in the ring and x is 1 or 2, and iii) one or more alkylene carbonates selected from the group consisting of ethylene carbonate, propylene carbonate and butylene carbonate, iv) one or more alkyl pyrrolidones selected from the group consisting of 1-Methyl-2-pyrrolidone and butyl pyrrolidone, v) one or more organo phosphorous liquids selected from the group consisting of hexamethylphosphoramide and one or more trialkylphosphates selected from the group represented by the formula:

wherein: R₂₂ is alkyl radical —C₁H₃ to —C₆H₁₃ R₂₃ is alkyl radical —C₁H₃ to —C₆H₁₃ R₂₄ is alkyl radical —C₁H₃ to —C₆H₁₃ vi) 1,2-dimethyloxyethane, vii) 2-methoxyethyl ether and viii) cyclohexylpyrrolidone.
 15. The method of making the fertilizer composition of claim 13, wherein the protic NOSDS comprises one or more solvents selected from the group consisting of i) an alcohol selected from the group consisting of C₁₋₁₀ alkanols, ii) one or more polyols selected from the group consisting of trimethylol propane, trimethylol ethane, pentaerythritol, sorbitol, sorbitan, glucose, fructose, galactose, and glycerin, iii) poly(C₁₋₁₀alkylene) glycols, iv) one or more alkylene glycols selected from the group consisting of ethylene glycol, 1,3 propylene glycol, 1,2 propylene glycol, and butylene glycol, v) isopropylidene glycerol vi) one or more alkylene glycol alkyl ethers represented by the structure:

where R¹ is: CH₃, C₂H₅, C₃H₇ or C₄H₉

where R² is: H or where R³ is: H or CH₃ where R⁴ is H and/or CH₃ and f is an integer between 1 and 15 vii) one or more alkyl lactates selected from the group consisting of ethyl, propyl and butyl lactate, viii) one or more alkanolamines represented by the structure:

where R⁵ is: C₂H₄OR⁸ or C₃H₆OH where R⁶ is: H, C₂H₄OR⁸ or C₃H₆OH where R⁷ is: H, C₂H₄OR⁸ or C₃H₆OH where R⁸ is: (C₂H₄O)_(g)H and g is an integer between 1-10, and ix) glycerol carbonate.
 16. The method of making the fertilizer composition of claim 9, wherein the urea is chemically modified in its molten state by the addition of BPONI wherein NAPAOL is a reaction medium for modification of the urea, wherein said fertilizer composition is further modified by one or more processes selected from the group consisting of a) an urea rotating drum granulation, b) an urea fluidized bed granulation, and c) an urea prilling tower process.
 17. The method of making the fertilizer composition of claim 16, wherein the urea rotating drum granulation process is comprised of one or more steps selected from the group consisting of a. a step wherein the BPONI is charged and mixed into the molten urea, b. a step wherein the urea and the modified urea is pumped to the spraying nozzles, c. a step wherein the fertilizer composition is sprayed onto a bed of urea particles inside a rotating drum to coat the urea particles with a thin layer of the fertilizer composition, d. a step wherein forced air is passed over the bed of urea particles removing heat and allowing the thin layer of the fertilizer composition to solidify, e. a step wherein the urea rotating drum granulation process is repeated.
 18. The method of making the fertilizer composition of claim 16, wherein the urea fluidized bed granulation process is comprised of one or more steps selected from the group consisting of: a. a step wherein the BPONI is charged and mixed into the molten urea forming modified urea, b. a step wherein the fertilizer composition is pumped to the spraying nozzles, c. a step wherein the fertilizer composition is sprayed onto a bed of urea particles inside a fluid bed granulator thereby coating the urea particles with a thin layer of the fertilizer composition, d. a step wherein rotating or rolling of the urea particles is accomplished by use of large volumes of air blown up through the bed of urea particles thereby removing heat and allowing the thin layer of the fertilizer composition to solidify, e. the urea fluidized bed granulation process is repeated.
 19. The method of making the fertilizer composition of claim 16, wherein the urea prilling process is comprised of one or more steps selected from the group consisting of a. a step wherein the BPONI is charged and mixed into the molten urea forming modified urea, b. a step wherein the fertilizer composition is pumped to shower generating heads at the top of a prilling tower, c. a step wherein droplets of the the fertilizer composition form as they pass through the shower generating heads into the prilling tower, d. a step wherein counter current air flows up the pilling tower cooling the droplets below a freezing point and thus, form prills.
 20. The method of making the fertilizer composition of claim 16, wherein the fertilizer composition further comprises unreacted DCD. 